INT6544

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Context Info
Confidence 0.59
First Reported 1980
Last Reported 2007
Negated 1
Speculated 1
Reported most in Abstract
Documents 67
Total Number 68
Disease Relevance 8.05
Pain Relevance 47.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck)
Anatomy Link Frequency
bile 8
duodenum 6
plasma 4
caudate-putamen 4
frontal cortex 4
Cck (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 384 100.00 Very High Very High Very High
gABA 47 100.00 Very High Very High Very High
Somatostatin 43 100.00 Very High Very High Very High
substance P 26 100.00 Very High Very High Very High
cerebral cortex 16 100.00 Very High Very High Very High
tetrodotoxin 16 100.00 Very High Very High Very High
Periaqueductal grey 14 100.00 Very High Very High Very High
Anterior cingulate cortex 10 100.00 Very High Very High Very High
Dorsal horn 10 100.00 Very High Very High Very High
Hippocampus 10 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 22 100.00 Very High Very High Very High
Exocrine Pancreatic Insufficiency 3 99.96 Very High Very High Very High
Obesity 12 99.84 Very High Very High Very High
INFLAMMATION 4 99.70 Very High Very High Very High
Arthritis 3 99.58 Very High Very High Very High
Bordatella Infection 2 99.46 Very High Very High Very High
Injury 6 98.88 Very High Very High Very High
Sprains And Strains 6 98.68 Very High Very High Very High
Pancreatitis 43 98.20 Very High Very High Very High
Pain 5 95.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Release media from cerebral cortex or cp (called 'conditioned media' or CM) inhibits the release of CCK from fresh slices of cp but not from cerebral cortex.
Negative_regulation (inhibits) of Localization (release) of CCK in cerebral cortex associated with cholecystokinin and cerebral cortex
1) Confidence 0.59 Published 1987 Journal Brain Res. Section Abstract Doc Link 2884011 Disease Relevance 0 Pain Relevance 1.05
Topical application of either the L-type calcium channel blocker verapamil (50 microg) or the N-type calcium channel blocker omega-conotoxin GVIA (0.4 microg) onto the dorsal spinal cord completely prevented the CCK-LI release induced by morphine (5 mg/kg, s.c.).
Negative_regulation (prevented) of Localization (release) of CCK in spinal cord associated with calcium channel, cholecystokinin, morphine, spinal cord and conotoxin
2) Confidence 0.59 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10461906 Disease Relevance 0 Pain Relevance 1.87
Cholecystokinin (CCK) release was artificially prevented by the continuous infusion of bile with trypsin into the duodenal lumen throughout the experimental period to avoid the modification of pancreatic response by CCK.
Negative_regulation (prevented) of Localization (release) of Cholecystokinin in lumen associated with bile and cholecystokinin
3) Confidence 0.59 Published 2000 Journal Pancreas Section Abstract Doc Link 10630389 Disease Relevance 0 Pain Relevance 0.40
While some of these compounds inhibited CCK release, their rank order potency (Dex = Lev greater than PCP = PCMP greater than DTG = MK-801 = (+)-3-PPP) differs from that of known PCP-N-methyl-D-aspartate linked effects or sigma interactions.
Negative_regulation (inhibited) of Localization (release) of CCK associated with cholecystokinin and potency
4) Confidence 0.58 Published 1990 Journal Brain Res. Section Abstract Doc Link 2171716 Disease Relevance 0 Pain Relevance 0.52
An injection of CGRP (1 nmol/10 microl) into the left lateral cerebral ventricle (i.c.v.) inhibited pancreatic secretion as well as cholecystokinin (CCK) release induced by bile-pancreatic juice diversion.
Negative_regulation (inhibited) of Localization (release) of CCK in bile associated with bile and cholecystokinin
5) Confidence 0.58 Published 2000 Journal Jpn. J. Physiol. Section Abstract Doc Link 10880881 Disease Relevance 0 Pain Relevance 0.48
Also, we show that CCK-8 release is inhibited by the mu-selective opioid receptor agonist DAGOL.
Negative_regulation (inhibited) of Localization (release) of CCK-8 associated with agonist and opioid receptor
6) Confidence 0.58 Published 1989 Journal FEBS Lett. Section Abstract Doc Link 2753130 Disease Relevance 0.08 Pain Relevance 0.58
Both postprandial CCK secretion and gallbladder contraction in patients after DPRHP (78 +/- 16 pM. 120 min; 47% +/- 6%) and patients with CP (72 +/- 18 pM.120 min; 40% +/- 7%) were significantly reduced (P < 0.05) compared with controls (151 +/- 13 pM.120 min; 74% +/- 4%).
Negative_regulation (reduced) of Localization (secretion) of CCK
7) Confidence 0.58 Published 1997 Journal Scand. J. Gastroenterol. Section Body Doc Link 9299664 Disease Relevance 0 Pain Relevance 0
The inhibitory effect of trypsin on cholecystokinin release was enzyme and site specific, since inhibition of cholecystokinin release was not observed with perfusion of amylase into the duodenum or with trypsin into the ileum.
Negative_regulation (effect) of Localization (release) of cholecystokinin in duodenum associated with cholecystokinin
8) Confidence 0.58 Published 1986 Journal Am. J. Physiol. Section Abstract Doc Link 3953805 Disease Relevance 0 Pain Relevance 0.49
The data suggest that 5-HT3 receptor antagonists prevent the release of CCK evoked by endogenous 5-hydroxytryptamine.
