INT65246

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Context Info
Confidence 0.50
First Reported 1996
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 36
Total Number 37
Disease Relevance 25.65
Pain Relevance 7.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) Golgi apparatus (Nos3) cytoplasm (Nos3)
signal transduction (Nos3) oxidoreductase activity (Nos3) nucleolus (Nos3)
Anatomy Link Frequency
blood 3
neuronal 2
Bar 1
retinas 1
platelets 1
Nos3 (Mus musculus)
Pain Link Frequency Relevance Heat
Hyperalgesia 20 99.84 Very High Very High Very High
cINOD 13 99.84 Very High Very High Very High
Inflammation 457 99.12 Very High Very High Very High
Thermal hyperalgesia 46 98.76 Very High Very High Very High
Neuronal nitric oxide synthase 1 98.40 Very High Very High Very High
tetrodotoxin 8 98.38 Very High Very High Very High
metalloproteinase 80 97.52 Very High Very High Very High
intrathecal 2 97.48 Very High Very High Very High
aspirin 15 96.20 Very High Very High Very High
Bioavailability 14 95.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 258 99.96 Very High Very High Very High
Diabetes Mellitus 852 99.88 Very High Very High Very High
Peritonitis 288 99.88 Very High Very High Very High
Hyperalgesia 80 99.84 Very High Very High Very High
Metabolic Syndrome 276 99.64 Very High Very High Very High
Insulin Resistance 256 99.60 Very High Very High Very High
Atherosclerosis 237 99.48 Very High Very High Very High
Stress 395 99.36 Very High Very High Very High
Prediabetic State 180 99.32 Very High Very High Very High
Hypertension 204 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because nNOS is constitutively expressed in eNOS mutants, these findings coupled with the TTX results suggest that an nNOS-dependent mechanism may compensate for the chronic loss of eNOS activity after targeted gene disruption.
Negative_regulation (loss) of eNOS associated with tetrodotoxin
1) Confidence 0.50 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8853353 Disease Relevance 0.13 Pain Relevance 0.41
Mice lacking eNOS (eNOS KO) and their wild-type littermates (eNOS WT) were generated as described previously [17] and obtained from the Jackson Laboratory (Bar Harbor, ME, USA).
Negative_regulation (lacking) of eNOS in Bar associated with targeted disruption
2) Confidence 0.48 Published 2010 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2796899 Disease Relevance 0.78 Pain Relevance 0
METHODS: C57BL6/J mice deficient in eNOS (eNOS KO) or iNOS (iNOS KO) and wild-type mice (WT) were treated with 300 mg/kg APAP.
Negative_regulation (deficient) of eNOS
3) Confidence 0.48 Published 2006 Journal Acad Emerg Med Section Body Doc Link 16551773 Disease Relevance 0.10 Pain Relevance 0
Accumulating evidence, including findings of elevation of arterial blood pressure in mice lacking the endothelial nitric oxide synthase (eNOS) gene, strongly suggests that alteration in NO metabolism is implicated in hypertension.
Negative_regulation (lacking) of eNOS in blood associated with hypertension
4) Confidence 0.43 Published 1998 Journal Hypertension Section Abstract Doc Link 9674630 Disease Relevance 0.69 Pain Relevance 0.07
Accumulating evidence, including findings of elevation of arterial blood pressure in mice lacking the endothelial nitric oxide synthase (eNOS) gene, strongly suggests that alteration in NO metabolism is implicated in hypertension.
Negative_regulation (lacking) of endothelial nitric oxide synthase in blood associated with hypertension
5) Confidence 0.43 Published 1998 Journal Hypertension Section Abstract Doc Link 9674630 Disease Relevance 0.69 Pain Relevance 0.07
The selective inhibitor of eNOS L-NIO, but not the inhibitors of nNOS (N-omega-propyl-L-arginine) or iNOS (1400w), blocked the effect of loperamide on osteosarcoma-induced hyperalgesia and also the endogenous opioid peripheral hypoalgesia that appears during the initial stages of the development of this osteosarcoma.
Negative_regulation (inhibitor) of eNOS associated with hyperalgesia, endogenous opioid, hypoalgesia and osteogenic sarcomas
6) Confidence 0.40 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17543351 Disease Relevance 0.95 Pain Relevance 0.95
Compared to the anti-hyperalgesic effects of 7-NINA and AG, we found that L-NIO, a selective eNOS inhibitor, had no significant effect on thermal hyperalgesia.
Negative_regulation (inhibitor) of eNOS associated with hyperalgesia and thermal hyperalgesia
7) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 1.19 Pain Relevance 0.99
The down regulation of eNOS by NSAIDs, on the other hand, is in line with the suppression of eNOS expression by high-dose aspirin or meloxicam, in retinas of diabetic rats [36].
Negative_regulation (regulation) of eNOS in retinas associated with aspirin, diabetes mellitus and cinod
8) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949722 Disease Relevance 0.59 Pain Relevance 0.85
We have shown previously that mice lacking eNOS are protected against functional and structural modifications in a 6-day model of peritonitis [15].
Negative_regulation (lacking) of eNOS associated with peritonitis
9) Confidence 0.35 Published 2010 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2796899 Disease Relevance 0.71 Pain Relevance 0.07
These data give new insights in the differential roles of NOS isoforms in the peritoneal membrane and suggest that selective eNOS inhibition may improve peritoneal transport during acute peritonitis, whereas non-specific NOS inhibitors may impair host-defence mechanisms [49,50].



