INT65391

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Context Info
Confidence 0.32
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 16
Disease Relevance 5.71
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Vsig2) biological_process (Vsig2)
Anatomy Link Frequency
articular 2
faces 2
cartilage 1
Neuro-2a 1
Vsig2 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 327 99.64 Very High Very High Very High
withdrawal 6 91.28 High High
Clonidine 2 82.04 Quite High
Kinase C 1 75.12 Quite High
Arthritis 12 74.00 Quite High
sodium channel 76 73.96 Quite High
Pain 5 73.12 Quite High
agonist 5 70.32 Quite High
anesthesia 12 5.00 Very Low Very Low Very Low
Versed 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Vibrio Infection 1 99.84 Very High Very High Very High
Osteoarthritis 309 99.64 Very High Very High Very High
Osteophyte 130 99.34 Very High Very High Very High
Endometriosis (extended) 48 99.24 Very High Very High Very High
Glioma 4 98.00 Very High Very High Very High
Neuroblastoma 12 97.82 Very High Very High Very High
Sprains And Strains 48 96.54 Very High Very High Very High
Knee Osteoarthritis 18 94.20 High High
Hypercalcemia 42 93.28 High High
Body Weight 104 85.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
According to these authors, this additional purification step enhanced recovery of P-CTX-1 to 76% vs. 63% with the standard purification protocol.
Positive_regulation (enhanced) of CTX-1
1) Confidence 0.32 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.12 Pain Relevance 0
This study stressed the importance of the A-ring side chain of CTX-1B for triggering adequate the mouse immune response.
Positive_regulation (importance) of CTX-1B
2) Confidence 0.32 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.06 Pain Relevance 0
Some cell strains, such as the human embryonic HEK cell line or the neuroblastoma x glioma hybrid NG108-15 cell line, have been used for studying CTX’s modes of action or for studying their suitability for CTX determination by using the same approach as the one used with Neuro-2a cells (O/V dependent CBA) [106,188–191].
Positive_regulation (suitability) of CTX in Neuro-2a associated with neuroblastoma, sprains and strains and glioma
3) Confidence 0.28 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.29 Pain Relevance 0.04
1 of equivalent CTX per mg of extract (corresponding to 5 × 10?
Positive_regulation (equivalent) of CTX
4) Confidence 0.28 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.07 Pain Relevance 0
Moreover, the stimulatory effect of forskolin and cholera toxin (CTX) (activator of G (s)-proteins) on the secretion of insulin was markedly enhanced in the presence of emiglitate.
Positive_regulation (enhanced) of CTX associated with vibrio infection
5) Confidence 0.22 Published 1996 Journal Biosci. Rep. Section Abstract Doc Link 8861537 Disease Relevance 0.16 Pain Relevance 0.23
Contrary to our initial hypothesis that CTX-II levels should decrease after intra-articular hyaluronic acid injections, we found a significant increase in urinary CTX-II levels that was sustained throughout the study.
Positive_regulation (increase) of CTX-II in articular
6) Confidence 0.09 Published 2010 Journal Clin. Rheumatol. Section Abstract Doc Link 20101426 Disease Relevance 0.39 Pain Relevance 0.24
This increase in CTX-II was sustained throughout the entire 6 months follow-up period (repeated measures ANOVA, p < 0.015).
Positive_regulation (increase) of CTX-II
7) Confidence 0.09 Published 2010 Journal Clin. Rheumatol. Section Abstract Doc Link 20101426 Disease Relevance 0.54 Pain Relevance 0.30
There was a statistically significant increase (p = 0.0136) in CTX-II a week after the third intra-articular injection of hyaluronic acid (6,216 ng/mmol +/- 4,428) compared with baseline (2,233 ng/mmol +/- 1,220).
Positive_regulation (increase) of CTX-II in articular
8) Confidence 0.05 Published 2010 Journal Clin. Rheumatol. Section Abstract Doc Link 20101426 Disease Relevance 0.54 Pain Relevance 0.31
It shows that when CMC joint faces affected by OST are measured alone they indicate the likelihood of joint faces affected by JSN, which in turn is predictive of increased levels of uCTX2.
Positive_regulation (increased) of uCTX2 in faces associated with osteophyte
9) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840035 Disease Relevance 0.88 Pain Relevance 0
One example of the potential complex interrelationship of OST and JSN was demonstrated by the increase of uCTX2 with increasing number of CMC joint faces affected by JSN.
Positive_regulation (increase) of uCTX2 in faces associated with osteophyte
10) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840035 Disease Relevance 0.80 Pain Relevance 0.03
The initial increases in the levels of the marker observed immediately after ovariectomy corresponded well with the increase in CTX-II levels observed at the menopause in humans, where a 100% increase has been demonstrated [18].
Positive_regulation (increase) of CTX-II associated with endometriosis (extended)
11) Confidence 0.01 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400436 Disease Relevance 0.27 Pain Relevance 0.04
CTX-II levels are increased twofold after the menopause, and supplemental hormone replacement therapy can suppress this marker to premenopausal levels, further supporting a role of estrogen as a regulator of cartilage metabolism [18].
Positive_regulation (increased) of CTX-II in cartilage associated with endometriosis (extended)
12) Confidence 0.01 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400436 Disease Relevance 0.52 Pain Relevance 0.16
Rats in the highest quartile (showing the largest increases in CTX-II levels) included 11 of the 12 rats from the vehicle-treated OVX group, and these animals showed significantly more surface erosion than rats in the lower quartiles.
Positive_regulation (increases) of CTX-II
13) Confidence 0.01 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400436 Disease Relevance 0.13 Pain Relevance 0
In contrast, the lower dose of SERM was only partly effective in reducing the elevated CTX-II levels.
Positive_regulation (elevated) of CTX-II
14) Confidence 0.01 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400436 Disease Relevance 0.37 Pain Relevance 0.04
Ovariectomy also significant increased CTX-I and CTX-II.
Positive_regulation (increased) of CTX-II
15) Confidence 0.01 Published 2004 Journal Arthritis Res Ther Section Abstract Doc Link PMC400436 Disease Relevance 0.23 Pain Relevance 0.07
The difference was most pronounced in the first 4 to 6 weeks after ovariectomy, where CTX-II levels were increased by 100%, but at later time points the difference between the OVX and sham-operated animals were diminished.
Positive_regulation (increased) of CTX-II
16) Confidence 0.01 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400436 Disease Relevance 0.35 Pain Relevance 0.05

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