INT65263

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Context Info
Confidence 0.69
First Reported 1996
Last Reported 2010
Negated 2
Speculated 7
Reported most in Abstract
Documents 61
Total Number 68
Disease Relevance 25.69
Pain Relevance 14.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Anatomy Link Frequency
sensory neurons 22
skin 10
liver 8
hair 8
brains 6
Igf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 155 100.00 Very High Very High Very High
cytokine 42 100.00 Very High Very High Very High
qutenza 131 99.98 Very High Very High Very High
Hippocampus 38 99.68 Very High Very High Very High
Somatostatin 73 99.20 Very High Very High Very High
dorsal root ganglion 15 98.56 Very High Very High Very High
Inflammation 77 95.04 Very High Very High Very High
COX-2 inhibitor 3 92.72 High High
sodium channel 5 92.60 High High
antagonist 20 91.72 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 176 100.00 Very High Very High Very High
Frailty 104 100.00 Very High Very High Very High
Disease 100 100.00 Very High Very High Very High
Body Weight 59 100.00 Very High Very High Very High
Chronic Renal Failure 29 100.00 Very High Very High Very High
Apoptosis 88 99.92 Very High Very High Very High
Alopecia 57 99.92 Very High Very High Very High
Cognitive Disorder 53 99.92 Very High Very High Very High
Pathologic Neovascularization 5 99.92 Very High Very High Very High
Salivary Gland Disease 4 99.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These observations raise the possibility that administration of capsaicin and isoflavone might promote hair growth by increasing IGF-I production.
Positive_regulation (increasing) of Gene_expression (production) of IGF-I in hair associated with qutenza and alopecia
1) Confidence 0.69 Published 2007 Journal Growth Horm. IGF Res. Section Abstract Doc Link 17569567 Disease Relevance 0.33 Pain Relevance 0.43
To evaluate whether insulin-like growth factor-I (IGF-I) modulates neural activity in vivo, relative levels of brain [3H]2-deoxyglucose (2DG) uptake were compared in adult behaving and anesthetized wild type (wt) mice, and transgenic (Tg) mice with either brain IGF-I overexpression or ectopic brain expression of IGF binding protein-1 (IGFBP-1).
Positive_regulation (overexpression) of Gene_expression (overexpression) of IGF-I in neural associated with targeted disruption
2) Confidence 0.69 Published 1997 Journal Neuroreport Section Abstract Doc Link 9376529 Disease Relevance 0.53 Pain Relevance 0.08
Increased neural activity in transgenic mice with brain IGF-I overexpression: a [3H]2DG study.
Positive_regulation (overexpression) of Gene_expression (overexpression) of IGF-I in brain associated with targeted disruption
3) Confidence 0.69 Published 1997 Journal Neuroreport Section Title Doc Link 9376529 Disease Relevance 0.52 Pain Relevance 0.08
These observations suggested that capsaicin-induced sensory neuron activation, which leads to release of CGRP, might increase IGF-I production, thereby reducing reperfusion-induced liver injury by reducing apoptosis.
Spec (might) Positive_regulation (increase) of Gene_expression (production) of IGF-I in liver associated with qutenza, injury, apoptosis and calcitonin gene-related peptide
4) Confidence 0.69 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17360009 Disease Relevance 0.70 Pain Relevance 0.78
We examined whether stimulation of sensory neurons by capsaicin might reduce reperfusion-induced hepatic apoptosis by increasing IGF-I production.
Positive_regulation (increasing) of Gene_expression (production) of IGF-I in sensory neurons associated with qutenza and apoptosis
5) Confidence 0.69 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17360009 Disease Relevance 0.50 Pain Relevance 0.67
These observations strongly suggest that GG increases the production of IGF-I in the skin through sensory neuron stimulation, thereby increasing skin elasticity.
Positive_regulation (increases) of Gene_expression (production) of IGF-I in sensory neuron
6) Confidence 0.69 Published 2010 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 20378988 Disease Relevance 0.34 Pain Relevance 0.18
In this study, we examined whether topical application of alpha-D-glucosylglycerol (GG), a compound found in Japanese traditional brewed foods such as sake (Japanese rice wine), increases the dermal production of IGF-I in mice and increases the facial skin elasticity in females.
Spec (whether) Positive_regulation (increases) of Gene_expression (production) of IGF-I in skin
7) Confidence 0.69 Published 2010 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 20378988 Disease Relevance 0.31 Pain Relevance 0.21
These observations strongly suggest that the stimulation of sensory neurons by capsaicin might increase IGF-I production via increasing the hippocampal tissue CGRP levels, and it may thereby promote angiogenesis and neurogenesis to produce improvement of the cognitive function in mice.
Spec (might) Positive_regulation (increase) of Gene_expression (production) of IGF-I in sensory neurons associated with cognitive disorder, qutenza, neurodegenerative disease and calcitonin gene-related peptide
8) Confidence 0.69 Published 2009 Journal Transl Res Section Abstract Doc Link 19595440 Disease Relevance 0.45 Pain Relevance 1.18
In the current study, we examined whether stimulation of sensory neurons by capsaicin improved the cognitive function by increasing the production of IGF-I in the hippocampus using wild-type (WT) and CGRP-knockout (CGRP-/-) mice.
