INT65265

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Context Info
Confidence 0.69
First Reported 1996
Last Reported 2010
Negated 7
Speculated 1
Reported most in Body
Documents 48
Total Number 49
Disease Relevance 23.81
Pain Relevance 6.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Col7a1) cell adhesion (Col7a1) proteinaceous extracellular matrix (Col7a1)
Anatomy Link Frequency
lung 8
skin 6
fibroblast 4
macrophages 2
ventricle 2
Col7a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 149 100.00 Very High Very High Very High
fibrosis 334 99.32 Very High Very High Very High
Pain 33 98.72 Very High Very High Very High
metalloproteinase 52 98.68 Very High Very High Very High
anesthesia 35 98.60 Very High Very High Very High
halothane 5 98.16 Very High Very High Very High
agonist 10 98.00 Very High Very High Very High
Inflammation 470 97.76 Very High Very High Very High
rheumatoid arthritis 302 96.52 Very High Very High Very High
cytokine 297 95.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Arthritis 150 100.00 Very High Very High Very High
Immunization 38 100.00 Very High Very High Very High
Hyperplasia 20 100.00 Very High Very High Very High
Contracture 13 99.88 Very High Very High Very High
Osteogenesis Imperfecta 448 99.82 Very High Very High Very High
Apoptosis 93 99.80 Very High Very High Very High
Fibrosis 388 99.56 Very High Very High Very High
Wound Healing 91 99.48 Very High Very High Very High
Injury 160 99.32 Very High Very High Very High
Atherosclerosis 56 99.22 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A significant increase of collagen synthesis was observed in group L compared with C (168 +/- 20 vs 63 +/- 8 mm(2)).
Positive_regulation (increase) of Gene_expression (synthesis) of collagen
1) Confidence 0.69 Published 2007 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 17581688 Disease Relevance 0.53 Pain Relevance 0.26
Collagen, expressed per weight of tissue, was significantly increased in all tissues from high-growth mice, as was collagen cross-linking, expressed as moles of cross-link per mole of collagen.
Positive_regulation (increased) of Gene_expression (expressed) of Collagen
2) Confidence 0.62 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8853393 Disease Relevance 0 Pain Relevance 0.18
Expression of types I and III collagen, lysyl oxidase, and lysyl hydroxylase was increased in all tissues analyzed.
Positive_regulation (increased) of Gene_expression (Expression) of collagen
3) Confidence 0.54 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8853393 Disease Relevance 0 Pain Relevance 0.18
These results suggest that 1) elevated circulating IGF-1 may increase collagen deposition both in normal tissue as well as in granulation tissue by increasing collagen gene expression, 2) IGF-1 may increase collagen cross-linking by stimulating expression of lysyl oxidase, and 3) the preferential increase in dihydroxylated cross-links observed in high-growth mice may be due to the stimulation of lysyl hydroxylase expression by IGF-1.
Positive_regulation (increasing) of Gene_expression (expression) of collagen in granulation
4) Confidence 0.54 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8853393 Disease Relevance 0 Pain Relevance 0.15
Ulrich et al35 found that the balance between MMPs and TIMPs is disturbed in patients with capsule contracture thus causing alteration in synthesis and deposition of collagen surrounding implants.36
Positive_regulation (causing) of Gene_expression (synthesis) of collagen in capsule associated with metalloproteinase and contracture
5) Confidence 0.28 Published 2010 Journal Eplasty Section Body Doc Link PMC2948451 Disease Relevance 0.70 Pain Relevance 0.43
These included several collagen-encoding genes; collagen I ?
Positive_regulation (several) of Gene_expression (several) of collagen
6) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0.44 Pain Relevance 0.09
In mice receiving ethanol plus cerulein, there was increased collagen deposition as compared with other treatment groups as well as increased frequency of alpha-smooth muscle actin and desmin-positive PSC, which also showed significantly enhanced CTGF protein production.
Positive_regulation (increased) of Gene_expression (deposition) of collagen in PSC associated with primary sclerosing cholangitis
7) Confidence 0.14 Published 2010 Journal Lab. Invest. Section Abstract Doc Link 20368699 Disease Relevance 1.26 Pain Relevance 0.62
signaling, which generally induces collagen production.
Positive_regulation (induces) of Gene_expression (production) of collagen
8) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.31 Pain Relevance 0
RESULTS: Halofuginone prevented cerulein-dependent increase in collagen synthesis, collagen cross-linking enzyme P4Hbeta, Cygb/STAP, and tissue inhibitors of metalloproteinase 2.