Negative_regulation (inhibition) of eNOS associated with peritonitis
10) Confidence 0.35 Published 2010 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2796899 Disease Relevance 0.94 Pain Relevance 0.17
Mice lacking eNOS, which have a higher mean arterial blood pressure (MAP) at baseline [15,17], showed a trend for higher MAP during acute peritonitis (Table 1).
Negative_regulation (lacking) of eNOS in blood associated with peritonitis
11) Confidence 0.35 Published 2010 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2796899 Disease Relevance 0.57 Pain Relevance 0.08
These data demonstrate specific roles for NOS isoforms in the peritoneal membrane and suggest that selective eNOS inhibition may improve peritoneal transport during acute peritonitis.



Negative_regulation (inhibition) of eNOS associated with peritonitis
12) Confidence 0.35 Published 2010 Journal Nephrology Dialysis Transplantation Section Abstract Doc Link PMC2796899 Disease Relevance 0.36 Pain Relevance 0.05
The transport alterations induced by peritonitis were reversed in eNOS KO mice, whereas the inflammatory changes were more severe in iNOS KO mice.
Negative_regulation (reversed) of eNOS associated with targeted disruption, inflammation and peritonitis
13) Confidence 0.35 Published 2010 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2796899 Disease Relevance 1.06 Pain Relevance 0.18
METHODS: C57BL6/J mice deficient in eNOS (eNOS KO) or iNOS (iNOS KO) and wild-type mice (WT) were treated with 300 mg/kg APAP.
Negative_regulation (deficient) of eNOS
14) Confidence 0.35 Published 2006 Journal Acad Emerg Med Section Body Doc Link 16551773 Disease Relevance 0.10 Pain Relevance 0
Several risk factors for coronary artery disesase (CAD) such as smoking, elevated homocysteine, free fatty acids, hypertension, insulin resistance, and diabetes also depress eNOS [2,6,8].
Negative_regulation (depress) of eNOS in coronary artery associated with nicotine addiction, coronary artery disease, diabetes mellitus, hypertension and insulin resistance
15) Confidence 0.32 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2636751 Disease Relevance 1.53 Pain Relevance 0.21
Alanine aminotransferase levels were significantly lower in eNOS KO and iNOS KO than in treated WT animals.
Negative_regulation (lower) of eNOS
16) Confidence 0.30 Published 2006 Journal Acad Emerg Med Section Body Doc Link 16551773 Disease Relevance 0.08 Pain Relevance 0
In addition, it has been reported that other derivatives of C60 fullerenes (called C3- or D3-tris-malonyl-C60-fullerene) inhibited the activity of eNOS and C3-tris-malonyl C60 fullerenes, which had the largest hydrophobic surface area, inhibited eNOS the most [35].
Negative_regulation (inhibited) of eNOS
17) Confidence 0.29 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2672923 Disease Relevance 0.07 Pain Relevance 0
Interestingly, compared to the unchanged hyperalgesia in the eNOS inhibitor L-NIO-treated mice after CFA, thermal hyperalgesia was significantly attenuated by the iNOS inhibitor AG, although AG also simultaneously reduced TNF, IL-1?
Negative_regulation (inhibitor) of eNOS associated with hyperalgesia and thermal hyperalgesia
18) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 1.33 Pain Relevance 0.73
Molecular changes were examined by assessing eNOS, iNOS, HO-1 and COX-2 expression in whole-kidney lysates by Western immunoblotting, and cellular colocalization of these enzymes was determined using immunofluorescence microscopy.
Spec (examined) Negative_regulation (assessing) of eNOS in kidney
19) Confidence 0.28 Published 2007 Journal Nephron Exp. Nephrol. Section Body Doc Link 17220637 Disease Relevance 0 Pain Relevance 0
Experimental studies in vitro have revealed that NO from eNOS constitutes an antiatherogenic molecule and that a deficiency of eNOS accelerates atherosclerotic lesion formation in eNOS knockout mice (Kawashima and Yokoyama 2004).
Negative_regulation (deficiency) of eNOS associated with targeted disruption and atherosclerosis
20) Confidence 0.25 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.01 Pain Relevance 0.31

General Comments

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