INT65390

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Context Info
Confidence 0.70
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 30
Total Number 57
Disease Relevance 23.31
Pain Relevance 9.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plat) extracellular space (Plat) extracellular region (Plat)
cytoplasm (Plat)
Anatomy Link Frequency
astrocytes 20
nucleus accumbens 6
brains 3
neurite 2
MSCs 1
Plat (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 376 100.00 Very High Very High Very High
Nucleus accumbens 39 100.00 Very High Very High Very High
Kinase C 2 100.00 Very High Very High Very High
Nicotine 11 99.98 Very High Very High Very High
Multiple sclerosis 21 99.78 Very High Very High Very High
ischemia 140 99.72 Very High Very High Very High
Inflammatory response 10 99.24 Very High Very High Very High
Spinal cord 28 98.68 Very High Very High Very High
narcan 13 98.64 Very High Very High Very High
Clonidine 2 98.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Atherosclerosis 44 99.92 Very High Very High Very High
Coronary Artery Disease 12 99.92 Very High Very High Very High
Middle Cerebral Artery Infarction 476 99.78 Very High Very High Very High
Demyelinating Disease 27 99.78 Very High Very High Very High
Cv Unclassified Under Development 112 99.72 Very High Very High Very High
Pressure And Volume Under Development 85 99.56 Very High Very High Very High
Carotid Stenosis 21 99.44 Very High Very High Very High
Myocardial Infarction 7 99.30 Very High Very High Very High
INFLAMMATION 147 99.24 Very High Very High Very High
Sepsis 32 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A DNA microarray screening revealed that the expression levels of tissue plasminogen activator (tPA) mRNA in the nucleus accumbens of morphine- or methamphetamine-dependent rats were significantly increased compared with those in control animals.
Positive_regulation (increased) of tissue plasminogen activator in nucleus accumbens associated with nucleus accumbens and morphine
1) Confidence 0.70 Published 2005 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15684570 Disease Relevance 0.26 Pain Relevance 0.56
A DNA microarray screening revealed that the expression levels of tissue plasminogen activator (tPA) mRNA in the nucleus accumbens of morphine- or methamphetamine-dependent rats were significantly increased compared with those in control animals.
Positive_regulation (increased) of tPA in nucleus accumbens associated with nucleus accumbens and morphine
2) Confidence 0.70 Published 2005 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15684570 Disease Relevance 0.26 Pain Relevance 0.56
In the brains of MS patients, tissue plasminogen activator (tPA) mRNA and protein are upregulated, and changes in the levels of tPA correlate with progression of the disease.
Positive_regulation (upregulated) of tPA in brains associated with multiple sclerosis and disease
3) Confidence 0.70 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12486171 Disease Relevance 1.15 Pain Relevance 0.32
In the brains of MS patients, tissue plasminogen activator (tPA) mRNA and protein are upregulated, and changes in the levels of tPA correlate with progression of the disease.
Positive_regulation (upregulated) of tissue plasminogen activator in brains associated with multiple sclerosis and disease
4) Confidence 0.70 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12486171 Disease Relevance 1.16 Pain Relevance 0.32
A single morphine treatment induced tPA mRNA and protein expression in a naloxone-sensitive manner, which was associated with an increase in the enzyme activity in the nucleus accumbens (NAc).
Positive_regulation (induced) of tPA in NAc associated with nucleus accumbens, narcan and morphine
5) Confidence 0.68 Published 2006 Journal Nihon Arukoru Yakubutsu Igakkai Zasshi Section Abstract Doc Link 16619846 Disease Relevance 0.07 Pain Relevance 0.80
Fig. 5b shows that MSC treatment significantly increased the tPA mRNA level and concomitantly decreased the PAI-1 mRNA level.
Positive_regulation (increased) of tPA mRNA
6) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.68 Pain Relevance 0
This enhanced tPA activity may increase active neurotrophins [48]–[50], [86].