Negative_regulation (prevent) of Localization (release) of CCK associated with antagonist
9) Confidence 0.57 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8446179 Disease Relevance 0.15 Pain Relevance 0.34
Peptide YY (PYY), a known inhibitor of both pancreatic secretion and the release of cholecystokinin (CCK), may play a role in the pathophysiology of acute pancreatitis (AP).
Negative_regulation (inhibitor) of Localization (release) of CCK associated with pancreatitis and cholecystokinin
10) Confidence 0.57 Published 1993 Journal Am. J. Surg. Section Abstract Doc Link 7685154 Disease Relevance 0.50 Pain Relevance 0.15
Since CCK secretion may be reduced in patients with pancreatic insufficiency (PI), we studied postprandial gallbladder motility in these patients.
Negative_regulation (reduced) of Localization (secretion) of CCK associated with exocrine pancreatic insufficiency
11) Confidence 0.56 Published 1997 Journal J. Hepatol. Section Abstract Doc Link 9288605 Disease Relevance 0.17 Pain Relevance 0.26
No changes in CCK-8 release were induced by epinephrine, norepinephrine, dopamine, acetylcholine, or 5-hydroxytryptamine at 10(-5) and 10(-4) M, but gamma-aminobutyric acid (GABA) at 10(-4) M inhibited CCK-8 release.
Negative_regulation (inhibited) of Localization (release) of CCK-8 associated with gaba and dopamine
12) Confidence 0.53 Published 1991 Journal Endocrinology Section Abstract Doc Link 1683280 Disease Relevance 0 Pain Relevance 0.56
Depolarization of the cells with K+ (6 x 10(-2) M) evoked CCK-8 release and this response was blocked by the Ca++ channel blocker verapamil (2 x 10(-5) M) and by Ca++ free medium.
Negative_regulation (blocked) of Localization (release) of CCK-8
13) Confidence 0.53 Published 1991 Journal Endocrinology Section Abstract Doc Link 1683280 Disease Relevance 0 Pain Relevance 0.31
The Na+ channel opener veratridine (10(-4) M) stimulated CCK-8 release and was blocked by the Na+ channel blocker tetrodotoxin (10(-6) M) and by Ca++ free medium.
Negative_regulation (blocked) of Localization (release) of CCK-8 associated with tetrodotoxin
14) Confidence 0.53 Published 1991 Journal Endocrinology Section Abstract Doc Link 1683280 Disease Relevance 0 Pain Relevance 0.41
Several lines of evidence indicate that the release of CCK from cp is inhibited by some other substance (or substances) released by a Ca2+-dependent mechanism from cp along with CCK.
Negative_regulation (inhibited) of Localization (release) of CCK associated with cholecystokinin
15) Confidence 0.43 Published 1987 Journal Brain Res. Section Abstract Doc Link 2884011 Disease Relevance 0 Pain Relevance 1.03
Opiates, morphine and [D-Ala2-D-Leu5]-enkephalin (DADLE), inhibited the K+-stimulated release of cholecystokinin (CCK) from the hypothalamus of both Zucker obese (fa/fa) and lean (Fa/-) rats, in vitro.
Negative_regulation (inhibited) of Localization (release) of CCK in hypothalamus associated with obesity, enkephalin, opiate, cholecystokinin and morphine
16) Confidence 0.43 Published 1985 Journal Brain Res. Section Abstract Doc Link 3896389 Disease Relevance 0.42 Pain Relevance 0.98
Arthritis-induced increase in cholecystokinin release in the rat anterior cingulate cortex is reversed by diclofenac.
Negative_regulation (reversed) of in cingulate cortex Localization (release) of cholecystokinin in anterior associated with diclofenac, anterior cingulate cortex, cholecystokinin and arthritis
17) Confidence 0.43 Published 2007 Journal Brain Res. Section Title Doc Link 17229410 Disease Relevance 0.47 Pain Relevance 1.37
CCK-stimulated amylase secretion from pancreatic acini and binding capacity of 125I-labelled CCK-8 were decreased in obese versus lean rats.
Negative_regulation (decreased) of Localization (secretion) of CCK-stimulated associated with obesity
18) Confidence 0.43 Published 1997 Journal Regul. Pept. Section Abstract Doc Link 9272621 Disease Relevance 0.64 Pain Relevance 0.26
In patients after DPRHP, fasting plasma CCK levels were significantly (p < 0.01) increased, pointing to the absence of feedback inhibition on CCK secretion by intraluminal enzymes.
Negative_regulation (absence) of Localization (secretion) of CCK in plasma associated with cholecystokinin
19) Confidence 0.43 Published 1999 Journal Pancreas Section Abstract Doc Link 10438157 Disease Relevance 0.40 Pain Relevance 0.97
In patients after Whipple's operation, CCK secretory capacity and postprandial CCK secretion were significantly (p < 0.05) reduced.
Negative_regulation (reduced) of Localization (secretion) of CCK associated with cholecystokinin
20) Confidence 0.43 Published 1999 Journal Pancreas Section Abstract Doc Link 10438157 Disease Relevance 0.43 Pain Relevance 1.07

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