INT65261

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Context Info
Confidence 0.55
First Reported 1996
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 18
Total Number 21
Disease Relevance 8.70
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Col7a1) cell adhesion (Col7a1) proteinaceous extracellular matrix (Col7a1)
Anatomy Link Frequency
tendons 3
fat 1
dermis 1
platelets 1
cornea 1
Col7a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 159 98.76 Very High Very High Very High
aspirin 103 96.04 Very High Very High Very High
fibrosis 26 93.60 High High
metalloproteinase 9 93.24 High High
Pain 30 88.12 High High
anesthesia 21 85.36 High High
alcohol 5 76.28 Quite High
imagery 16 63.60 Quite High
Osteoarthritis 18 57.00 Quite High
halothane 7 54.52 Quite High
Disease Link Frequency Relevance Heat
Benign Prostatic Hypertrophy 21 98.96 Very High Very High Very High
INFLAMMATION 173 98.76 Very High Very High Very High
Adenocarcinoma 3 98.64 Very High Very High Very High
Osteogenesis Imperfecta 336 98.32 Very High Very High Very High
Sprains And Strains 68 97.92 Very High Very High Very High
Obesity 15 97.90 Very High Very High Very High
Rupture 9 97.62 Very High Very High Very High
Cancer 33 97.60 Very High Very High Very High
Cicatrix 75 96.40 Very High Very High Very High
Stress 132 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, elevated levels of IGF-1 appear to affect collagen both quantitatively and qualitatively, primarily through their effects on gene expression of collagen and of those enzymes responsible for posttranslational modifications of collagen.
Regulation (affect) of collagen
1) Confidence 0.55 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8853393 Disease Relevance 0 Pain Relevance 0.12
These biopsies showed the coagulation of small vessels in the fatty tissue, the rupture of adipocytes, the appearance of small channels produced by laser action, reorganization of the reticular dermis, and coagulation of collagen in the fat tissue.
Regulation (coagulation) of collagen in fat associated with rupture and obesity
2) Confidence 0.39 Published 2008 Journal Aesthetic Plast Surg Section Body Doc Link PMC2696609 Disease Relevance 0.56 Pain Relevance 0
The efficacy of collagen dermis membrane and fibrin on cultured epidermal graft using an athymic mouse model.
Regulation (efficacy) of collagen in dermis
3) Confidence 0.37 Published 1999 Journal Ann Plast Surg Section Title Doc Link 10560869 Disease Relevance 0.35 Pain Relevance 0.09
Mouse or human platelets in which GPVI has been pharmacologically blocked or immunodeleted are unresponsive to collagen [15].
Regulation (unresponsive) of collagen in platelets
4) Confidence 0.32 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872863 Disease Relevance 0.61 Pain Relevance 0.06
Furthermore, the distribution of collagen fibril diameters in the mutant tendons and ligaments was altered towards thicker collagen fibrils, and the tendons became more lax in cyclic strain tests.
Regulation (altered) of collagen in tendons associated with sprains and strains
5) Confidence 0.20 Published 2010 Journal Human Molecular Genetics Section Abstract Doc Link PMC2792148 Disease Relevance 1.44 Pain Relevance 0.03
The detrimental effect of COMP mutations on collagen fibrillogenesis has been previously demonstrated in vitro (51).
Regulation (effect) of collagen
6) Confidence 0.20 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.12 Pain Relevance 0
It has been proposed that the tendon biomechanical function depends on the precise collagen fibre alignment in the tissue (54).
Regulation (depends) of collagen in tendon
7) Confidence 0.20 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.36 Pain Relevance 0
To investigate in greater detail the structural alterations of the collagen network in the aged prostate, we performed scanning electron microscopy using prostates from young and old animals.
Spec (investigate) Regulation (alterations) of collagen
8) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0 Pain Relevance 0.03
It is therefore possible that this C-terminal COMP mutation (T585M), which is close to the potential collagen-binding site (15,17), has a detrimental effect on the ‘catalyst’ function of COMP that could alter collagen fibril diameter in the mutant tissue and ultimately its biomechanical properties.
Regulation (alter) of collagen
9) Confidence 0.12 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0 Pain Relevance 0
Furthermore, these drugs had no influence on the collagen content of advanced lesions (Figure 3A).
Neg (no) Regulation (influence) of collagen
10) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943480 Disease Relevance 0.05 Pain Relevance 0.36
In the human prostate, the collagen tissue network appears to be altered in prostate pathologies (BPH and adenocarcinomas) [34], resembling in part the morphological changes in the collagen matrix observed in the normally aging mouse prostate.
Spec (appears) Regulation (altered) of collagen associated with adenocarcinoma, aging and benign prostatic hypertrophy
11) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0.77 Pain Relevance 0
Pertinent to the regulation of collagen in the prostate, androgen deprivation induces marked morphological changes in rat prostatic smooth muscle cells [62], [63] reduces collagen synthesis, and induces a collagen fibrillar reorganization in the rat ventral prostate [64], [65], [66].
Regulation (regulation) of collagen in ventral
12) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0.92 Pain Relevance 0.15
Mutations in these essential cofactors cause alterations in the post-translational chain modification and collagen folding that are responsible for autosomal recessive lethal or severe OI: type VII,11–13 type VIII and type IX.7,14,15 An additional recessive form (possibly type X?)
Spec (possibly) Regulation (responsible) of collagen associated with osteogenesis imperfecta
13) Confidence 0.07 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2940745 Disease Relevance 0.53 Pain Relevance 0
0.04) compared to saline treated groups (Figure 3) There were no significant changes in collagen content of hearts in the arginine butyrate-treated hearts.
Neg (no) Regulation (changes) of collagen in hearts
14) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888587 Disease Relevance 0.41 Pain Relevance 0.17
The defect in collagen fibrillogenesis is also seen in the cornea of lmx1b-/- mutant mice, thus supporting the role of LMX1B in collagen regulation.
Regulation (regulation) of collagen in cornea
15) Confidence 0.05 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2669506 Disease Relevance 0.42 Pain Relevance 0
It was observed that the amount of collagen in the EGF-treated group was larger than the control group.
Regulation (larger) of collagen
16) Confidence 0.04 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2844601 Disease Relevance 0.87 Pain Relevance 0.08
In the case of qualitative collagen defects (ie, a structural alteration in the type I collagen molecule), mutations (typically glycine substitutions) in the collagen genes are associated with more severe or lethal phenotypes.
Regulation (alteration) of collagen
17) Confidence 0.04 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2940745 Disease Relevance 0.29 Pain Relevance 0
These authors hypothesized that TSP-2 might function as a collagen fibril-associated protein that participates in the regulation of collagen fibril diameter and fibrillogenesis.
Regulation (regulation) of collagen
18) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575610 Disease Relevance 0.33 Pain Relevance 0.13
Additional studies of the disc characteristics of the TSP-2-null mouse are needed to determine whether there are ultrastructural changes in collagen fibers similar to those seen in the tendons of TSP-2-null mice (that is, increased numbers of large-diameter fibrils) and to determine whether there is decreased tensile strength in TSP-2-null discs.


Regulation (changes) of collagen in tendons
19) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575610 Disease Relevance 0.32 Pain Relevance 0.12
In the case of qualitative collagen defects (ie, a structural alteration in the type I collagen molecule), mutations (typically glycine substitutions) in the collagen genes are associated with more severe or lethal phenotypes.
Regulation (alteration) of collagen
20) Confidence 0.04 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2940745 Disease Relevance 0.28 Pain Relevance 0

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