INT65260

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Context Info
Confidence 0.69
First Reported 1996
Last Reported 2010
Negated 9
Speculated 2
Reported most in Body
Documents 95
Total Number 97
Disease Relevance 61.73
Pain Relevance 18.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Col7a1) cell adhesion (Col7a1) proteinaceous extracellular matrix (Col7a1)
Anatomy Link Frequency
lung 11
plasma 5
Liver 4
plaque 3
extracellular matrix 3
Col7a1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 913 99.84 Very High Very High Very High
Paracetamol 36 99.84 Very High Very High Very High
Inflammatory response 171 99.82 Very High Very High Very High
Inflammation 1544 99.78 Very High Very High Very High
cytokine 735 99.76 Very High Very High Very High
Arthritis 583 99.64 Very High Very High Very High
Morphine 8 99.62 Very High Very High Very High
aspirin 208 99.58 Very High Very High Very High
Central nervous system 15 99.48 Very High Very High Very High
Deafferentation 1 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Systemic Sclerosis 235 100.00 Very High Very High Very High
Immunization 69 100.00 Very High Very High Very High
Hyperplasia 44 100.00 Very High Very High Very High
Urological Neuroanatomy 6 100.00 Very High Very High Very High
Experimental Arthritis 3 100.00 Very High Very High Very High
Fibrosis 697 99.84 Very High Very High Very High
Cancer 187 99.84 Very High Very High Very High
Osteoporosis 19 99.84 Very High Very High Very High
INFLAMMATION 1655 99.78 Very High Very High Very High
Eosinophilia 26 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At 8 weeks, the mandibular condyle was structurally developed with an increase of collagen fibrils in the synovium; a fully mature condyle was observed at 6 months of age.
Positive_regulation (increase) of collagen in synovium
1) Confidence 0.69 Published 2001 Journal Arch. Histol. Cytol. Section Abstract Doc Link 11310505 Disease Relevance 0.17 Pain Relevance 0.22
Collagen, expressed per weight of tissue, was significantly increased in all tissues from high-growth mice, as was collagen cross-linking, expressed as moles of cross-link per mole of collagen.
Positive_regulation (increased) of Collagen
2) Confidence 0.62 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8853393 Disease Relevance 0 Pain Relevance 0.18
Rate and extent of accumulation of collagen in granulation tissue were measured in polyvinyl alcohol sponges implanted subcutaneously; collagen accumulation was significantly greater in the high-growth mice.
Positive_regulation (accumulation) of collagen in granulation associated with alcohol
3) Confidence 0.62 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8853393 Disease Relevance 0 Pain Relevance 0.17
Rate and extent of accumulation of collagen in granulation tissue were measured in polyvinyl alcohol sponges implanted subcutaneously; collagen accumulation was significantly greater in the high-growth mice.
Positive_regulation (accumulation) of collagen in granulation associated with alcohol
4) Confidence 0.62 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8853393 Disease Relevance 0 Pain Relevance 0.17
An explanation for the increased collagen tensile strength (Smax ) and stiffness (S'max) in the CI group is not obvious.
Positive_regulation (increased) of collagen
5) Confidence 0.56 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2927597 Disease Relevance 0.15 Pain Relevance 0
We suggest that He-Ne laser promotes collagen formation and restores the baseline cellularity after pharmacological inhibition, indicating new perspectives for laser therapy aiming to increase the healing process when anti-inflammatory drugs are used.
Positive_regulation (promotes) of collagen associated with inflammation and cinod
6) Confidence 0.50 Published 2007 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 17581688 Disease Relevance 0.61 Pain Relevance 0.37
Collagen assays also demonstrated that tissue concentrations of collagen were significantly increased in the wound tissue of morphine-treated animals on day 2 of drug treatment.
Positive_regulation (increased) of collagen
7) Confidence 0.46 Published 2010 Journal J Anesth Section Body Doc Link 20127122 Disease Relevance 0.05 Pain Relevance 0
Previous studies have shown that morphine enhances accumulation of collagen in cultured fibroblasts.
Positive_regulation (accumulation) of collagen in fibroblasts associated with morphine
8) Confidence 0.46 Published 2010 Journal J Anesth Section Abstract Doc Link 20127122 Disease Relevance 0.36 Pain Relevance 0.55
However, when values were adjusted for age and parity, the maximum stiffness normalized for collagen was found to be increased in the CI group (p = 0.008; Table 3).
Positive_regulation (increased) of collagen
9) Confidence 0.38 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2927597 Disease Relevance 0 Pain Relevance 0
In addition, during carotid endarterectomy, preoperative platelet aggregation induced with collagen was significantly higher in patients with more microemboli on intraoperative transcranial doppler monitoring [9].
Positive_regulation (induced) of collagen in platelet
10) Confidence 0.36 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872863 Disease Relevance 0.55 Pain Relevance 0.23
This study shows that high response to collagen on preoperative WBA is associated with increased perioperative myocardial injury in the patients undergoing off-pump CABG even if they take aspirin.
Positive_regulation (response) of collagen associated with aspirin and injury
11) Confidence 0.36 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872863 Disease Relevance 0.40 Pain Relevance 0.08
We investigated whether plasma-mediated collagen coating possesses the ability to enhance neovascularization in the vicinity of silicone implants.
Spec (whether) Positive_regulation (mediated) of collagen in plasma
12) Confidence 0.28 Published 2010 Journal Eplasty Section Abstract Doc Link PMC2948451 Disease Relevance 0 Pain Relevance 0
Previous in vitro cell experiments revealed that cell adhesion and cell viability of murine fibroblasts is significantly enhanced on plasma-activated and collagen-coated silicone implants.26 Besides, it was observed that the surface modification by gas plasma influenced the progress of new vessel formation and promoted vascular infiltration in polymer scaffolds.21
Positive_regulation (enhanced) of collagen in plasma associated with adhesions
13) Confidence 0.28 Published 2010 Journal Eplasty Section Body Doc Link PMC2948451 Disease Relevance 0.23 Pain Relevance 0
Whether the plasma-mediated collagen coating will permit prolonged inhibition of an avascular capsule formation is unknown.
Spec (Whether) Positive_regulation (mediated) of collagen in capsule
14) Confidence 0.28 Published 2010 Journal Eplasty Section Body Doc Link PMC2948451 Disease Relevance 0.29 Pain Relevance 0.12
The results presented indicate that plasma-mediated collagen coating may be a promising strategy to increase vascularity around implants thus enhancing the biocompatibility and the versatility of silicone implant material.
Positive_regulation (mediated) of collagen in plasma
15) Confidence 0.28 Published 2010 Journal Eplasty Section Body Doc Link PMC2948451 Disease Relevance 0.53 Pain Relevance 0.15
Increased collagen adsorption and improved collagen adhesion to plasma-treated implant surfaces was later shown by Gölander et al,29 who proved that the extent of surface-free energy is a decisive factor in terms of the protein-binding capacity of an implant surface.
Positive_regulation (Increased) of collagen in plasma associated with adhesions
16) Confidence 0.28 Published 2010 Journal Eplasty Section Body Doc Link PMC2948451 Disease Relevance 0.28 Pain Relevance 0
These results indicate that plasma-mediated collagen coating might be a promising technology in order to improve the biocompatibility and versatility of silicone implants.