Positive_regulation (increase) of Gene_expression (synthesis) of collagen
9) Confidence 0.13 Published 2009 Journal Pancreas Section Body Doc Link 19188864 Disease Relevance 0.08 Pain Relevance 0
Also the collagen-induced IL-4 production in the IFA:collagen-immunized control mice was significantly greater than that in the mice that received unprocessed grafts.
Positive_regulation (-) of Gene_expression (production) of collagen
10) Confidence 0.10 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1459156 Disease Relevance 0.08 Pain Relevance 0.08
siRNAs of SPARC and Ctgf attenuated over-expression of collagen and other fibrotic ECM genes induced by bleomycin in skin and lung tissues
Positive_regulation (expression) of Gene_expression (over) of collagen in skin associated with fibrosis
11) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.10 Pain Relevance 0
siRNAs of SPARC and Ctgf attenuated over-expression of collagen and other fibrotic ECM genes induced by bleomycin in skin and lung tissues
Positive_regulation (over) of Gene_expression (over) of collagen in skin associated with fibrosis
12) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.10 Pain Relevance 0
ELISA testing showed, after four weeks, production of human collagen-specific IgG antibodies was not induced in the sham-operated negative control mice, however, these mice demonstrated elevated levels of IgM antibodies.
Neg (not) Positive_regulation (induced) of Gene_expression (production) of collagen
13) Confidence 0.08 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1459156 Disease Relevance 0.06 Pain Relevance 0.10
Two types of approach have been attempted in the GH treatment of OI, one is an extensive, general stimulus of bone metabolism, the other, based on more stringent criteria, stimulates collagen synthesis in cases of ascertained quantitative deficiency.
Positive_regulation (stimulates) of Gene_expression (synthesis) of collagen associated with osteogenesis imperfecta
14) Confidence 0.07 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2940745 Disease Relevance 0.92 Pain Relevance 0.05
The effects of taurine (T) and niacin (N) on bleomycin (BL)-induced increased production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1alpha, IL-6, and transforming growth factor-beta (TGF-beta) levels in the bronchoalveolar lavage fluid (BALF), and increased collagen content and nuclear factor-kappaB (NF-kappaB) activation in the lungs were investigated in mice.
Positive_regulation (increased) of Gene_expression (content) of collagen in lungs associated with necrosis and cancer
15) Confidence 0.07 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10734156 Disease Relevance 0.34 Pain Relevance 0.16
In response to the photooxidized human grafts, there was no elevated human collagen-specific total IgG and IgG2a production, while a weak IgG1 response was observed in two of eight mice.
Neg (no) Positive_regulation (elevated) of Gene_expression (production) of collagen
16) Confidence 0.07 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1459156 Disease Relevance 0 Pain Relevance 0.08
Also the collagen-induced IL-4 production in the IFA:collagen-immunized control mice was significantly greater than that in the mice that received unprocessed grafts.
Positive_regulation (induced) of Gene_expression (production) of collagen
17) Confidence 0.07 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1459156 Disease Relevance 0.08 Pain Relevance 0.08
The numbers of collagen-specific IFN-?
Positive_regulation (numbers) of Gene_expression (numbers) of collagen
18) Confidence 0.07 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1459156 Disease Relevance 0 Pain Relevance 0.10
Taken together, our data on vascular matrix integrity and expression of the major matrix molecules indicate that although both collagen and elastin production was stimulated in SMC, the even greater increase in MMP activity in both inflammatory cells and SMC resulted in exceeding elastolysis and collagenolysis and thus a dramatic loss of structural integrity.
Positive_regulation (stimulated) of Gene_expression (production) of collagen associated with inflammation
19) Confidence 0.07 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2933604 Disease Relevance 0.28 Pain Relevance 0.14
Zymography (Fig. 3F) revealed massive matrixmetalloproteinase activity at the intima-media border (rich in activated 27F10-positive inflammatory cells) and in association with clusters of CD68-positive macrophages in deeper medial areas. mRNA-expression analysis revealed a distinct increase in the expression profiles of the major vascular collagens (collagen type I, III, and VIII), which were expressed about 1.5 - 2-fold higher than in healthy control tissues.
Positive_regulation (increase) of Gene_expression (expression) of collagen in macrophages associated with inflammation
20) Confidence 0.07 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2933604 Disease Relevance 0.29 Pain Relevance 0.15

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