INT65427

Context Info Confidence 0.60 First Reported 1996 Last Reported 2010 Negated 2 Speculated 1 Reported most in Abstract Documents 7 Total Number 7 Disease Relevance 3.49 Pain Relevance 3.22

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf) plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)

Anatomy Link Frequency neuronal 2 leukocytes 2 brain 2 gut 2 Tnf (Rattus norvegicus)

Pain Link Frequency Relevance Heat ischemia 12 100.00 anesthesia 7 98.96 Clonidine 11 98.50 ketamine 3 98.48 agonist 63 98.30 cytokine 67 96.16 antagonist 7 95.80 Inflammation 59 94.48 Eae 50 94.04 Sciatic nerve 21 92.16

Disease Link Frequency Relevance Heat Cv Unclassified Under Development 9 100.00 Sepsis 8 99.08 Injury 77 96.68 Hemorrhagic Shock 1 96.36 Necrosis 10 95.16 Cancer 10 94.80 INFLAMMATION 79 94.48 Cv General 4 Under Development 16 93.88 Nervous System Injury 19 91.44 Neuropathic Pain 35 80.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Therefore, neuronal bodies and their satellite glial cells are probably responsible for elevation of TNF-?

Spec (probably) Regulation (responsible) of Positive_regulation (elevation) of TNF in neuronal

1) Confidence 0.60 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 1.04 Pain Relevance 0.75

and terbutaline did not have an effect on increasing alveolar fluid clearance in TNF-?

Neg (not) Regulation (effect) of Positive_regulation (increasing) of TNF

2) Confidence 0.44 Published 2004 Journal Crit Care Section Body Doc Link PMC522843 Disease Relevance 0.63 Pain Relevance 0.58

The recruitment of CD45+ leukocytes and the induction of TNF-?

Regulation (recruitment) of Positive_regulation (induction) of TNF in leukocytes

3) Confidence 0.44 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2605224 Disease Relevance 0.34 Pain Relevance 0.15

To test our hypothesis that such a rapid increase of TNF-alpha would be either neurally or hormonally controlled, the effect on TNF-alpha release of anesthesia (ketamine/acepromazine/xylazine) and catecholaminergic agonists and antagonists, either alone or in the presence of LPS, was determined.

Regulation (controlled) of Positive_regulation (increase) of TNF-alpha associated with anesthesia, ketamine, antagonist and agonist

4) Confidence 0.44 Published 2001 Journal Neuroimmunomodulation Section Abstract Doc Link 11752888 Disease Relevance 0.43 Pain Relevance 0.37

These results, taken together, suggest that gut-derived NE upregulates TNF-alpha production in Kupffer cells through an alpha(2)-adrenergic pathway, which appears to be responsible at least in part for the increased levels of circulating TNF-alpha observed during early sepsis as well as other pathophysiologic conditions such as trauma, hemorrhagic shock, or gut ischemia/reperfusion.

Regulation (responsible) of Positive_regulation (increased) of TNF-alpha in gut associated with ischemia, injury, hemorrhagic shock and sepsis

5) Confidence 0.27 Published 2001 Journal Biochim. Biophys. Acta Section Abstract Doc Link 11476962 Disease Relevance 0.39 Pain Relevance 0.24

Furthermore, constitutive TNF alpha, demonstrated to be present in several brain areas, was significantly decreased following administration of the alpha 2-adrenergic agonist clonidine (0.6 mg/kg, i.p., twice daily) to rats for either 1 or 14 days, without a change in TNF alpha mRNA accumulation.

Neg (without) Regulation (change) of Positive_regulation (accumulation) of TNF alpha in brain associated with agonist and clonidine

6) Confidence 0.27 Published 1996 Journal J. Neuroimmunol. Section Abstract Doc Link 8862135 Disease Relevance 0.15 Pain Relevance 0.88

Divergent effects of ischemia/reperfusion and nitric oxide donor on TNFalpha mRNA accumulation in rat organs.

Regulation (effects) of Positive_regulation (accumulation) of TNFalpha associated with ischemia

7) Confidence 0.24 Published 2001 Journal Shock Section Title Doc Link 11303732 Disease Relevance 0.52 Pain Relevance 0.26

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