INT6533

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Context Info
Confidence 0.34
First Reported 1989
Last Reported 1992
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.45

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peptidase activity (Ctsl1) extracellular region (Ctsl1) histone binding (Ctsl1)
vacuole (Ctsl1) lysosome (Ctsl1) cytoplasm (Ctsl1)
Anatomy Link Frequency
brain 2
Ctsl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 1 99.44 Very High Very High Very High
Opioid 2 96.04 Very High Very High Very High
Enkephalin 6 79.44 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analogs were prepared by solid-phase syntheses and evaluated for inhibition of rat brain cathepsin L (E.C. 3.4.22.15) and papain (E.C.3.4.22.2), or binding to rat brain opioid receptors using tritiated DSLET (delta), DAGO (mu) and U69593 (kappa) in competitive binding assays.
cathepsin L Binding (binding) of in brain associated with opioid receptor
1) Confidence 0.34 Published 1992 Journal Pept. Res. Section Abstract Doc Link 1330108 Disease Relevance 0 Pain Relevance 0.30
The synthetic substrate provided rapid and sensitive assays for the brain cathepsin L and its interaction with 13-14 kDa (cerebrocystatin) and 70 kDa (T-kininogen) rat brain inhibitors.
cathepsin L Binding (interaction) of in brain
2) Confidence 0.29 Published 1989 Journal Peptides Section Abstract Doc Link 2787909 Disease Relevance 0 Pain Relevance 0.15

General Comments

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