INT65226

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Context Info
Confidence 0.36
First Reported 1996
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.60
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (NARG2)
Anatomy Link Frequency
brain 2
NARG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 5 100.00 Very High Very High Very High
Endogenous opioid 1 100.00 Very High Very High Very High
Hyperalgesia 1 100.00 Very High Very High Very High
antagonist 2 99.64 Very High Very High Very High
Preemptive analgesia 5 96.84 Very High Very High Very High
Perioperative pain 2 92.00 High High
Pain management 1 89.44 High High
Pain 5 89.36 High High
isoflurane 10 86.60 High High
analgesia 1 82.96 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 2 100.00 Very High Very High Very High
Post Operative Pain 2 92.00 High High
Pain 6 89.44 High High
Apoptosis 7 82.04 Quite High
Alzheimer's Dementia 2 78.28 Quite High
Disease 2 72.68 Quite High
Neurodegenerative Disease 1 71.44 Quite High
Nociception 1 65.84 Quite High
Injury 1 50.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Future studies are needed to test effective blockade of afferent input while controlling perception, hyperalgesia, and NMDA receptor activity.
Regulation (controlling) of NMDA receptor associated with hyperalgesia and nmda receptor
1) Confidence 0.36 Published 2003 Journal Clin Podiatr Med Surg Section Abstract Doc Link 12776979 Disease Relevance 0.90 Pain Relevance 1.34
It is as yet unknown to which receptor system ORG 2766 binds; the analog lacks affinity for the known melanocortin (MC) receptors in brain, yet ORG 2766 is able to modulate the activity of endogenous opioids and the NMDA-receptor.
Regulation (modulate) of NMDA-receptor in brain associated with endogenous opioid
2) Confidence 0.15 Published 1996 Journal Behav. Brain Res. Section Abstract Doc Link 8851911 Disease Relevance 0.05 Pain Relevance 0.13
Finally, we examined the effects of the NMDA receptor partial antagonist, memantine, in H4-APP cells and brain tissue of naive mice.
Spec (examined) Regulation (effects) of NMDA receptor in brain associated with antagonist and nmda receptor
3) Confidence 0.04 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18434534 Disease Relevance 0.65 Pain Relevance 0.53

General Comments

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