INT6534

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Context Info
Confidence 0.54
First Reported 1989
Last Reported 1992
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.11
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsl1) extracellular region (Ctsl1) histone binding (Ctsl1)
vacuole (Ctsl1) lysosome (Ctsl1) cytoplasm (Ctsl1)
Anatomy Link Frequency
brain 2
Ctsl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 9 99.44 Very High Very High Very High
anesthesia 1 98.32 Very High Very High Very High
opioid receptor 1 97.24 Very High Very High Very High
Opioid 2 97.00 Very High Very High Very High
Transcranial magnetic stimulation 2 75.52 Quite High
depression 1 56.48 Quite High
Disease Link Frequency Relevance Heat
Depression 1 56.48 Quite High
Convulsion 1 50.72 Quite High
Congenital Anomalies 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analogs were prepared by solid-phase syntheses and evaluated for inhibition of rat brain cathepsin L (E.C. 3.4.22.15) and papain (E.C.3.4.22.2), or binding to rat brain opioid receptors using tritiated DSLET (delta), DAGO (mu) and U69593 (kappa) in competitive binding assays.
Negative_regulation (inhibition) of cathepsin L in brain associated with opioid receptor
1) Confidence 0.54 Published 1992 Journal Pept. Res. Section Abstract Doc Link 1330108 Disease Relevance 0 Pain Relevance 0.30
The suppression of cathepsin L- or papain-mediated hydrolysis of substrates by inhibitors may be the result of competition between their binding domains at the enzyme catalytic center.
Negative_regulation (suppression) of cathepsin L
2) Confidence 0.53 Published 1989 Journal Peptides Section Abstract Doc Link 2787909 Disease Relevance 0 Pain Relevance 0.15
Enkephalin analogs as substrates for the assay of brain cysteine proteinase (Cathepsin L) and its endogenous inhibitors.
Negative_regulation (inhibitors) of Cathepsin L in brain associated with enkephalin
3) Confidence 0.39 Published 1989 Journal Peptides Section Title Doc Link 2787909 Disease Relevance 0 Pain Relevance 0.30
The coil demography was altered and the MEP scalp topography was moderately reduced by ET injections.
Negative_regulation (reduced) of MEP
4) Confidence 0.04 Published 1990 Journal Neurosurgery Section Abstract Doc Link 2133376 Disease Relevance 0.11 Pain Relevance 0.20

General Comments

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