INT65459

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Context Info
Confidence 0.07
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.57
Pain Relevance 2.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Racgap1) transport (Racgap1) intracellular (Racgap1)
embryo development (Racgap1) cytoplasm (Racgap1) signal transduction (Racgap1)
Anatomy Link Frequency
photoreceptors 1
tail 1
platelet 1
Racgap1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 15 100.00 Very High Very High Very High
5HT 23 99.54 Very High Very High Very High
opioid receptor 8 99.02 Very High Very High Very High
ischemia 174 97.92 Very High Very High Very High
sSRI 5 97.48 Very High Very High Very High
Neurotransmitter 5 96.60 Very High Very High Very High
Calcium channel 1 90.96 High High
sodium channel 7 90.28 High High
Multiple sclerosis 82 85.20 High High
cannabis 1 82.32 Quite High
Disease Link Frequency Relevance Heat
Stress 61 99.78 Very High Very High Very High
Reperfusion Injury 12 98.68 Very High Very High Very High
Cv Unclassified Under Development 62 97.92 Very High Very High Very High
Hypothermia 14 94.28 High High
Traumatic Stress Disorders 1 90.80 High High
Disease 38 88.20 High High
Hemorrhage 2 87.92 High High
Multiple Sclerosis 93 85.20 High High
Cv General 4 Under Development 110 84.52 Quite High
Cognitive Disorder 27 83.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, a peptide designated i4, which was derived from a juxtamembranous region of the carboxyl-terminal tail of the delta-opioid receptor, failed to alter agonist-mediated high affinity GTPase activity or agonist-driven [35S]guanosine 5'-O-thiotriphosphate binding.
GTPase Binding (binding) of in tail associated with agonist and opioid receptor
1) Confidence 0.07 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8863845 Disease Relevance 0.15 Pain Relevance 0.55
Dynamin monomers are 100KD polypeptides containing 5 functional domains: a GTPase domain that binds and hydrolyses GTP, a middle domain that is involved in oligomerization, a GTPase effector domain (GED) that is involved in oligomerization and stimulation of GTPase activity, and plextrin-homology (PH) and proline-rich (PRD) domains that mediate lipid- and protein-protein interactions.
GTPase Binding (binds) of
2) Confidence 0.06 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2916854 Disease Relevance 0.06 Pain Relevance 0.05
Dynamin monomers are 100KD polypeptides containing 5 functional domains: a GTPase domain that binds and hydrolyses GTP, a middle domain that is involved in oligomerization, a GTPase effector domain (GED) that is involved in oligomerization and stimulation of GTPase activity, and plextrin-homology (PH) and proline-rich (PRD) domains that mediate lipid- and protein-protein interactions.
GTPase Binding (binds) of
3) Confidence 0.06 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2916854 Disease Relevance 0.16 Pain Relevance 0.05
In fact, many shared genes are readily identified as being immune related, such as immunity related GTPase, very large Ifn inducible GTPase, IL1?
GTPase Binding (immunity) of
4) Confidence 0.04 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2939656 Disease Relevance 0.42 Pain Relevance 0.18
Furthermore, deletion of Rac1 GTPase in mouse rod photoreceptors via a Cre/Lox approach has been shown to strongly protect rod photoreceptors against photo-oxidative stress [27].
GTPase Binding (deletion) of in photoreceptors associated with stress
5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 1.40 Pain Relevance 0.33
The decrease in oxidative stress following Rac GTPase inhibition is likely due to a correlated significant attenuation of O2?
Rac GTPase Neg (inhibition) Binding (inhibition) of associated with stress
6) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 1.46 Pain Relevance 0.35
Rrad encodes a small GTPase that binds to calmodulin and CaM Kinase II [31].
GTPase Binding (binds) of
7) Confidence 0.03 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2216081 Disease Relevance 0.06 Pain Relevance 0.05
A recent study shows that lamin B functions in mitotic spindle assembly through a process that involves the GTP bound form of the small GTPase Ran.
GTPase Binding (bound) of
8) Confidence 0.02 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.07 Pain Relevance 0
It was recently shown that 5HT can become covalently bound to a number of proteins, a process termed seritonylation, including to small GTPase's, with roles at the vessel wall [272] and in platelet activation [273].
GTPase Binding (bound) of in platelet associated with 5ht
9) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2829540 Disease Relevance 0.79 Pain Relevance 0.73

General Comments

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