INT65258

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Context Info
Confidence 0.55
First Reported 1996
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 8.26
Pain Relevance 2.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Col7a1) cell adhesion (Col7a1) proteinaceous extracellular matrix (Col7a1)
Anatomy Link Frequency
lungs 11
fibroblasts 8
stroma 2
podocytes 2
skin 1
Col7a1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 80 99.80 Very High Very High Very High
fibrosis 259 99.56 Very High Very High Very High
Inflammation 340 99.00 Very High Very High Very High
Pain 1 98.60 Very High Very High Very High
cINOD 5 98.20 Very High Very High Very High
metalloproteinase 52 94.96 High High
medulla 1 85.60 High High
ketamine 3 85.04 High High
anesthesia 15 83.28 Quite High
Arthritis 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Cancer 24 100.00 Very High Very High Very High
Necrosis 6 100.00 Very High Very High Very High
Adenoma 2 99.84 Very High Very High Very High
Fibrosis 204 99.56 Very High Very High Very High
INFLAMMATION 372 99.00 Very High Very High Very High
Stress 41 98.86 Very High Very High Very High
Arthralgia 1 98.60 Very High Very High Very High
Disease 54 97.00 Very High Very High Very High
Aging 65 95.98 Very High Very High Very High
Oral Submucous Fibrosis 4 93.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, elevated levels of IGF-1 appear to affect collagen both quantitatively and qualitatively, primarily through their effects on gene expression of collagen and of those enzymes responsible for posttranslational modifications of collagen.
Regulation (effects) of Gene_expression (expression) of collagen
1) Confidence 0.55 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8853393 Disease Relevance 0 Pain Relevance 0.11
We have not studied the COL1A1 gene in our population, but the increased Smax, which indicates altered collagen properties in CI-patients, could reflect the findings by Warren et al.
Regulation (altered) of Gene_expression (properties) of collagen
2) Confidence 0.36 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2927597 Disease Relevance 0.09 Pain Relevance 0
METHODS: Primary mice oral fibroblasts were cultured, the effects of borneol on fibroblasts proliferation, cytotoxicity, collagen production, matrix metalloproteinases-2,9 (MMP-2,9) activities and tissue inhibitors of metalloproteinase 1 (TIMP-1) production were tested by methyl thiazolyl tetrazolium assay, lactic dehydrogenase activity assay, chloramine T method, gelatin zymography and enzyme-linked immunosorbent assay, respectively.
Regulation (effects) of Gene_expression (production) of collagen in fibroblasts
3) Confidence 0.15 Published 2009 Journal J. Oral Pathol. Med. Section Body Doc Link 19267840 Disease Relevance 0.09 Pain Relevance 0
CONCLUSIONS: This study indicates that borneol has anti-fibrosis activity and the mechanism may partly be relevant to its inhibiting effects on fibroblasts mitosis, collagen and TIMP-1 production.
Regulation (effects) of Gene_expression (production) of collagen in fibroblasts
4) Confidence 0.15 Published 2009 Journal J. Oral Pathol. Med. Section Body Doc Link 19267840 Disease Relevance 0.06 Pain Relevance 0
It is possible that the hormonal imbalance related to the aging process, together with the potential loss in mechanical tension of the smooth-muscle cells in the aged prostate stroma, as observed by classic histology and transmission electron microscopy, may well affect collagen synthesis and organization.
Spec (may) Regulation (affect) of Gene_expression (synthesis) of collagen in stroma associated with aging
5) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0.58 Pain Relevance 0.04
Effect of PDE4 inhibition on lung collagen content and remodeling markers
Regulation (lung) of Gene_expression (content) of collagen in lung
6) Confidence 0.07 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 0.39 Pain Relevance 0.20
Effect of PDE4 inhibition on lung collagen content and remodeling markers
Regulation (Effect) of Gene_expression (content) of collagen in lung
7) Confidence 0.07 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 0.40 Pain Relevance 0.20
The effects of taurine (T) and niacin (N) on bleomycin (BL)-induced increased production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1alpha, IL-6, and transforming growth factor-beta (TGF-beta) levels in the bronchoalveolar lavage fluid (BALF), and increased collagen content and nuclear factor-kappaB (NF-kappaB) activation in the lungs were investigated in mice.
Spec (investigated) Regulation (effects) of Gene_expression (content) of collagen in lungs associated with necrosis and cancer
8) Confidence 0.06 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10734156 Disease Relevance 0.35 Pain Relevance 0.16
Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ mice.
Regulation (alters) of Gene_expression (expression) of collagen associated with adenoma
9) Confidence 0.06 Published 2008 Journal Carcinogenesis Section Title Doc Link 18499699 Disease Relevance 0.81 Pain Relevance 0.20
The purpose of this study was to examine whether inhibition of SPARC can regulate collagen expression in vitro and in vivo, and subsequently attenuate fibrotic stimulation by bleomycin in mouse skin and lungs.


