INT65324

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Context Info
Confidence 0.66
First Reported 1996
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 12
Total Number 15
Disease Relevance 7.97
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Tnni3)
Anatomy Link Frequency
plasma 1
blood 1
skeletal muscle 1
heart 1
Tnni3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 9 99.74 Very High Very High Very High
Angina 16 99.00 Very High Very High Very High
imagery 13 96.28 Very High Very High Very High
ischemia 19 94.36 High High
Inflammation 2 84.16 Quite High
Pain 4 71.32 Quite High
adenocard 4 50.56 Quite High
addiction 9 46.88 Quite Low
agonist 3 12.84 Low Low
lidocaine 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 144 100.00 Very High Very High Very High
Ventricular Remodeling 132 99.36 Very High Very High Very High
Angina 9 99.00 Very High Very High Very High
Natriuresis 5 98.88 Very High Very High Very High
Urological Neuroanatomy 2 98.62 Very High Very High Very High
Hypertension 23 96.72 Very High Very High Very High
Infarction 27 96.08 Very High Very High Very High
Diabetes Mellitus 5 96.04 Very High Very High Very High
Coronary Artery Disease 11 95.32 Very High Very High Very High
Coronary Heart Disease 12 94.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevated cardiac troponin I levels were found to be related to the extent of myocardial involvement, but did not necessarily indicate poor prognosis in children with myocarditis.
Gene_expression (levels) of cardiac troponin I associated with coronary heart disease
1) Confidence 0.66 Published 2009 Journal J. Pediatr. Section Abstract Doc Link 19324224 Disease Relevance 0.52 Pain Relevance 0.14
Cardiac troponin I was undetectable (< 0.5 microgram/l) in sera from healthy subjects (n = 46), patients with severe skeletal muscle damage (n = 8), and all but 1 patient with chronic renal failure (n = 39).
Gene_expression (undetectable) of Cardiac troponin I in skeletal muscle associated with chronic renal failure
2) Confidence 0.62 Published 1997 Journal Int. J. Clin. Lab. Res. Section Abstract Doc Link 9144029 Disease Relevance 0.24 Pain Relevance 0.06
Addition of Isoprenaline to the electrically paced (5 Hz) heart caused marked elevations of the cMyBP-C and cTnI phosphorylation levels, but did not result in a further significant increase in MLC-2 phosphorylation.
Gene_expression (levels) of cTnI in heart
3) Confidence 0.52 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0.03
The overall correlation between the endogenous cTnI and cMyBP-C phosphorylation levels (Fig. 7) turned out to be positive and highly significant.
Gene_expression (levels) of cTnI
4) Confidence 0.52 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0
These experiments indicate that the PKA-sensitive phosphorylation sites on cMyBP-C and/or cTnI were not saturated under basal conditions even in the Isoprenaline group.
Gene_expression (/) of cTnI
5) Confidence 0.45 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0.16 Pain Relevance 0
METHODS: In a multicenter study, blood specimens from 1404 symptomatic patients were analyzed for cardiac troponin I, a serum marker not detected in the blood of healthy persons.
Neg (not) Gene_expression (detected) of cardiac troponin I in blood
6) Confidence 0.25 Published 1996 Journal N. Engl. J. Med. Section Body Doc Link 8857017 Disease Relevance 0.19 Pain Relevance 0
A 12-lead electrocardiogram (Marquette Mac 5K) and BSM (PRIME-ECG) were recorded at initial presentation, and cardiac troponin I and/or creatine kinase-MB levels measured at 12 hours after symptom onset.
Gene_expression (levels) of cardiac troponin I
7) Confidence 0.23 Published 2003 Journal Am. J. Cardiol. Section Abstract Doc Link 12888126 Disease Relevance 0.74 Pain Relevance 0.09
Serum proteins (creatine kinase metabolite and cardiac troponin I) were measured before and 8 and 18 h after surgery.
Gene_expression (measured) of cardiac troponin I
8) Confidence 0.07 Published 2001 Journal Br J Anaesth Section Abstract Doc Link 11878685 Disease Relevance 0.33 Pain Relevance 0.07
The peak CK-MB and TnI levels were significantly higher in the LVR group than the group without LVR.
Gene_expression (levels) of TnI associated with ventricular remodeling
9) Confidence 0.07 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2771835 Disease Relevance 1.13 Pain Relevance 0
The TnI level was 70.2±73.3 ng/mL in the LVR group and 43.2±39.5 ng/mL in the group without LVR (p=0.024).
Gene_expression (level) of TnI associated with ventricular remodeling
10) Confidence 0.07 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2771835 Disease Relevance 1.12 Pain Relevance 0
RESULTS: Cardiac TnI levels > or = 0.2 ng/ml (odds ratio [OR] 1.93, 95% confidence interval [CI] 1.09-3.40) and MLC-1 levels > or = 1 ng/ml (OR 3.24, 95% CI 1.83-5.73) were both significant predictors of death or MI during long-term follow-up; MLC-1 was, however, the only independent biochemical predictor (OR 2.11,95% CI 1.14-3.93).
Gene_expression (levels) of TnI
11) Confidence 0.06 Published 2003 Journal Clin Cardiol Section Body Doc Link 12685622 Disease Relevance 0.07 Pain Relevance 0
Among various laboratory data, the peak levels of creatine kinase MB (CK-MB), TnI, and N-terminal pro b-type natriuretic peptide (NT-pro-BNP) were evaluated for estimation of the infarction burden.
Gene_expression (levels) of TnI associated with natriuresis and infarction
12) Confidence 0.06 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2771835 Disease Relevance 0.97 Pain Relevance 0.07
The levels of CK-MB, TnI and BNP were significantly higher in the incomplete STR group (p<0.002, p<0.001 and p<0.043, respectively).
Gene_expression (levels) of TnI
13) Confidence 0.06 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2771846 Disease Relevance 0.79 Pain Relevance 0.20
The specificities of the markers in patients with and without cocaine use were as follows: cardiac troponin I, 94% vs 94%, (p = 1.0); CK-MB, 75% vs 88% (p = 0.24); and myoglobin, 50% vs 82%, (p = 0.02), respectively.
Gene_expression (follows) of cardiac troponin I associated with cocaine
14) Confidence 0.05 Published 1998 Journal Am. Heart J. Section Abstract Doc Link 9489972 Disease Relevance 0.80 Pain Relevance 0.45
To study their association with AMI and their value in diagnosis of AMI, white blood cell (WBC) count, plasma MPO, plasma 3-Cl-Tyr, and conventional risk factors such as cardiac troponin I and CK-MB were examined in AMI patients during the onset of chest pain.
Spec (examined) Gene_expression (examined) of cardiac troponin I in plasma associated with angina, urological neuroanatomy and myocardial infarction
15) Confidence 0.04 Published 2008 Journal Clin. Biochem. Section Abstract Doc Link 18314009 Disease Relevance 0.91 Pain Relevance 0.14

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