INT65284

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Context Info
Confidence 0.52
First Reported 1996
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 7
Total Number 13
Disease Relevance 5.93
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pc) ligase activity (Pc)
Anatomy Link Frequency
PCx 2
Pc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
endometriosis 623 99.42 Very High Very High Very High
depression 12 96.36 Very High Very High Very High
Inflammation 19 95.84 Very High Very High Very High
Pain 26 84.84 Quite High
lidocaine 6 82.96 Quite High
Potency 8 81.60 Quite High
Lasting pain 6 78.56 Quite High
cytokine 2 49.36 Quite Low
ischemia 10 43.96 Quite Low
tolerance 1 30.04 Quite Low
Disease Link Frequency Relevance Heat
Chronic Disease 7 99.80 Very High Very High Very High
Disease 115 99.68 Very High Very High Very High
Endometriosis (extended) 630 99.42 Very High Very High Very High
Depression 12 96.36 Very High Very High Very High
INFLAMMATION 16 95.84 Very High Very High Very High
Pain 12 84.84 Quite High
Recurrence 7 83.36 Quite High
Premature Birth 28 81.92 Quite High
Spontaneous Abortion 64 79.60 Quite High
Endometriosis 63 76.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is also possible that other unidentified behavioral changes may be made as a result of an endometriosis diagnosis; if these changes affect PCB levels, they may have impacted our study results.
Regulation (affect) of PCB associated with endometriosis
1) Confidence 0.52 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944090 Disease Relevance 0.63 Pain Relevance 0.16
If PCB concentrations are affected by the disease, measured exposure levels may not be representative of past exposure occurring during a postulated period of causation.
Regulation (affected) of PCB associated with disease
2) Confidence 0.52 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944090 Disease Relevance 0.90 Pain Relevance 0.21
Taken in context with results of other recent North American studies, our findings indicate that PCB concentrations consistent within the range of exposure currently observed in western Washington State do not contribute meaningfully to endometriosis risk.
Neg (not) Regulation (contribute) of PCB associated with endometriosis
3) Confidence 0.38 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944090 Disease Relevance 0.58 Pain Relevance 0.23
Furthermore, we conducted analyses of individual PCB congeners in addition to ?
Spec (analyses) Regulation (analyses) of PCB
4) Confidence 0.38 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944090 Disease Relevance 0.49 Pain Relevance 0.20
To assess a linear trend of the association between endometriosis risk and PCB concentration, we also fit models using the natural log-transformed continuous values for each PCB congener.
Regulation (values) of PCB associated with endometriosis
5) Confidence 0.38 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944090 Disease Relevance 0.10 Pain Relevance 0.05
The concentrations of PeCDF, PCB-126, and PCB-169 gradually decreased each year, but the mean concentrations of PeCDF, PCB-126, and PCB-169 in pregnancies during 1988–2003 were about 2- to 5-fold greater than those of the general population.
Regulation (concentrations) of PCB
6) Confidence 0.25 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2367658 Disease Relevance 0.31 Pain Relevance 0
Weight change, which may affect PCB levels, is not a typical symptom of endometriosis onset; therefore, we do not consider this type of exposure misclassification to be likely.
Spec (may) Regulation (affect) of PCB associated with endometriosis
7) Confidence 0.23 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944090 Disease Relevance 0.89 Pain Relevance 0.20
Conversion to moles per gram was accomplished by dividing the wet-weight PCB value by the molecular weight for each congener.
Regulation (value) of PCB
8) Confidence 0.23 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944090 Disease Relevance 0.08 Pain Relevance 0.08
The PCx control was tested by blocking in a transient and reversible manner, using the cortical spreading depression (CSD).
Regulation (control) of PCx in PCx associated with depression
9) Confidence 0.22 Published 1996 Journal Arch. Med. Res. Section Abstract Doc Link 8854381 Disease Relevance 0.52 Pain Relevance 0.43
This study shows the tonic facilitatory control of the PCx upon intralaminar thalamic noxious responses, during acute and subacute stages of carrageenin produced-inflammation.
Regulation (control) of PCx in PCx associated with inflammation
10) Confidence 0.22 Published 1996 Journal Arch. Med. Res. Section Abstract Doc Link 8854381 Disease Relevance 0.81 Pain Relevance 0.68
The concentrations of PeCDF, PCB-126, and PCB-169 gradually decreased each year, but the mean concentrations of PeCDF, PCB-126, and PCB-169 in pregnancies during 1988–2003 were about 2- to 5-fold greater than those of the general population.
Regulation (concentrations) of PCB
11) Confidence 0.21 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2367658 Disease Relevance 0.31 Pain Relevance 0
The lowest effective dose of PCB-153 administered alone is much greater than 2,000 ?
Regulation (effective) of PCB-153
12) Confidence 0.17 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1310917 Disease Relevance 0 Pain Relevance 0
Moreover, Bcl2 expression was reduced in females exposed to A1254 at the neuroprotective dose of 0.1 mg/kg/day, suggesting that Bcl2 up-regulation is not required for PCB effects on infarct volume in these animals.
Regulation (effects) of PCB
13) Confidence 0.16 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.31 Pain Relevance 0

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