INT65460

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Context Info
Confidence 0.69
First Reported 1996
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 1.87
Pain Relevance 3.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprd1) plasma membrane (Oprd1) cytoplasm (Oprd1)
signal transducer activity (Oprd1)
Anatomy Link Frequency
brain 4
spinal cord 2
proximal 2
fibroblasts 2
Oprd1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 55 100.00 Very High Very High Very High
antinociception 9 99.96 Very High Very High Very High
Spinal cord 3 98.80 Very High Very High Very High
MU agonist 1 98.56 Very High Very High Very High
agonist 17 97.52 Very High Very High Very High
Enkephalin 5 97.24 Very High Very High Very High
Kinase C 1 94.40 High High
Kappa opioid receptor 3 93.56 High High
Kinase C inhibitor 1 92.24 High High
Opioid 20 91.52 High High
Disease Link Frequency Relevance Heat
Hypoxia 24 99.88 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 61 99.72 Very High Very High Very High
Sprains And Strains 14 90.40 High High
Injury 4 89.96 High High
Targeted Disruption 23 87.68 High High
Bordatella Infection 1 48.64 Quite Low
Neuroblastoma 1 25.00 Low Low
Glioma 1 25.00 Low Low
Drug Dependence 8 5.00 Very Low Very Low Very Low
Impulse Control Disorders 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We tested the hypothesis that mice exposed to prolonged hypoxia have increased expression of the delta opioid receptor in brain tissue.
Positive_regulation (increased) of Gene_expression (expression) of delta opioid receptor in brain associated with hypoxia and opioid receptor
1) Confidence 0.69 Published 1996 Journal Neuroscience Section Abstract Doc Link 9157323 Disease Relevance 0.70 Pain Relevance 0.36
Deletion of the delta opioid receptor gene increases motor impulsivity
Positive_regulation (increases) of Gene_expression (Deletion) of delta opioid receptor associated with opioid receptor and attention deficit hyperactivity disorder
2) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635474 Disease Relevance 0.40 Pain Relevance 0.14
Shorter term hypoxic treatments (one day and three days) did not induce changes in delta opioid receptor expression in whole brain homogenate.
Neg (not) Positive_regulation (induce) of Gene_expression (expression) of delta opioid receptor in brain associated with hypoxia and opioid receptor
3) Confidence 0.46 Published 1996 Journal Neuroscience Section Abstract Doc Link 9157323 Disease Relevance 0.77 Pain Relevance 0.51
These results indicate a potential role for the phospholipase C-inositol-1,4, 5-trisphosphate pathway in the expression of delta-opioid receptor-mediated antinociception in the mouse spinal cord.
Positive_regulation (role) of Gene_expression (expression) of delta-opioid receptor-mediated in spinal cord associated with antinociception, opioid receptor and spinal cord
4) Confidence 0.42 Published 2000 Journal Neuroscience Section Abstract Doc Link 10938438 Disease Relevance 0 Pain Relevance 1.39
In this paper we propose a powerful procedure to measure functional activation of the mouse delta-opioid receptor transiently expressed in mammalian cells.
Positive_regulation (activation) of Gene_expression (expressed) of delta-opioid receptor associated with opioid receptor
5) Confidence 0.42 Published 1996 Journal Neurochem. Res. Section Abstract Doc Link 8947920 Disease Relevance 0 Pain Relevance 0.20
In membranes from Rat-1 fibroblasts transfected to express the murine delta-opioid receptor stably (clone D2 cells), the delta-opioid agonist [D-Ser2-Leu5-Thr6]enkephalin (DSLET) stimulated high affinity GTPase activity, which was inhibited by peptides that are derived from the proximal (i3.1) and the distal portions (i3.3) of the third intracellular loop with IC50 values of 15 +/- 5 and 50 +/- 4 microM, respectively.
Positive_regulation (transfected) of Gene_expression (express) of delta-opioid receptor in proximal associated with mu agonist, enkephalin and opioid receptor
6) Confidence 0.37 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8863845 Disease Relevance 0 Pain Relevance 0.43
Quantification of G alpha o and G alpha i disclosed striking differences between Sf9 and High 5 insect cells, both of which overexpressed the cloned delta-opioid receptor.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of delta-opioid receptor associated with opioid receptor
7) Confidence 0.28 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9084406 Disease Relevance 0 Pain Relevance 0.46
Adenylyl cyclase activity was measured following labelling of the cellular ATP pool with [3H]adenine in intact Rat-1 fibroblasts that had been stably transfected to express the murine delta-opioid receptor (clone D2).
Positive_regulation (transfected) of Gene_expression (express) of delta-opioid receptor in fibroblasts associated with opioid receptor
8) Confidence 0.06 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9349557 Disease Relevance 0 Pain Relevance 0.37

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