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Context Info
Confidence 0.42
First Reported 1996
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Igf1, Col7a1) extracellular space (Igf1) cell adhesion (Col7a1)
proteinaceous extracellular matrix (Col7a1)
Anatomy Link Frequency
granulation 2
Igf1 (Mus musculus)
Col7a1 (Mus musculus)
Pain Link Frequency Relevance Heat
alcohol 1 88.16 High High
anesthesia 1 66.84 Quite High
halothane 1 66.40 Quite High


Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that 1) elevated circulating IGF-1 may increase collagen deposition both in normal tissue as well as in granulation tissue by increasing collagen gene expression, 2) IGF-1 may increase collagen cross-linking by stimulating expression of lysyl oxidase, and 3) the preferential increase in dihydroxylated cross-links observed in high-growth mice may be due to the stimulation of lysyl hydroxylase expression by IGF-1.
IGF-1 Positive_regulation (increase) of collagen Binding (cross-linking) of in granulation
1) Confidence 0.42 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8853393 Disease Relevance 0 Pain Relevance 0.14

General Comments

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