INT65305

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Context Info
Confidence 0.22
First Reported 1996
Last Reported 2008
Negated 1
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 2.44
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MC2R) signal transducer activity (MC2R)
Anatomy Link Frequency
B16-F1 1
skin 1
melanocyte 1
MSCs 1
MC3 1
MC2R (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 4 99.96 Very High Very High Very High
Antinociceptive 1 99.46 Very High Very High Very High
Spinal cord 3 95.20 Very High Very High Very High
Neuropathic pain 3 92.24 High High
antagonist 1 87.32 High High
Pain 1 85.76 High High
withdrawal 2 82.32 Quite High
allodynia 3 78.08 Quite High
Eae 3 76.84 Quite High
melanocortin 1 receptor 6 75.00 Quite High
Disease Link Frequency Relevance Heat
Skin Cancer 14 99.60 Very High Very High Very High
Obesity 9 99.60 Very High Very High Very High
Skin Diseases 1 98.92 Very High Very High Very High
Neuropathic Pain 6 92.24 High High
Nociception 3 92.16 High High
Acne 1 89.96 High High
Carcinoma 1 84.16 Quite High
INFLAMMATION 3 78.96 Quite High
Injury 3 76.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The melanocortin (MC) receptor type-1 (MC1-R) is the only one of the five MC receptor subtypes expressed in human adipose tissue explants, human mesenchymal stem cells (MSCs), and MSC-derived adipocytes.
Gene_expression (expressed) of MC receptor in MSCs associated with obesity
1) Confidence 0.22 Published 2008 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 18946769 Disease Relevance 0.43 Pain Relevance 0.07
Our findings form a framework within which MC-1 receptor expression can be studied in various skin diseases.
Gene_expression (expression) of MC-1 receptor in skin associated with skin diseases
2) Confidence 0.20 Published 1999 Journal Exp. Dermatol. Section Abstract Doc Link 10597134 Disease Relevance 0.35 Pain Relevance 0.07
We also tested these analogues on B16-F1 mouse melanoma cells endogenously expressing the MC1 receptor for binding and for ability to increase cAMP levels as well as on COS-7 cells transfected with the human MC receptors.
Gene_expression (expressing) of MC1 receptor in B16-F1 associated with skin cancer
3) Confidence 0.07 Published 2006 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 17040213 Disease Relevance 0.18 Pain Relevance 0.07
No antinociceptive action was observed after administration of the selective MC3 receptor agonist Nle-gamma-MSH.
Gene_expression (administration) of MC3 receptor in MC3 associated with agonist and antinociceptive
4) Confidence 0.07 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 11050135 Disease Relevance 0.79 Pain Relevance 1.13
The human melanocortin-1 (MC1) receptor was stably expressed in the amelanotic mouse melanoma cell clone B16-G4F which does not express its own (mouse) MC1 receptor and hence is unresponsive to alpha melanocyte stimulating hormone (alpha MSH).
Neg (not) Gene_expression (express) of MC1 receptor in melanocyte associated with skin cancer
5) Confidence 0.04 Published 1996 Journal J. Cell. Sci. Section Abstract Doc Link 8856498 Disease Relevance 0.23 Pain Relevance 0.07
These results indicate that human MC1 receptor expressed in mouse B16-G4F cells induces constitutive activation of the signalling pathway controlling melanogenesis, most likely by tightly coupling to Gs alpha, in a similar manner to that reported for constitutively active receptor mutants in other systems.
Gene_expression (expressed) of MC1 receptor
6) Confidence 0.04 Published 1996 Journal J. Cell. Sci. Section Abstract Doc Link 8856498 Disease Relevance 0.22 Pain Relevance 0.07
From several stable transfectant cell lines expressing the human MC1 receptor in relatively high numbers, three melanin producing clones (G4F-12, 14, and 15) and one amelanotic clone (G4F-7) were further analyzed in competition binding experiments and in cAMP and melanin assays.
Spec (analyzed) Gene_expression (expressing) of MC1 receptor
7) Confidence 0.04 Published 1996 Journal J. Cell. Sci. Section Abstract Doc Link 8856498 Disease Relevance 0.24 Pain Relevance 0.07

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