INT65424

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.01
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP1A2) oxidoreductase activity (CYP1A2) endoplasmic reticulum (CYP1A2)
enzyme binding (CYP1A2)
Anatomy Link Frequency
liver 4
CYP1A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 31 98.80 Very High Very High Very High
Inflammation 1 92.36 High High
tolerance 1 52.48 Quite High
Dextromethorphan 1 37.84 Quite Low
Nicotine 3 32.40 Quite Low
addiction 3 21.04 Low Low
fluoxetine 3 18.24 Low Low
antagonist 14 5.00 Very Low Very Low Very Low
Dopamine 14 5.00 Very Low Very Low Very Low
alcohol 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 10 99.84 Very High Very High Very High
Lung Cancer 1 99.76 Very High Very High Very High
Toxicity 3 99.40 Very High Very High Very High
Aneuploidy 2 98.00 Very High Very High Very High
INFLAMMATION 2 92.36 High High
Overdose 2 86.64 High High
Schizophrenia 37 86.08 High High
Hypoxia 3 81.80 Quite High
Ovarian Cancer 7 79.20 Quite High
Colon Cancer 17 76.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The spindle disturbing effect was only slightly enhanced by expression of CYP1A2, suggesting that metabolic activation plays only a minor role in this genotoxic effect.
Positive_regulation (enhanced) of Gene_expression (expression) of CYP1A2
1) Confidence 0.70 Published 1996 Journal Pharmacol. Toxicol. Section Abstract Doc Link 8861779 Disease Relevance 0.16 Pain Relevance 0.70
Incubation of cells transfected with human CYP1A2 (H1A2 MZ cells) with 4-20 mM acetaminophen for 6 hours at 37 degrees C caused extensive cytotoxicity (cell viability <10%).
Positive_regulation (transfected) of Gene_expression (transfected) of CYP1A2 associated with paracetamol
2) Confidence 0.50 Published 2000 Journal Cancer Gene Ther. Section Abstract Doc Link 10811468 Disease Relevance 0 Pain Relevance 0.41
Spindle disturbing effects in terms of c-mitosis and cytotoxicity of paracetamol were investigated in two Chinese hamster V79 cell lines, one of which (V79MZh1A2) was transfected with human CYP1A2.
Positive_regulation (transfected) of Gene_expression (transfected) of CYP1A2 associated with paracetamol
3) Confidence 0.50 Published 1996 Journal Pharmacol. Toxicol. Section Abstract Doc Link 8861779 Disease Relevance 0.09 Pain Relevance 0.40
Transfection of H1A2 MZ cells with human CYP1A2 sensitized them to treatment with acetaminophen, with the generation of a substantial bystander effect (complete killing of V79 cells in a mixture containing 5% transduced H1A2 MZ cells) [95].
Positive_regulation (Transfection) of Gene_expression (Transfection) of CYP1A2 associated with paracetamol
4) Confidence 0.26 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179761 Disease Relevance 0.85 Pain Relevance 0.40
CYP1A2 is expressed mainly in the liver and is induced by cigarette smoking [9].
Positive_regulation (induced) of Gene_expression (expressed) of CYP1A2 in liver associated with nicotine addiction
5) Confidence 0.26 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2584094 Disease Relevance 0.44 Pain Relevance 0.10
This suggests it is unlikely to interact with drugs that inhibit or induce these enzymes.33 Also, smoking should not affect its pharmacokinetics, like most antipsychotics except the CYP1A2 substrates clozapine and olanzapine whose clearance is affected by cigarette smoking and drugs that induce or inhibit CYP1A2.21 In vitro studies in human liver microsomes showed that iloperidone do not induce CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP3A4 and CYP3A5.33

Efficacy

Positive_regulation (induce) of Gene_expression (studies) of CYP1A2 in liver associated with nicotine addiction
6) Confidence 0.19 Published 2010 Journal Drug design, development and therapy Section Body Doc Link PMC2846148 Disease Relevance 0.48 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox