INT653

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Context Info
Confidence 0.59
First Reported 1975
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 67
Total Number 69
Disease Relevance 20.33
Pain Relevance 16.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (REN) extracellular space (REN) extracellular region (REN)
intracellular (REN) response to stress (REN)
Anatomy Link Frequency
plasma 12
blood 10
sympathetic 9
kidney 6
outflow 4
REN (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 101 100.00 Very High Very High Very High
antagonist 51 100.00 Very High Very High Very High
narcan 13 100.00 Very High Very High Very High
COX2 2 100.00 Very High Very High Very High
thoracic epidural anesthesia 2 99.98 Very High Very High Very High
agonist 17 99.78 Very High Very High Very High
cINOD 21 99.64 Very High Very High Very High
Dopamine 13 99.52 Very High Very High Very High
tetrodotoxin 2 99.44 Very High Very High Very High
substance P 11 99.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 79 100.00 Very High Very High Very High
Natriuresis 26 100.00 Very High Very High Very High
Pressure And Volume Under Development 61 99.90 Very High Very High Very High
Aging 4 99.76 Very High Very High Very High
Bartter Syndrome 12 99.68 Very High Very High Very High
Pressure Volume 2 Under Development 46 99.36 Very High Very High Very High
INFLAMMATION 23 99.36 Very High Very High Very High
Diuresis 16 99.20 Very High Very High Very High
Hypertrophy 4 99.06 Very High Very High Very High
Hyperkalemia 21 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in animals adenosine by intrarenal infusion decreases renal blood flow (RBF), glomerular filtration rate (GFR), urine flow, and causes an inhibition of renin secretion.
Negative_regulation (inhibition) of Localization (secretion) of renin in urine associated with adenocard
1) Confidence 0.59 Published 1990 Journal Anesth. Analg. Section Abstract Doc Link 2240636 Disease Relevance 0.59 Pain Relevance 0.30
Sympathetic neural blockade by thoracic epidural anesthesia suppresses renin release in response to arterial hypotension.
Negative_regulation (suppresses) of Localization (release) of renin in neural associated with pressure volume 2 under development and thoracic epidural anesthesia
2) Confidence 0.59 Published 1994 Journal Anesthesiology Section Title Doc Link 8017664 Disease Relevance 0.10 Pain Relevance 0.19
K-351 (0.3 mg/kg, i.v.) significantly decreased systemic blood pressure, heart rate, mesenteric blood flow, and renin secretion rate without change in renal blood flow.
Negative_regulation (decreased) of Localization (secretion) of renin in blood
3) Confidence 0.58 Published 1984 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 6149735 Disease Relevance 0.17 Pain Relevance 0
Renal denervation reduced renin secretion and prevented the suppression of renin secretion produced by intravenous clonidine.
Negative_regulation (prevented) of Localization (secretion) of renin associated with clonidine
4) Confidence 0.58 Published 1975 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1120965 Disease Relevance 0.58 Pain Relevance 0.72
Thus, these data are consistent with the hypothesis that the suppression of renin secretion by clonidine results from a centrally mediated decrease in renal sympathetic neural tone.
Negative_regulation (suppression) of Localization (secretion) of renin in sympathetic associated with clonidine
5) Confidence 0.58 Published 1975 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1120965 Disease Relevance 0.55 Pain Relevance 0.69
Studies concerning the mechanism of suppression of renin secretion by clonidine.
Negative_regulation (suppression) of Localization (secretion) of renin associated with clonidine
6) Confidence 0.58 Published 1975 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 1120965 Disease Relevance 0.49 Pain Relevance 0.56
Two series of experiments were performed in anesthetized dogs to test the hypothesis that the suppression of renin secretion by clonidine results from a centrally mediated decrease in the activity in the renal sympathetic nerves.
Negative_regulation (suppression) of in sympathetic Localization (secretion) of renin in nerves associated with clonidine
7) Confidence 0.58 Published 1975 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1120965 Disease Relevance 0.27 Pain Relevance 0.40
The role of intrarenal dopaminergic receptors has been studied: (a) Haloperidol (intrarenal perfusion of 50 mug/kg/min for 20 min) suppresses the renal vasodilation and renin hypersecretion induced by dopamine.
Negative_regulation (suppresses) of Localization (hypersecretion) of renin associated with dopamine and increased venous pressure under development
8) Confidence 0.58 Published 1975 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1175682 Disease Relevance 0.28 Pain Relevance 0.21
During treatment of hypertensive patients with clonidine, renal blood flow and glomerular filtration rate are well maintained, and renin secretion is reduced.
