INT65262

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Context Info
Confidence 0.74
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 47
Total Number 48
Disease Relevance 36.59
Pain Relevance 5.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Lox) extracellular region (Lox) proteinaceous extracellular matrix (Lox)
nucleus (Lox)
Anatomy Link Frequency
pancreatic islets 2
endothelium 2
mesenchyme 1
cartilage 1
cochlear 1
Lox (Mus musculus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 232 99.92 Very High Very High Very High
fibrosis 129 99.28 Very High Very High Very High
Inflammation 214 98.64 Very High Very High Very High
Endocannabinoid 44 97.48 Very High Very High Very High
Lasting pain 10 96.60 Very High Very High Very High
ischemia 9 93.56 High High
cytokine 106 92.16 High High
Osteoarthritis 11 91.92 High High
cINOD 418 91.60 High High
aspirin 215 91.12 High High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 1932 100.00 Very High Very High Very High
Metastasis 417 100.00 Very High Very High Very High
Breast Cancer 94 99.78 Very High Very High Very High
Apoptosis 927 99.72 Very High Very High Very High
Cancer 2447 99.64 Very High Very High Very High
Prostate Cancer 138 99.60 Very High Very High Very High
Fibrosis 63 99.48 Very High Very High Very High
Cystic Fibrosis 105 99.28 Very High Very High Very High
Adenocarcinoma 191 98.80 Very High Very High Very High
INFLAMMATION 244 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In blood vessels LOX is expressed both the endothelium and the vascular smooth muscle cells [14], [45], [46], [47]; LOX expression is also upregulated in invasive breast cancer cells [22], [23].
Gene_expression (expression) of LOX in endothelium associated with breast cancer
1) Confidence 0.74 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680032 Disease Relevance 0.64 Pain Relevance 0
Both up- and down-regulation of LOX has been observed in different cancer cell lines and primary tumors (reviewed in [21]), however, in breast cancer, elevated LOX expression has been positively-correlated with invasiveness, as well as with reduced metastasis-free and overall survival [16], [22], [23], [24], [25].
Gene_expression (expression) of LOX associated with cancer, breast cancer and metastasis
2) Confidence 0.74 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680032 Disease Relevance 1.12 Pain Relevance 0.04
Although COX-1, COX-2, and LOX are expressed in cochlea, their roles played in cochlear acoustic injury have not fully been evaluated.
Gene_expression (expressed) of LOX in cochlear associated with injury
3) Confidence 0.72 Published 2008 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 18719338 Disease Relevance 0.59 Pain Relevance 0.37
In blood vessels LOX is expressed both the endothelium and the vascular smooth muscle cells [14], [45], [46], [47]; LOX expression is also upregulated in invasive breast cancer cells [22], [23].
Gene_expression (expressed) of LOX in endothelium associated with breast cancer
4) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680032 Disease Relevance 0.69 Pain Relevance 0
In addition, increased LOX expression has been correlated with decreases in both metastases-free, and overall survival in breast cancer patients.
Gene_expression (expression) of LOX associated with breast cancer and metastasis
5) Confidence 0.57 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2680032 Disease Relevance 0.61 Pain Relevance 0.03
LOX activity is expressed as fluorescent units.


