INT65304

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Context Info
Confidence 0.70
First Reported 1996
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 34
Total Number 36
Disease Relevance 11.32
Pain Relevance 12.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (MC1R) plasma membrane (MC1R) signal transducer activity (MC1R)
Anatomy Link Frequency
melanocytes 12
skin 7
keratinocytes 7
fat 2
sebaceous glands 2
MC1R (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 458 100.00 Very High Very High Very High
Inflammatory response 1 99.92 Very High Very High Very High
Inflammation 8 94.48 High High
Neuropeptide 3 86.32 High High
agonist 3 86.00 High High
antagonist 1 82.80 Quite High
cytokine 14 74.64 Quite High
adenocard 1 38.96 Quite Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 55 99.80 Very High Very High Very High
INFLAMMATION 9 99.52 Very High Very High Very High
Melanoma 322 99.12 Very High Very High Very High
Shock 1 98.64 Very High Very High Very High
Cancer 49 98.40 Very High Very High Very High
Stress 3 97.92 Very High Very High Very High
Acne 10 97.80 Very High Very High Very High
Nevus 64 97.64 Very High Very High Very High
Death 7 96.38 Very High Very High Very High
Necrosis 13 96.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Epidermal melanocytes and keratinocytes respond to UVR by increasing their expression of alphaMSH and ACTH, which up-regulate the expression of MC1R, and consequently enhance the response of melanocytes to melanocortins.
Positive_regulation (up-regulate) of Gene_expression (expression) of MC1R in melanocytes associated with melanocortin 1 receptor
1) Confidence 0.70 Published 2005 Journal Mutat. Res. Section Abstract Doc Link 15748644 Disease Relevance 0.38 Pain Relevance 0.86
Increased in situ expression of melanocortin-1 receptor in sebaceous glands of lesional skin of patients with acne vulgaris.
Positive_regulation (Increased) of Gene_expression (expression) of melanocortin-1 receptor in sebaceous glands associated with melanocortin 1 receptor and acne
2) Confidence 0.70 Published 2007 Journal Exp. Dermatol. Section Title Doc Link 17576233 Disease Relevance 1.04 Pain Relevance 0.44
All samples were positive for MC1-R expression, but expression of the receptor gene did not correlate with that of tyrosinase.
Positive_regulation (positive) of Gene_expression (expression) of MC1-R
3) Confidence 0.69 Published 1999 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 10644013 Disease Relevance 0.92 Pain Relevance 0.06
Ultraviolet (UV) exposure induces an up-regulation of melanocortin-1 receptor (MC1R) expression in human skin and the alpha-melanocyte-stimulating hormone (alpha-MSH) may reduce UVB-induced DNA damage in normal human melanocytes.
Positive_regulation (induces) of Gene_expression (expression) of melanocortin-1 receptor in melanocytes associated with melanocortin 1 receptor
4) Confidence 0.69 Published 2007 Journal Photochem. Photobiol. Sci. Section Abstract Doc Link 17487313 Disease Relevance 0 Pain Relevance 0.42
Ultraviolet B irradiation, an inducer of differentiation, stimulated both proopiomelanocortin production and melanocortin receptor expression.
Positive_regulation (stimulated) of Gene_expression (expression) of melanocortin receptor
5) Confidence 0.69 Published 1999 Journal J. Invest. Dermatol. Section Abstract Doc Link 10383729 Disease Relevance 0 Pain Relevance 0.07
MC1R expression is not restricted to melanocytic cells and may be induced in keratinocytes after UVB exposure.
Spec (may) Positive_regulation (induced) of Gene_expression (expression) of MC1R in keratinocytes associated with melanocortin 1 receptor
6) Confidence 0.69 Published 2009 Journal Photochem. Photobiol. Section Abstract Doc Link 19656324 Disease Relevance 0.35 Pain Relevance 0.67
Enhanced expression of melanocortin-1 receptor (MC1-R) in normal human keratinocytes during differentiation: evidence for increased expression of POMC peptides near suprabasal layer of epidermis.
Positive_regulation (Enhanced) of Gene_expression (expression) of MC1-R in keratinocytes associated with melanocortin 1 receptor
7) Confidence 0.67 Published 1999 Journal J. Invest. Dermatol. Section Title Doc Link 10383729 Disease Relevance 0 Pain Relevance 0.10
In growth inhibition experiments, alphaMSH significantly reduced growth of wild type MC1R transfected cells, but had no effect on cells transfected with variant MC1R.
Positive_regulation (transfected) of Gene_expression (transfected) of MC1R associated with melanocortin 1 receptor
8) Confidence 0.50 Published 2002 Journal Oncogene Section Abstract Doc Link 12439754 Disease Relevance 0.80 Pain Relevance 1.13
For each continent, we checked whether the CDKN2A mutation carriers who were genotyped or not genotyped for MC1R differed in terms of melanoma affection status, sex, and age at examination and found that there was no difference (data not shown).
Neg (not) Spec (whether) Positive_regulation (genotyped) of Neg (not) Gene_expression (genotyped) of MC1R associated with melanocortin 1 receptor and melanoma
9) Confidence 0.50 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2957428 Disease Relevance 0.50 Pain Relevance 0.36
Moreover, the V92M variant may also be impaired in the desensitization and internalization of MC1R, two mechanisms that occur after exposure of G protein–coupled receptors, such as MC1R, to their ligands to arrest G protein signaling (39,42).
