INT65443

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Context Info
Confidence 0.49
First Reported 1996
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.59
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (BHLHE22)
Anatomy Link Frequency
smooth muscle 1
arms 1
BHLHE22 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 2 99.22 Very High Very High Very High
IPN 4 95.84 Very High Very High Very High
opioid receptor 2 95.16 Very High Very High Very High
Catecholamine 1 92.72 High High
Potency 1 82.96 Quite High
agonist 6 80.00 Quite High
Neuropeptide 3 75.00 Quite High
metalloproteinase 2 75.00 Quite High
Enkephalin 3 72.76 Quite High
Pain 2 65.24 Quite High
Disease Link Frequency Relevance Heat
Adhesions 3 98.24 Very High Very High Very High
Obesity 4 77.48 Quite High
Pain 2 65.24 Quite High
Bordatella Infection 1 61.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Opioid mu, delta, and kappa receptor-induced activation of phospholipase C-beta 3 and inhibition of adenylyl cyclase is mediated by Gi2 and G(o) in smooth muscle.
Positive_regulation (activation) of beta 3 in smooth muscle associated with opioid
1) Confidence 0.49 Published 1996 Journal Mol. Pharmacol. Section Title Doc Link 8863832 Disease Relevance 0.06 Pain Relevance 0.36
Interestingly, NPAF increased the mRNA levels of beta2- and beta3-adrenergic receptors (AR), and to a lesser extent those of beta1-ARs.
Positive_regulation (increased) of beta3
2) Confidence 0.45 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12149260 Disease Relevance 0.29 Pain Relevance 0.30
These results demonstrate the importance of beta1 and beta3 containing integrins in mediating monocyte adhesion onto RGD immobilized onto flexible PEG arms of the IPN.
Positive_regulation (importance) of beta3 in arms associated with ipn and adhesions
3) Confidence 0.28 Published 2007 Journal Biomaterials Section Abstract Doc Link 16979234 Disease Relevance 0.24 Pain Relevance 0.40

General Comments

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