INT65295

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Context Info
Confidence 0.37
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 6.36
Pain Relevance 6.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bdkrb2) plasma membrane (Bdkrb2) signal transducer activity (Bdkrb2)
Anatomy Link Frequency
nerve 1
kidney 1
Bdkrb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
B1 receptor 184 100.00 Very High Very High Very High
bradykinin 58 100.00 Very High Very High Very High
antagonist 38 100.00 Very High Very High Very High
b2 receptor 14 100.00 Very High Very High Very High
COX-2 inhibitor 4 100.00 Very High Very High Very High
Osteoarthritis 8 99.84 Very High Very High Very High
Analgesic 2 99.58 Very High Very High Very High
MU agonist 3 99.56 Very High Very High Very High
fibrosis 2 99.56 Very High Very High Very High
Intracerebroventricular 1 99.18 Very High Very High Very High
Disease Link Frequency Relevance Heat
Osteoarthritis 7 99.84 Very High Very High Very High
Diabetes Mellitus 34 99.78 Very High Very High Very High
Diabetes Complications 8 99.60 Very High Very High Very High
Internal Fibrosis 2 99.56 Very High Very High Very High
Hyperalgesia 6 98.50 Very High Very High Very High
Renal Disease 2 98.24 Very High Very High Very High
Fever 3 98.16 Very High Very High Very High
Neuropathic Pain 54 97.60 Very High Very High Very High
Pressure And Volume Under Development 43 97.36 Very High Very High Very High
Aging 2 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate zaltoprofen may produce its analgesic effects through the inhibition of bradykinin B2 receptor-mediated bradykinin responses of not only cyclooxygenases (COXs) but also bradykinin induced 12-LOX inhibitors.
Negative_regulation (inhibition) of bradykinin B2 receptor associated with analgesic, b2 receptor and bradykinin
1) Confidence 0.37 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15857630 Disease Relevance 0.57 Pain Relevance 1.24
We have examined the effect of a tachykinin NK1 and a bradykinin B2 antagonist, and a mu-opioid agonist on plasma extravasation observed in response to two differing nerve stimulating parameters (10 V, 1 ms, 2 Hz and 25 V, 2 ms, 10 Hz).
Negative_regulation (antagonist) of bradykinin B2 in nerve associated with mu agonist, antagonist and bradykinin
2) Confidence 0.37 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9857952 Disease Relevance 0.40 Pain Relevance 0.60
Also, to compare the effect of a COX-2 inhibitor with that of a nonselective COX-1 and COX-2 inhibitor and B2 receptor antagonist.
Negative_regulation (inhibitor) of B2 receptor associated with antagonist, b2 receptor and cox-2 inhibitor
3) Confidence 0.30 Published 2000 Journal Can J Anaesth Section Abstract Doc Link 10764183 Disease Relevance 0.26 Pain Relevance 0.46
JTE522 (1-100 mg x kg(-1)), a COX-2 inhibitor, indomethacin (1-30 mg x kg(-1)), a nonselective COX-1 and COX-2 inhibitor, or FR173657 (10 and 100 mg x kg(-1)), a bradykinin B2 receptor antagonist, was administered orally five minutes after the end of the surgery.
Negative_regulation (inhibitor) of bradykinin B2 receptor
4) Confidence 0.30 Published 2000 Journal Can J Anaesth Section Body Doc Link 10764183 Disease Relevance 0 Pain Relevance 0
In addition, genetically diabetic mice that lack the B2R develop a more severe kidney pathology by age 6 months and develop senescence-associated phenotypes by age 12 months [72], [73].
Negative_regulation (lack) of B2R in kidney associated with aging and diabetes mellitus
5) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 1.67 Pain Relevance 0.49
The lack of both kinin B1R and B2R enhances diabetic complications, including nephropathy and neuropathy in Akita diabetic mice [64].
Negative_regulation (lack) of B2R associated with diabetes mellitus, diabetes complications, b1 receptor, neuropathic pain and renal disease
6) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 1.76 Pain Relevance 0.53
This increase was sensitive to calcineurin and B2 receptor inhibition.
Negative_regulation (inhibition) of B2 receptor associated with b2 receptor
7) Confidence 0.20 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17485565 Disease Relevance 0.14 Pain Relevance 0.54
Development of hyperthermia and hyperalgesia following intracerebroventricular administration of endotoxin in the rat: effect of kinin B1 and B2 receptor antagonists.
Negative_regulation (effect) of B2 receptor associated with hyperalgesia, inflammation, antagonist, b2 receptor, fever and intracerebroventricular
8) Confidence 0.04 Published 1996 Journal Immunopharmacology Section Title Doc Link 8856160 Disease Relevance 0.47 Pain Relevance 0.85
Biochemical and preclinical evidence supporting the therapeutic relevance of B2 receptor blockade in OA pathophysiology are reviewed in this publication.
Negative_regulation (blockade) of B2 receptor associated with b2 receptor and osteoarthritis
9) Confidence 0.02 Published 2008 Journal Inflamm. Res. Section Abstract Doc Link 18787773 Disease Relevance 1.01 Pain Relevance 1.03
These results demonstrate that the activation of EP3 restores the response to BK by attenuating the desensitization of BK B2 receptor activity via Gi protein.
Negative_regulation (desensitization) of BK B2 receptor associated with b2 receptor and bradykinin
10) Confidence 0.02 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17176262 Disease Relevance 0.07 Pain Relevance 0.74

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