INT654

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Context Info
Confidence 0.81
First Reported 1975
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 250
Total Number 252
Disease Relevance 75.12
Pain Relevance 47.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (REN) extracellular space (REN) extracellular region (REN)
intracellular (REN) response to stress (REN)
Anatomy Link Frequency
blood 28
plasma 20
kidney 12
renal nerve 9
sympathetic 9
REN (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 147 100.00 Very High Very High Very High
agonist 99 100.00 Very High Very High Very High
anesthesia 97 100.00 Very High Very High Very High
Catecholamine 61 100.00 Very High Very High Very High
Calcium channel 43 100.00 Very High Very High Very High
corticosteroid 8 100.00 Very High Very High Very High
adenocard 151 99.92 Very High Very High Very High
Clonidine 126 99.92 Very High Very High Very High
Dopamine 38 99.92 Very High Very High Very High
tolerance 31 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 204 100.00 Very High Very High Very High
Cv Unclassified Under Development 116 100.00 Very High Very High Very High
Natriuresis 97 100.00 Very High Very High Very High
Renal Artery Obstruction 79 100.00 Very High Very High Very High
Pancreatitis 12 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 235 99.96 Very High Very High Very High
Renal Failure 51 99.96 Very High Very High Very High
Cancer 50 99.96 Very High Very High Very High
Renal Cancer 6 99.96 Very High Very High Very High
Brain Injury 2 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sodium nitroprusside increased renin secretion, which was not seen with adenosine.
Localization (secretion) of renin associated with adenocard
1) Confidence 0.81 Published 1990 Journal Anesth. Analg. Section Abstract Doc Link 2240636 Disease Relevance 0.50 Pain Relevance 0.30
However, in animals adenosine by intrarenal infusion decreases renal blood flow (RBF), glomerular filtration rate (GFR), urine flow, and causes an inhibition of renin secretion.
Localization (secretion) of renin in urine associated with adenocard
2) Confidence 0.81 Published 1990 Journal Anesth. Analg. Section Abstract Doc Link 2240636 Disease Relevance 0.59 Pain Relevance 0.30
Evidence for a role of dopamine and endogenous opioids in the control of the secretion of renin and adrenal steroids was sought in man.
Localization (secretion) of renin associated with dopamine and endogenous opioid
3) Confidence 0.81 Published 1981 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 7030527 Disease Relevance 0 Pain Relevance 0.38
CONCLUSION: Our results indicate a key role of renal sympathetic fibers in mediating renin release during hypotension in humans, and that epidural anesthesia interferes with the functional integrity of the renin-angiotensin system.


Localization (release) of renin in sympathetic
4) Confidence 0.80 Published 1994 Journal Anesthesiology Section Body Doc Link 8017664 Disease Relevance 0 Pain Relevance 0
Sympathetic neural blockade by thoracic epidural anesthesia suppresses renin release in response to arterial hypotension.
Localization (release) of renin in neural associated with pressure volume 2 under development and thoracic epidural anesthesia
5) Confidence 0.80 Published 1994 Journal Anesthesiology Section Title Doc Link 8017664 Disease Relevance 0.10 Pain Relevance 0.19
To assess the relative contributions of neural and nonneural stimuli of renin secretion, the effects of an alpha 1-agonist, phenylephrine (Phe), or a beta-agonist, epinephrine (Epi), on plasma renin activity (PRA), renal blood flow (RBF), and glomerular filtration rate (GFR) were compared during sympathetic blockade with epidural hypotensive anesthesia [mean arterial blood pressure (MAP) = 60 and 50 mmHg].
Localization (secretion) of renin in sympathetic associated with anesthesia, hypotension, epidural and agonist
6) Confidence 0.80 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8238548 Disease Relevance 0.22 Pain Relevance 0.23
Adrenergic regulation of renin secretion and renal hemodynamics during deliberate hypotension in humans.
Localization (secretion) of renin associated with hypotension
7) Confidence 0.80 Published 1993 Journal Am. J. Physiol. Section Title Doc Link 8238548 Disease Relevance 0.25 Pain Relevance 0.31
K-351 (0.3 mg/kg, i.v.) significantly decreased systemic blood pressure, heart rate, mesenteric blood flow, and renin secretion rate without change in renal blood flow.
Localization (secretion) of renin in blood
8) Confidence 0.79 Published 1984 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 6149735 Disease Relevance 0.17 Pain Relevance 0
These results suggest that 1) norepinephrine released from nerve terminals may regulate active renin secretion early during development; 2) the effect of veratridine on active renin secretion was similar in fetal, newborn, and adult sheep; 3) veratridine had no significant effect on inactive renin secretion; and 4) active renin secretion due to depolarization of nerve terminals in fetal sheep is dependent on activation of beta-adrenoceptors as it is in adults.
Localization (secretion) of renin in nerve
9) Confidence 0.79 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2679151 Disease Relevance 0 Pain Relevance 0.17
Effect of dopamine on renin secretion in the anesthetized dog.
Localization (secretion) of renin associated with anesthesia and dopamine
10) Confidence 0.79 Published 1975 Journal Eur. J. Pharmacol. Section Title Doc Link 1175682 Disease Relevance 0.24 Pain Relevance 0.31
(b) Propranolol (intrarenal perfusion of 1 mg/kg in 15 min, then of 4 mg/kg/hr) alters neither the renal vasodilation nor the renin hypersecretion induced by dopamine.
Localization (hypersecretion) of renin associated with dopamine and increased venous pressure under development
11) Confidence 0.79 Published 1975 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1175682 Disease Relevance 0.28 Pain Relevance 0.22
These results suggest that 1) norepinephrine released from nerve terminals may regulate active renin secretion early during development; 2) the effect of veratridine on active renin secretion was similar in fetal, newborn, and adult sheep; 3) veratridine had no significant effect on inactive renin secretion; and 4) active renin secretion due to depolarization of nerve terminals in fetal sheep is dependent on activation of beta-adrenoceptors as it is in adults.
Localization (secretion) of renin in nerve
12) Confidence 0.79 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2679151 Disease Relevance 0 Pain Relevance 0.16
Suppression of renin release by antagonism of endogenous opiates in the dog.
Localization (release) of renin associated with narcan and opiate
13) Confidence 0.79 Published 1986 Journal Am. J. Physiol. Section Title Doc Link 3515972 Disease Relevance 0.06 Pain Relevance 0.73
The influence of blockade of endogenous opioids on the release of renin due to partial renal arterial constriction was determined acutely and chronically in unilaterally nephrectomized dogs.
Localization (release) of renin associated with endogenous opioid
14) Confidence 0.79 Published 1986 Journal Am. J. Physiol. Section Abstract Doc Link 3515972 Disease Relevance 0 Pain Relevance 0.50
These results suggest that 1) norepinephrine released from nerve terminals may regulate active renin secretion early during development; 2) the effect of veratridine on active renin secretion was similar in fetal, newborn, and adult sheep; 3) veratridine had no significant effect on inactive renin secretion; and 4) active renin secretion due to depolarization of nerve terminals in fetal sheep is dependent on activation of beta-adrenoceptors as it is in adults.
Localization (secretion) of renin in nerve
15) Confidence 0.79 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2679151 Disease Relevance 0 Pain Relevance 0.18
Veratridine (10-300 microM) significantly increased active renin secretion and produced a small but nonsignificant rise in inactive renin secretion in all three groups of animals (P less than 0.05).
Localization (secretion) of renin
16) Confidence 0.79 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2679151 Disease Relevance 0 Pain Relevance 0.15
Unilateral renal arterial infusion of sodium thiopental on renal function and renin secretion were investigated in unanesthetized rabbits.
Localization (secretion) of renin
17) Confidence 0.79 Published 1987 Journal Ren Physiol Section Abstract Doc Link 3331472 Disease Relevance 0 Pain Relevance 0.05
Unilateral renal arterial infusion of sodium thiopental decreased the renin secretion rate and plasma norepinephrine concentration in renal vein, whereas an anesthetic dose of sodium thiopental administered intravenously increased the renin secretion rate.
Localization (secretion) of renin in renal vein
18) Confidence 0.79 Published 1987 Journal Ren Physiol Section Abstract Doc Link 3331472 Disease Relevance 0.08 Pain Relevance 0.09
Veratridine-stimulated (300 microM) active renin secretion was antagonized by tetrodotoxin (0.5 and 5.0 microM) and DL-propranolol (1 microM) in fetal renal cortical slices.
Localization (secretion) of renin associated with tetrodotoxin
19) Confidence 0.79 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2679151 Disease Relevance 0 Pain Relevance 0.19
Unilateral renal arterial infusion of sodium thiopental decreased the renin secretion rate and plasma norepinephrine concentration in renal vein, whereas an anesthetic dose of sodium thiopental administered intravenously increased the renin secretion rate.
Localization (secretion) of renin in renal vein
20) Confidence 0.79 Published 1987 Journal Ren Physiol Section Abstract Doc Link 3331472 Disease Relevance 0.10 Pain Relevance 0.09

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