Negative_regulation (reduced) of Localization (secretion) of renin in blood associated with hypertension and clonidine
9) Confidence 0.58 Published 1980 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 6154836 Disease Relevance 0.36 Pain Relevance 0.40
Suppression of renin release by antagonism of endogenous opiates in the dog.
Negative_regulation (Suppression) of Localization (release) of renin associated with narcan and opiate
10) Confidence 0.58 Published 1986 Journal Am. J. Physiol. Section Title Doc Link 3515972 Disease Relevance 0.06 Pain Relevance 0.73
Renal denervation reduced renin secretion and prevented the suppression of renin secretion produced by intravenous clonidine.
Negative_regulation (reduced) of Localization (secretion) of renin associated with clonidine
11) Confidence 0.58 Published 1975 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1120965 Disease Relevance 0.59 Pain Relevance 0.72
These results support the hypothesis that the suppression of renin secretion by clonidine is a consequence of the decrease in sympathetic activity produced by this drug.
Negative_regulation (suppression) of Localization (secretion) of renin in sympathetic associated with clonidine
12) Confidence 0.58 Published 1976 Journal Clin Sci Mol Med Suppl Section Abstract Doc Link 1071584 Disease Relevance 0 Pain Relevance 0.27
Unilateral renal arterial infusion of sodium thiopental decreased the renin secretion rate and plasma norepinephrine concentration in renal vein, whereas an anesthetic dose of sodium thiopental administered intravenously increased the renin secretion rate.
Negative_regulation (decreased) of Localization (secretion) of renin in renal vein
13) Confidence 0.58 Published 1987 Journal Ren Physiol Section Abstract Doc Link 3331472 Disease Relevance 0.08 Pain Relevance 0.09
These observations suggest that propranolol may block intrarenal conversion of prorenin to active renin while also suppressing total renin release.
Negative_regulation (suppressing) of Localization (release) of renin
14) Confidence 0.58 Published 1977 Journal Lancet Section Abstract Doc Link 71600 Disease Relevance 0.13 Pain Relevance 0.17
Atenolol reduces renin secretion from the renin-angiotensin system and consequently decreases the production of angiotensin II and plasma aldosterone.
Negative_regulation (reduces) of Localization (secretion) of renin-angiotensin in plasma
15) Confidence 0.57 Published 1998 Journal Drugs Section Abstract Doc Link 9813739 Disease Relevance 0.67 Pain Relevance 0.16
The effect of phenylephrine on renin release was abolished by the intrarenal infusion of the alpha-antagonist phentolamine (50 micrograms/min), but was not affected by the intravenous administration of the PG synthetase inhibitor indomethacin (5 mg/kg).
Negative_regulation (abolished) of Localization (release) of renin associated with antagonist
16) Confidence 0.57 Published 1984 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 6200712 Disease Relevance 0 Pain Relevance 0.09
A cyclooxygenase inhibitor, indomethacin (5 mg/kg i.v.), also suppressed the 5-HT-induced renin release.
Negative_regulation (suppressed) of Localization (release) of renin
17) Confidence 0.57 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1905236 Disease Relevance 0 Pain Relevance 0.17
Mechanism of suppression of renin secretion by clonidine in the dog.
Negative_regulation (suppression) of Localization (secretion) of renin associated with clonidine
18) Confidence 0.55 Published 1978 Journal Circ. Res. Section Title Doc Link 620441 Disease Relevance 0.22 Pain Relevance 0.45
The mechanism by which clonidine suppresses renin secretion was investigated in pentobarbital-anesthetized dogs in which renal perfusion pressure was controlled by means of an aortic clamp.
Negative_regulation (suppresses) of Spec (investigated) Localization (secretion) of renin associated with clonidine
19) Confidence 0.55 Published 1978 Journal Circ. Res. Section Abstract Doc Link 620441 Disease Relevance 0.12 Pain Relevance 0.26
Taken together, these data support the hypothesis that the inhibition of renin secretion by clonidine results from a centrally mediated decrease in sympathetic neural activity.
Negative_regulation (inhibition) of Localization (secretion) of renin in neural associated with clonidine
20) Confidence 0.55 Published 1978 Journal Circ. Res. Section Abstract Doc Link 620441 Disease Relevance 0.19 Pain Relevance 0.36

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