Gene_expression (expressed) of LOX
6) Confidence 0.48 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 0.06 Pain Relevance 0
Indeed, the expression level of this LOX has been shown to increase in bronchial tissues of CF patients [27].
Gene_expression (expression) of LOX associated with fibrosis
7) Confidence 0.45 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.22 Pain Relevance 0.21
/lox and IL-4R??
Gene_expression (/) of lox
8) Confidence 0.44 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.21 Pain Relevance 0.13
Indeed, the Thy1high subset is distinguished by a nearly exclusive expression of Col1a1, Slit3, and Lox, and as expected from FACS analysis, by Sca1 (Figure 8C).
Gene_expression (expression) of Lox
9) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0 Pain Relevance 0
This discrepancy might be due to differences in the expression levels of LOX, COX and PGES in CF patients compared to CF mice.
Gene_expression (expression) of LOX associated with fibrosis
10) Confidence 0.39 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.88 Pain Relevance 0.31
When we compared microarray data for two clones, G-2C9 and G-2C11, with parental G-2 cells as a reference, we observed that the list of genes weaker expressed in the subclones (FC>3; list of genes is in Table S1) includes the Thy1 gene and genes coding for the transcription factor Twist2, which promotes metastatic spreading [38], the secreted protein Slit3, which is expressed in mammary gland [39] and fetal lung mesenchyme [40], the lysyl oxidase (Lox) involved in the crosslinking of collagens and the formation of a premetastatic niche [41], and several collagen-coding genes (Col1a1, Col1a2, Col5a1, Col5a2, Col8a1 and Col12a1).
Gene_expression (expressed) of Lox in mesenchyme
11) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.06 Pain Relevance 0
To further elucidate the lack of beneficial effects of sEH inhibition on the progression of chronic renal failure, we investigated the pro-inflammatory lipoxygenase system. 5/6-Nx had no significant effect on the renal expression of 5-Lox and 12-Lox, whereas a trend towards increased expression of 15-Lox was observed.
Gene_expression (expression) of Lox associated with chronic renal failure and inflammation
12) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2915917 Disease Relevance 0.20 Pain Relevance 0.08
To further elucidate the lack of beneficial effects of sEH inhibition on the progression of chronic renal failure, we investigated the pro-inflammatory lipoxygenase system. 5/6-Nx had no significant effect on the renal expression of 5-Lox and 12-Lox, whereas a trend towards increased expression of 15-Lox was observed.
Gene_expression (expression) of Lox associated with chronic renal failure and inflammation
13) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2915917 Disease Relevance 0.20 Pain Relevance 0.08
Expression of LOX is also up-regulated in both adenocarcinomas and early neoplastic lesions of the pancreas.
Gene_expression (Expression) of LOX in pancreas associated with adenocarcinoma
14) Confidence 0.33 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 0.97 Pain Relevance 0.05
Interestingly, a strong positive interplay exists between 15-LOX-products and the pro-fibrotic transforming growth factor ?
Gene_expression (products) of LOX associated with fibrosis
15) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2915917 Disease Relevance 1.24 Pain Relevance 0.21
Indeed, the levels of LTB4 and cysteinyl-leukotrienes (LTC4/D4/E4), the products of AA via LOX, are similar in CFTR-/- compared to CFTR +/+ mice.
Gene_expression (levels) of LOX
16) Confidence 0.31 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.20 Pain Relevance 0.21
Clinically, the degree of 12-LOX expression in human prostate cancer correlates with the tumor grade and stage and 12-LOX expression level is higher in metastatic prostate cancers than in nonmetastatic ones [23].
Gene_expression (expression) of LOX associated with cancer and prostate cancer
17) Confidence 0.29 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.36 Pain Relevance 0
Whether 15-LOX and 8-LOX are expressed in pancreatic cancer or in normal pancreatic tissues has not been investigated.


Gene_expression (expressed) of LOX associated with pancreatic cancer
18) Confidence 0.29 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.34 Pain Relevance 0.11
It also appears that levels of 5-LOX in hepatic metastases of pancreatic cancer express more 5-LOX than the primary tumors [46].
Gene_expression (express) of LOX associated with cancer, pancreatic cancer and metastasis
19) Confidence 0.29 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.21 Pain Relevance 0.03
We recently explored the effect of LOX inhibition on pancreatic cancer cell proliferation and survival using pharmacological LOX inhibitors and a FLAP inhibitor, as well as antisense oligonucleotides targeting 5-LOX, 12-LOX or 15-LOX expression [45,52].
Gene_expression (expression) of LOX associated with pancreatic cancer
20) Confidence 0.29 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.12 Pain Relevance 0.08

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