INT65443

Context Info Confidence 0.49 First Reported 1996 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 0.59 Pain Relevance 1.06

nucleus (BHLHE22)

Anatomy Link Frequency smooth muscle 1 arms 1 BHLHE22 (Homo sapiens)

Pain Link Frequency Relevance Heat Opioid 2 99.22 IPN 4 95.84 opioid receptor 2 95.16 Catecholamine 1 92.72 Potency 1 82.96 agonist 6 80.00 Neuropeptide 3 75.00 metalloproteinase 2 75.00 Enkephalin 3 72.76 Pain 2 65.24

Disease Link Frequency Relevance Heat Adhesions 3 98.24 Obesity 4 77.48 Pain 2 65.24 Bordatella Infection 1 61.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Opioid mu, delta, and kappa receptor-induced activation of phospholipase C-beta 3 and inhibition of adenylyl cyclase is mediated by Gi2 and G(o) in smooth muscle.

Positive_regulation (activation) of beta 3 in smooth muscle associated with opioid

1) Confidence 0.49 Published 1996 Journal Mol. Pharmacol. Section Title Doc Link 8863832 Disease Relevance 0.06 Pain Relevance 0.36

Interestingly, NPAF increased the mRNA levels of beta2- and beta3-adrenergic receptors (AR), and to a lesser extent those of beta1-ARs.

Positive_regulation (increased) of beta3

2) Confidence 0.45 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12149260 Disease Relevance 0.29 Pain Relevance 0.30

These results demonstrate the importance of beta1 and beta3 containing integrins in mediating monocyte adhesion onto RGD immobilized onto flexible PEG arms of the IPN.

Positive_regulation (importance) of beta3 in arms associated with ipn and adhesions

3) Confidence 0.28 Published 2007 Journal Biomaterials Section Abstract Doc Link 16979234 Disease Relevance 0.24 Pain Relevance 0.40

General Comments

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