Regulation (regulate) of Gene_expression (expression) of collagen in lungs associated with fibrosis
10) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2888211 Disease Relevance 0.52 Pain Relevance 0.07
It has been suggested that as the LMX1B gene encodes a LIM homeodomain transcription factor, which contributes to transcriptional regulation of glomerular membrane collagen expression by podocytes, both renal and ocular malformations could result from the same alteration during embryogenesis.
Regulation (regulation) of Gene_expression (expression) of collagen in podocytes
11) Confidence 0.05 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2669506 Disease Relevance 0.92 Pain Relevance 0.03
But to further evaluate regarding collagen synthesis and remodeling, the mouse model itself has limitations.
Regulation (regarding) of Gene_expression (synthesis) of collagen
12) Confidence 0.04 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844601 Disease Relevance 0.71 Pain Relevance 0.25
Lung collagen assay
Regulation (Lung) of Gene_expression (assay) of collagen in Lung
13) Confidence 0.04 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0 Pain Relevance 0.11
The percentage of positive staining for collagen, ?
Regulation (percentage) of Gene_expression (staining) of collagen
14) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 0.09 Pain Relevance 0.20
MMP-9 levels were highly correlated with neutrophil infiltration, while MMP-2 is known to be produced mainly by epithelial [27] and mesenchymal cells, such as fibroblasts, which are involved in collagen production and deposition [9,25].
Regulation (involved) of Gene_expression (production) of collagen in fibroblasts
15) Confidence 0.03 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.27 Pain Relevance 0.11
The purpose of this study was to examine whether inhibition of SPARC can regulate collagen expression in vitro and in vivo, and subsequently attenuate fibrotic stimulation by bleomycin in mouse skin and lungs.


Regulation (regulate) of in skin Gene_expression (expression) of collagen in lungs associated with fibrosis
16) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2888211 Disease Relevance 0.52 Pain Relevance 0.07
These cytokines not only regulate fibroblast function and collagen synthesis, but also recruit other inflammatory cells and contribute to the pathogenesis of both acute and late RT damage [38].
Regulation (regulate) of Gene_expression (synthesis) of collagen in fibroblast associated with inflammation and cytokine
17) Confidence 0.01 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1177930 Disease Relevance 1.15 Pain Relevance 0.36
Previously, we proved that KE up-regulated the synthesis of collagen in false aged model rats.
Regulation (regulated) of Gene_expression (synthesis) of collagen
18) Confidence 0.01 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18520054 Disease Relevance 0.79 Pain Relevance 0.16
Other forms of oxidative stress derived from tert-butyl hydroperoxide and iron can also modify collagen synthesis, by a mechanism presumably involving redox sensor/receptor.
Regulation (modify) of Gene_expression (synthesis) of collagen associated with stress
19) Confidence 0.00 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.50 Pain Relevance 0.29

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