Positive_regulation (occur) of Gene_expression (exposure) of MC1R associated with melanocortin 1 receptor
10) Confidence 0.50 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2957428 Disease Relevance 0.26 Pain Relevance 0.79
All samples were positive for MC1-R expression, but expression of the receptor gene did not correlate with that of tyrosinase.
Positive_regulation (positive) of Gene_expression (expression) of MC1-R
11) Confidence 0.50 Published 1999 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 10644013 Disease Relevance 0.92 Pain Relevance 0.06
Using high-performance liquid chromatography coupled to tandem mass spectrometry, we investigated the formation and repair of DNA lesions in UVB-irradiated HaCaT cells stably transfected with the wild type MC1R gene (HaCaT-MC1R).
Positive_regulation (transfected) of Gene_expression (transfected) of MC1R associated with melanocortin 1 receptor
12) Confidence 0.50 Published 2007 Journal Photochem. Photobiol. Sci. Section Abstract Doc Link 17487313 Disease Relevance 0 Pain Relevance 0.52
Ultraviolet (UV) exposure induces an up-regulation of melanocortin-1 receptor (MC1R) expression in human skin and the alpha-melanocyte-stimulating hormone (alpha-MSH) may reduce UVB-induced DNA damage in normal human melanocytes.
Positive_regulation (up-regulation) of Gene_expression (expression) of MC1R in melanocytes associated with melanocortin 1 receptor
13) Confidence 0.50 Published 2007 Journal Photochem. Photobiol. Sci. Section Abstract Doc Link 17487313 Disease Relevance 0 Pain Relevance 0.42
Using high-performance liquid chromatography coupled to tandem mass spectrometry, we investigated the formation and repair of DNA lesions in UVB-irradiated HaCaT cells stably transfected with the wild type MC1R gene (HaCaT-MC1R).
Positive_regulation (transfected) of Gene_expression (transfected) of MC1R associated with melanocortin 1 receptor
14) Confidence 0.50 Published 2007 Journal Photochem. Photobiol. Sci. Section Abstract Doc Link 17487313 Disease Relevance 0 Pain Relevance 0.52
The production of proopiomelanocortin peptides and its gene expression were not induced significantly, but the binding ability of melanocortin receptor, as well as its gene expression were stimulated by Ca2+.
Positive_regulation (ability) of Gene_expression (expression) of melanocortin receptor
15) Confidence 0.50 Published 1999 Journal J. Invest. Dermatol. Section Abstract Doc Link 10383729 Disease Relevance 0 Pain Relevance 0.07
Enhanced expression of melanocortin-1 receptor (MC1-R) in normal human keratinocytes during differentiation: evidence for increased expression of POMC peptides near suprabasal layer of epidermis.
Positive_regulation (increased) of in epidermis Gene_expression (expression) of melanocortin-1 receptor in keratinocytes associated with melanocortin 1 receptor
16) Confidence 0.50 Published 1999 Journal J. Invest. Dermatol. Section Title Doc Link 10383729 Disease Relevance 0 Pain Relevance 0.10
Northern blot analysis showed that MC1-R mRNA expression was induced 24 h after UVB irradiation in a dose-dependent manner, and that 24-h treatment with ET-1 also induced an expression of MC1-R mRNA, whereas TNF-alpha downregulated the expression.
Positive_regulation (induced) of Gene_expression (expression) of MC1-R
17) Confidence 0.49 Published 1998 Journal Br. J. Dermatol. Section Abstract Doc Link 9767234 Disease Relevance 0.32 Pain Relevance 0.11
Northern blot analysis showed that MC1-R mRNA expression was induced 24 h after UVB irradiation in a dose-dependent manner, and that 24-h treatment with ET-1 also induced an expression of MC1-R mRNA, whereas TNF-alpha downregulated the expression.
Positive_regulation (induced) of Gene_expression (expression) of MC1-R
18) Confidence 0.49 Published 1998 Journal Br. J. Dermatol. Section Abstract Doc Link 9767234 Disease Relevance 0.33 Pain Relevance 0.11
Northern blot analysis showed that MC1-R mRNA expression was induced 24 h after UVB irradiation in a dose-dependent manner, and that 24-h treatment with ET-1 also induced an expression of MC1-R mRNA, whereas TNF-alpha downregulated the expression.
Positive_regulation (induced) of Gene_expression (expression) of MC1-R
19) Confidence 0.49 Published 1998 Journal Br. J. Dermatol. Section Abstract Doc Link 9767234 Disease Relevance 0.32 Pain Relevance 0.11
Northern blot analysis showed that MC1-R mRNA expression was induced 24 h after UVB irradiation in a dose-dependent manner, and that 24-h treatment with ET-1 also induced an expression of MC1-R mRNA, whereas TNF-alpha downregulated the expression.
Positive_regulation (induced) of Gene_expression (expression) of MC1-R
20) Confidence 0.49 Published 1998 Journal Br. J. Dermatol. Section Abstract Doc Link 9767234 Disease Relevance 0.33 Pain Relevance 0.11

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