Spec (may) Positive_regulation (increase) of tPA
7) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.44 Pain Relevance 0.07
We do not exclude a contribution from other parenchymal cells to the MSC enhanced tPA activity; however, the high concentration of astrocytes in the IBZ and the predominance of numbers astrocytes in parenchymal tissue, suggest that the astrocyte is a robust contributor to the MSC mediated tPA activity and subsequent functional recovery.
Positive_regulation (enhanced) of tPA in astrocytes
8) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.31 Pain Relevance 0
This enhanced tPA activity may increase active neurotrophins [48]–[50], [86].
Positive_regulation (enhanced) of tPA
9) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.39 Pain Relevance 0.07
In OGD astrocytes, MSC co-culture increased the tPA concentration to 2.24±0.08 ng/mL compared to OGD astrocytes without MSC co-culture (2.14±0.14 ng/mL). tPA concentrations were significantly increased in OGD astrocytes with or without MSC co-culture compared with normal cultured astrocytes (p<0.01), respectively.
Positive_regulation (increased) of tPA in astrocytes
10) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0 Pain Relevance 0
We do not exclude a contribution from other parenchymal cells to the MSC enhanced tPA activity; however, the high concentration of astrocytes in the IBZ and the predominance of numbers astrocytes in parenchymal tissue, suggest that the astrocyte is a robust contributor to the MSC mediated tPA activity and subsequent functional recovery.
Positive_regulation (mediated) of tPA in astrocyte
11) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.18 Pain Relevance 0
In vivo, treatment of MCAo with MSCs increased tPA activity, and this increase likely contributed to the observed neurite outgrowth and synaptic plasticity.
Positive_regulation (increased) of tPA in neurite associated with middle cerebral artery infarction
12) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.78 Pain Relevance 0.07
Normal cultured astrocytes secreted tPA at a concentration of 1.27±0.02 ng/mL, and normal astrocytes co-cultured with MSCs significantly (p<0.05) increased the tPA concentration to 1.32±0.01 ng/mL.
Positive_regulation (increased) of tPA in astrocytes
13) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0 Pain Relevance 0
MSCs reduce PAI-1 in reactive astrocytes, which thereby increase tPA activity.
Positive_regulation (increase) of tPA in astrocytes
14) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.39 Pain Relevance 0.07
Morphine significantly but transiently increased extracellular tPA activity in the NAc, which was completely blocked by naloxone.
Positive_regulation (increased) of tPA in NAc associated with nucleus accumbens, narcan and morphine
15) Confidence 0.66 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17286591 Disease Relevance 0 Pain Relevance 1.38
Nicotine increased tPA protein levels and promoted the release of tPA into the extracellular space in the NAc.
Positive_regulation (increased) of tPA in NAc associated with nucleus accumbens and nicotine
16) Confidence 0.62 Published 2008 Journal Nihon Arukoru Yakubutsu Igakkai Zasshi Section Abstract Doc Link 18646640 Disease Relevance 0.17 Pain Relevance 1.05
Morphine upregulation of Plat mRNA was linked to drug-related reward properties [21], whereas the inhibition of Fkbp5 was found to prevent symptoms of opioid withdrawal syndrome [22].
Positive_regulation (upregulation) of Plat associated with withdrawal, opioid and morphine
17) Confidence 0.52 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.38 Pain Relevance 0.66
In this study, we establish that tPA activity increases during major oligodendrocyte glycoprotein-induced experimental allergic encephalomyelitis (EAE) in normal mice.
Positive_regulation (increases) of tPA in oligodendrocyte associated with multiple sclerosis and experimental autoimmune encephalomyelitis
18) Confidence 0.50 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12486171 Disease Relevance 1.36 Pain Relevance 0.43
In addition, repeated METH treatment increased tPA activity in the nucleus accumbens.
Positive_regulation (increased) of tPA in nucleus accumbens associated with nucleus accumbens
19) Confidence 0.50 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15659235 Disease Relevance 0.08 Pain Relevance 0.46
The concomitant MSC induced reduction of PAI-1 and increase of tPA in astrocytes of the IBZ thereby amplify tPA activity which contributes to neurite outgrowth.
Positive_regulation (increase) of tPA in astrocytes
20) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.78 Pain Relevance 0.15

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