INT65452

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Context Info
Confidence 0.09
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 0.80
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cacna1c) plasma membrane (Cacna1c) nucleus (Cacna1c)
transmembrane transport (Cacna1c) cytoplasm (Cacna1c)
Anatomy Link Frequency
pituitary 1
smooth muscle cells 1
GH3 1
Cacna1c (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 1 99.08 Very High Very High Very High
GABAergic 1 96.08 Very High Very High Very High
local anesthetic 1 94.96 High High
Delta opioid receptors 3 90.64 High High
addiction 18 90.00 High High
Enkephalin 3 88.24 High High
opioid receptor 3 85.64 High High
Locus ceruleus 5 83.76 Quite High
Opioid 1 83.12 Quite High
Action potential 15 82.04 Quite High
Disease Link Frequency Relevance Heat
Disease 50 99.26 Very High Very High Very High
Cardiovascular Disorder Under Development 1 98.80 Very High Very High Very High
Hypercapnia 1 95.20 Very High Very High Very High
Adhesions 1 79.20 Quite High
Acidosis 1 75.96 Quite High
Stress 9 54.00 Quite High
Natriuresis 10 50.00 Quite Low
Targeted Disruption 18 39.92 Quite Low
Diabetes Mellitus 10 34.88 Quite Low
Hypertension 7 34.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Such cardiotoxicity might involve an inhibition of cardiac L-type Ca2+ current (ICa,L).
Negative_regulation (inhibition) of L-type
1) Confidence 0.09 Published 1997 Journal Anesthesiology Section Abstract Doc Link 9357896 Disease Relevance 0.10 Pain Relevance 0.09
Right change in L-type Ca2+ channel current density (I) in percent b after application of 10 nM Ang II, 100 nM ANP or ANP and Ang II (n = 7 cells from 3 mice) and d after application of 100 nM ISO, 100 nM ANP or ANP and ISO (n = 5 cells from 3 mice); *P < 0.05 versus B, basal
Negative_regulation (density) of L-type
2) Confidence 0.05 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0 Pain Relevance 0
Left original L-type Ca2+ current traces of two cells at baseline and upon superfusion with 10 nM Ang II (a) or 100 nM ISO (c).
Negative_regulation (Left) of L-type
3) Confidence 0.05 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0 Pain Relevance 0
It has been shown that inactivation of skeletal L-type Ca2+ channels approaches steady-state extremely slowly, on the time scale of tens of seconds [21].
Negative_regulation (inactivation) of L-type
4) Confidence 0.04 Published 2001 Journal BMC Physiol Section Body Doc Link PMC37314 Disease Relevance 0 Pain Relevance 0.04
Reduction of L-type Ca(2+)-current restrains synchronization.
Negative_regulation (Reduction) of L-type
5) Confidence 0.03 Published 2008 Journal J. Neurophysiol. Section Abstract Doc Link 18184883 Disease Relevance 0 Pain Relevance 0.12
In order to determine whether blocking L-type Ca2+ channels affected the frequency at which sDeps were detected, the effect of nifedipine was assessed.
Spec (whether) Negative_regulation (blocking) of L-type
6) Confidence 0.02 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2655397 Disease Relevance 0 Pain Relevance 0.13
Activation of cloned rat mu-opioid receptors expressed in GH3 cells (termed GH3MOR cells) inhibits L-type Ca2+ channel activity.
Negative_regulation (inhibits) of L-type Ca2 in GH3 associated with mu opioid receptor
7) Confidence 0.01 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8863841 Disease Relevance 0 Pain Relevance 0.53
Inhibition of L-type Ca(2+) channels by nifedipine reduced HA-induced increased firing rate and eliminated IH-induced increased firing rate.
Negative_regulation (Inhibition) of L-type
8) Confidence 0.01 Published 2003 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 12388081 Disease Relevance 0.17 Pain Relevance 0.26
activation could also contribute to protecting the AD cerebral circulation; these include inhibition of the L-type Ca2+ current (Zhang et al., 1994) and opening of K+ channels (Nomura et al., 2008) in smooth muscle cells, promoting vasorelaxation.
Negative_regulation (inhibition) of L-type Ca2 in smooth muscle cells associated with disease
9) Confidence 0.01 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912024 Disease Relevance 0.53 Pain Relevance 0.04
Since our recent studies have shown that PACAP can induce GH secretion in carp pituitary cells through cAMP/PKA- and Ca2+/calmodulin-dependent mechanisms, these results, taken together, suggest that alpha2-adrenergic stimulation in the carp pituitary may inhibit PACAP-induced GH release and GH gene transcription by blocking the AC/cAMP/PKA pathway and Ca2+ entry through L-type VSCC.
Negative_regulation (blocking) of L-type VSCC in pituitary
10) Confidence 0.00 Published 2007 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 17311897 Disease Relevance 0 Pain Relevance 0.22

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