INT65266

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Context Info
Confidence 0.17
First Reported 1996
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Plod3) endoplasmic reticulum (Plod3)
Anatomy Link Frequency
granulation 1
Plod3 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 2 90.84 High High
halothane 2 90.40 High High
alcohol 2 82.32 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of types I and III collagen, lysyl oxidase, and lysyl hydroxylase was increased in all tissues analyzed.
Gene_expression (Expression) of lysyl hydroxylase
1) Confidence 0.17 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8853393 Disease Relevance 0 Pain Relevance 0.18
These results suggest that 1) elevated circulating IGF-1 may increase collagen deposition both in normal tissue as well as in granulation tissue by increasing collagen gene expression, 2) IGF-1 may increase collagen cross-linking by stimulating expression of lysyl oxidase, and 3) the preferential increase in dihydroxylated cross-links observed in high-growth mice may be due to the stimulation of lysyl hydroxylase expression by IGF-1.
Gene_expression (expression) of lysyl hydroxylase in granulation
2) Confidence 0.17 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8853393 Disease Relevance 0 Pain Relevance 0.13

General Comments

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