INT65259

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Context Info
Confidence 0.66
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.80
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Lox) extracellular region (Lox) proteinaceous extracellular matrix (Lox)
nucleus (Lox)
Anatomy Link Frequency
endothelium 2
granulation 2
Lox (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 41 99.00 Very High Very High Very High
Inflammation 37 97.52 Very High Very High Very High
anesthesia 7 90.84 High High
halothane 2 90.40 High High
metalloproteinase 3 90.00 High High
alcohol 2 86.36 High High
aspirin 10 74.96 Quite High
imagery 46 55.28 Quite High
Bile 1 52.76 Quite High
ketamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 66 99.96 Very High Very High Very High
Cancer 186 99.04 Very High Very High Very High
Cystic Fibrosis 35 99.00 Very High Very High Very High
Metastasis 186 98.24 Very High Very High Very High
INFLAMMATION 30 97.52 Very High Very High Very High
Chronic Renal Failure 10 96.76 Very High Very High Very High
Adhesions 21 86.72 High High
Osteolysis 12 53.12 Quite High
Albuminuria 10 50.00 Quite Low
Pseudomonas Infection 3 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In blood vessels LOX is expressed both the endothelium and the vascular smooth muscle cells [14], [45], [46], [47]; LOX expression is also upregulated in invasive breast cancer cells [22], [23].
Positive_regulation (upregulated) of Gene_expression (expression) of LOX in endothelium associated with breast cancer
1) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680032 Disease Relevance 0.64 Pain Relevance 0
Both up- and down-regulation of LOX has been observed in different cancer cell lines and primary tumors (reviewed in [21]), however, in breast cancer, elevated LOX expression has been positively-correlated with invasiveness, as well as with reduced metastasis-free and overall survival [16], [22], [23], [24], [25].
Positive_regulation (elevated) of Gene_expression (expression) of LOX associated with cancer, breast cancer and metastasis
2) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680032 Disease Relevance 1.13 Pain Relevance 0.04
In addition, increased LOX expression has been correlated with decreases in both metastases-free, and overall survival in breast cancer patients.
Positive_regulation (increased) of Gene_expression (expression) of LOX associated with breast cancer and metastasis
3) Confidence 0.44 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2680032 Disease Relevance 0.61 Pain Relevance 0.03
Indeed, the expression level of this LOX has been shown to increase in bronchial tissues of CF patients [27].
Positive_regulation (increase) of Gene_expression (expression) of LOX associated with fibrosis
4) Confidence 0.29 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.23 Pain Relevance 0.21
To further elucidate the lack of beneficial effects of sEH inhibition on the progression of chronic renal failure, we investigated the pro-inflammatory lipoxygenase system. 5/6-Nx had no significant effect on the renal expression of 5-Lox and 12-Lox, whereas a trend towards increased expression of 15-Lox was observed.
Positive_regulation (increased) of Gene_expression (expression) of Lox associated with chronic renal failure and inflammation
5) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2915917 Disease Relevance 0.19 Pain Relevance 0.08
Expression of types I and III collagen, lysyl oxidase, and lysyl hydroxylase was increased in all tissues analyzed.
Positive_regulation (increased) of Gene_expression (Expression) of lysyl oxidase
6) Confidence 0.17 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8853393 Disease Relevance 0 Pain Relevance 0.18
These results suggest that 1) elevated circulating IGF-1 may increase collagen deposition both in normal tissue as well as in granulation tissue by increasing collagen gene expression, 2) IGF-1 may increase collagen cross-linking by stimulating expression of lysyl oxidase, and 3) the preferential increase in dihydroxylated cross-links observed in high-growth mice may be due to the stimulation of lysyl hydroxylase expression by IGF-1.
Positive_regulation (stimulating) of Gene_expression (expression) of lysyl oxidase in granulation
7) Confidence 0.17 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8853393 Disease Relevance 0 Pain Relevance 0.14

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