INT65427

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Context Info
Confidence 0.60
First Reported 1996
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.49
Pain Relevance 3.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf)
plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)
Anatomy Link Frequency
neuronal 2
leukocytes 2
brain 2
gut 2
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 12 100.00 Very High Very High Very High
anesthesia 7 98.96 Very High Very High Very High
Clonidine 11 98.50 Very High Very High Very High
ketamine 3 98.48 Very High Very High Very High
agonist 63 98.30 Very High Very High Very High
cytokine 67 96.16 Very High Very High Very High
antagonist 7 95.80 Very High Very High Very High
Inflammation 59 94.48 High High
Eae 50 94.04 High High
Sciatic nerve 21 92.16 High High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 9 100.00 Very High Very High Very High
Sepsis 8 99.08 Very High Very High Very High
Injury 77 96.68 Very High Very High Very High
Hemorrhagic Shock 1 96.36 Very High Very High Very High
Necrosis 10 95.16 Very High Very High Very High
Cancer 10 94.80 High High
INFLAMMATION 79 94.48 High High
Cv General 4 Under Development 16 93.88 High High
Nervous System Injury 19 91.44 High High
Neuropathic Pain 35 80.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, neuronal bodies and their satellite glial cells are probably responsible for elevation of TNF-?
Spec (probably) Regulation (responsible) of Positive_regulation (elevation) of TNF in neuronal
1) Confidence 0.60 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 1.04 Pain Relevance 0.75
and terbutaline did not have an effect on increasing alveolar fluid clearance in TNF-?
Neg (not) Regulation (effect) of Positive_regulation (increasing) of TNF
2) Confidence 0.44 Published 2004 Journal Crit Care Section Body Doc Link PMC522843 Disease Relevance 0.63 Pain Relevance 0.58
The recruitment of CD45+ leukocytes and the induction of TNF-?
Regulation (recruitment) of Positive_regulation (induction) of TNF in leukocytes
3) Confidence 0.44 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2605224 Disease Relevance 0.34 Pain Relevance 0.15
To test our hypothesis that such a rapid increase of TNF-alpha would be either neurally or hormonally controlled, the effect on TNF-alpha release of anesthesia (ketamine/acepromazine/xylazine) and catecholaminergic agonists and antagonists, either alone or in the presence of LPS, was determined.
Regulation (controlled) of Positive_regulation (increase) of TNF-alpha associated with anesthesia, ketamine, antagonist and agonist
4) Confidence 0.44 Published 2001 Journal Neuroimmunomodulation Section Abstract Doc Link 11752888 Disease Relevance 0.43 Pain Relevance 0.37
These results, taken together, suggest that gut-derived NE upregulates TNF-alpha production in Kupffer cells through an alpha(2)-adrenergic pathway, which appears to be responsible at least in part for the increased levels of circulating TNF-alpha observed during early sepsis as well as other pathophysiologic conditions such as trauma, hemorrhagic shock, or gut ischemia/reperfusion.
Regulation (responsible) of Positive_regulation (increased) of TNF-alpha in gut associated with ischemia, injury, hemorrhagic shock and sepsis
5) Confidence 0.27 Published 2001 Journal Biochim. Biophys. Acta Section Abstract Doc Link 11476962 Disease Relevance 0.39 Pain Relevance 0.24
Furthermore, constitutive TNF alpha, demonstrated to be present in several brain areas, was significantly decreased following administration of the alpha 2-adrenergic agonist clonidine (0.6 mg/kg, i.p., twice daily) to rats for either 1 or 14 days, without a change in TNF alpha mRNA accumulation.
Neg (without) Regulation (change) of Positive_regulation (accumulation) of TNF alpha in brain associated with agonist and clonidine
6) Confidence 0.27 Published 1996 Journal J. Neuroimmunol. Section Abstract Doc Link 8862135 Disease Relevance 0.15 Pain Relevance 0.88
Divergent effects of ischemia/reperfusion and nitric oxide donor on TNFalpha mRNA accumulation in rat organs.
Regulation (effects) of Positive_regulation (accumulation) of TNFalpha associated with ischemia
7) Confidence 0.24 Published 2001 Journal Shock Section Title Doc Link 11303732 Disease Relevance 0.52 Pain Relevance 0.26

General Comments

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