Spec (whether) Positive_regulation (increasing) of Gene_expression (production) of IGF-I in sensory neurons associated with targeted disruption, cognitive disorder, qutenza, hippocampus and calcitonin gene-related peptide
9) Confidence 0.69 Published 2009 Journal Transl Res Section Abstract Doc Link 19595440 Disease Relevance 0.52 Pain Relevance 0.84
Since CGRP increases production of insulin-like growth factor-I (IGF-I) in fetal osteoblasts in vitro, it is possible that sensory neuron activation by capsaicin increases production of IGF-I.
Spec (possible) Positive_regulation (increases) of Gene_expression (production) of IGF-I in sensory neuron associated with qutenza and calcitonin gene-related peptide
10) Confidence 0.68 Published 2007 Journal Growth Horm. IGF Res. Section Abstract Doc Link 17307377 Disease Relevance 0 Pain Relevance 0.66
Administration of capsaicin and isoflavone increases IGF-I production in hair follicles, thereby promoting hair growth in mice and in volunteers with alopecia.
Positive_regulation (increases) of Gene_expression (production) of IGF-I in hair associated with qutenza and alopecia
11) Confidence 0.68 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 19075656 Disease Relevance 0.72 Pain Relevance 0.54
This sensory neuron-mediated IGF-I production contributes to reducing reperfusion-induced liver injury through prevention of apoptosis in mice.
Positive_regulation (mediated) of Gene_expression (production) of IGF-I in liver associated with injury and apoptosis
12) Confidence 0.68 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 19075656 Disease Relevance 0.47 Pain Relevance 0.42
IGF-1 overexpression—though not directly comparable to systemically elevated IGF-1/GH levels—has been reported to lead to markedly increased brain size in mice [22], whereas IGF-1 knockout mice showed smaller brains [15].
Positive_regulation (overexpression) of Gene_expression (overexpression) of IGF-1 in brains associated with targeted disruption
13) Confidence 0.68 Published 2008 Journal Pituitary Section Body Doc Link PMC2712618 Disease Relevance 0.33 Pain Relevance 0.06
Topical application of 0.01% RK increased immunohistochemical expression of IGF-I at dermal papillae in hair follicles and promoted hair re-growth in WT mice at 4 weeks after the application.
Positive_regulation (increased) of Gene_expression (expression) of IGF-I in hair
14) Confidence 0.66 Published 2008 Journal Growth Horm. IGF Res. Section Abstract Doc Link 18321745 Disease Relevance 0.57 Pain Relevance 0.33
We have reported that topical application of capsaicin increases facial skin elasticity by increasing the production of dermal insulin-like growth factor-I (IGF-I) through stimulation of sensory neurons in mice and humans.
Positive_regulation (increasing) of Gene_expression (production) of insulin-like growth factor-I in sensory neurons associated with qutenza
15) Confidence 0.60 Published 2010 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 20378988 Disease Relevance 0.13 Pain Relevance 0.17
We recently reported that topical application of capsaicin increases facial skin elasticity and promotes hair growth by increasing dermal insulin-like growth factor-I (IGF-I) production through activation of sensory neurons in mice and humans.
Positive_regulation (increasing) of Gene_expression (production) of insulin-like growth factor-I in skin associated with qutenza and alopecia
16) Confidence 0.58 Published 2008 Journal Growth Horm. IGF Res. Section Abstract Doc Link 18321745 Disease Relevance 0.31 Pain Relevance 0.34
Expression of IGF-1 was increased in the vitreous of patients with diabetic retinopathy (39).
Positive_regulation (increased) of Gene_expression (Expression) of IGF-1 associated with diabetic retinopathy
17) Confidence 0.57 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.85 Pain Relevance 0
In this study, IGF-I production was inactivated in the liver of adult mice (LI-IGF-I(-/-)), resulting in an approximately 80-85% reduction of circulating IGF-I concentrations.
Positive_regulation (inactivated) of Gene_expression (production) of IGF-I in liver
18) Confidence 0.50 Published 2006 Journal J. Endocrinol. Section Abstract Doc Link 16731792 Disease Relevance 0.19 Pain Relevance 0.08
We have reported that topical application of capsaicin increases facial skin elasticity by increasing the production of dermal insulin-like growth factor-I (IGF-I) through stimulation of sensory neurons in mice and humans.
Positive_regulation (increasing) of Gene_expression (production) of IGF-I in sensory neurons associated with qutenza
19) Confidence 0.50 Published 2010 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 20378988 Disease Relevance 0.14 Pain Relevance 0.17
Administration of capsaicin increases CGRP and IGF-I levels in plasma, kidneys and the heart in SHR to WKY levels, and normalizes mean arterial blood pressure in SHR.
Positive_regulation (increases) of Gene_expression (levels) of IGF-I in blood associated with qutenza and calcitonin gene-related peptide
20) Confidence 0.49 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 19075656 Disease Relevance 0.69 Pain Relevance 0.52

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