Positive_regulation (mediated) of collagen in plasma
17) Confidence 0.28 Published 2010 Journal Eplasty Section Abstract Doc Link PMC2948451 Disease Relevance 0 Pain Relevance 0
There was a significant difference in the distribution of collagen fibril diameters between wild-type and mutant Achilles tendons with a relative increase in the numbers of thicker collagen fibrils in the mutant samples at both 3 and 9 weeks of age (Fig. 4A and B; P < 0.05 and P < 0.005, respectively, by Mann–Whitney U test, n > 3).
Positive_regulation (increase) of collagen in tendons
18) Confidence 0.22 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.15 Pain Relevance 0
In agreement with the immunofluorescence analysis for Collagen Type I, we found that despite the lower levels of procollagen I alpha-1 mRNA in the aged animals, they also exhibited a dramatic increase in collagen fibers in the stroma as determined by TEM (compared Figure 6Ci and 6Di, brace).
Positive_regulation (increase) of collagen in stroma
19) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0.08 Pain Relevance 0.03
In a study on early molecular events in SSc, COL7A1 and COL18A1 were found as putative biomarkers for early onset of SSc, both upregulated in fibroblasts from uninvolved skin lesions of SSc patients compared with controls [62].
Positive_regulation (upregulated) of COL7A1 in skin associated with systemic sclerosis
20) Confidence 0.17 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.11 Pain Relevance 0.22

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