INT65319

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Context Info
Confidence 0.01
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.96
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PROC) extracellular space (PROC) extracellular region (PROC)
plasma membrane (PROC)
Anatomy Link Frequency
brain 1
PROC (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 6 99.92 Very High Very High Very High
Inflammation 70 97.76 Very High Very High Very High
cINOD 7 91.68 High High
Paracetamol 5 91.24 High High
Central nervous system 2 90.36 High High
Kinase C 94 87.52 High High
aspirin 1 86.88 High High
cytokine 18 80.24 Quite High
agonist 20 60.60 Quite High
Pyramidal cell 1 34.64 Quite Low
Disease Link Frequency Relevance Heat
Shock 5 100.00 Very High Very High Very High
INFLAMMATION 80 97.76 Very High Very High Very High
Ovarian Cancer 8 94.52 High High
Fasciculation 13 93.04 High High
Stress 3 91.88 High High
Apoptosis 8 89.32 High High
Cancer 38 89.16 High High
Colon Cancer 3 87.92 High High
Disease 2 85.12 High High
Adhesions 20 72.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In agreement with a previous study [14], PC mRNA was widely expressed in the developing brain from E12 to adult stages (Fig. 1a and Fig.
Transcription (expressed) of PC in brain
1) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2919383 Disease Relevance 0.30 Pain Relevance 0
Besides the transcription factors c-myc and Bcl-2, which were obvious candidates for the potential link between Receptor Ck and hTERT expression, we also examined cyclin D and peroxisome proliferator-activated receptor ?
Transcription (transcription) of factors
2) Confidence 0.01 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.46 Pain Relevance 0.05
A2AR engagement, PGE2 or cAMP-elevating agents each increased mRNA expression of immunomodulatory transcription factors NR4A3, ATF3, TNFAIP3 and IER2, of the enzyme COX-2, of dual-specificity phosphatases 1 and 2 and of the regulatory element SOCS3.
Transcription (expression) of factors
3) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2654409 Disease Relevance 0.49 Pain Relevance 0.31
The transcriptional regulation of heat shock genes: a plethora of heat shock factors and regulatory conditions.
Transcription (transcriptional) of factors associated with shock
4) Confidence 0.01 Published 1996 Journal EXS Section Title Doc Link 8856973 Disease Relevance 0.75 Pain Relevance 0.09
Based on the results of our experiments, we have proposed a signaling pathway (Figure 11) that links Receptor Ck with hTERT gene transcription through the transcription factors, c-myc and PPAR?.
Transcription (transcription) of factors
5) Confidence 0.00 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0.28
It is proposed that the major mechanism by these anti-inflammatory agents is a shared pathway dependent on the suppression of NF-kappaB activity, which may subsequently decrease transcription of growth factors, chemokines and proteases such as COX-2, VEGF, IL-8/CXCL8, MCP-1/CCL-2, MIP1alpha/CCL-3, tPA and uPA, which are shown to be elevated in ovarian carcinoma, and which play diverse roles such as inducing angiogenesis, invasion, autocrine growth loops and resistance to apoptosis.
Transcription (transcription) of factors associated with chemokine, inflammation, ovarian cancer and apoptosis
6) Confidence 0.00 Published 2004 Journal Neoplasma Section Abstract Doc Link 15254653 Disease Relevance 0.97 Pain Relevance 0.71

General Comments

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