INT65463

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Context Info
Confidence 0.10
First Reported 1996
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.39
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprd1) plasma membrane (Oprd1) cytoplasm (Oprd1)
signal transducer activity (Oprd1)
Anatomy Link Frequency
NG108-15 2
Bri3 (Mus musculus)
Oprd1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 16 100.00 Very High Very High Very High
agonist 10 97.16 Very High Very High Very High
Enkephalin 2 56.56 Quite High
MU agonist 2 55.40 Quite High
Analgesic 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Glioma 2 98.14 Very High Very High Very High
Neuroblastoma 2 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Peptides i3.1 and i3.3 also destabilized the high affinity state of the receptor as assessed in 3H agonist binding on membranes from neuroblastoma X glioma (NG108-15) hybrid cells, which express the delta-opioid receptor endogenously; furthermore, delta-opioid receptor-stimulated GTPase activity in the same membranes was inhibited by peptides i3.1 and i3.3 but i4 was inactive.
i3 Negative_regulation (inhibited) of delta-opioid receptor-stimulated in NG108-15 associated with neuroblastoma, agonist, opioid receptor and glioma
1) Confidence 0.10 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8863845 Disease Relevance 0.20 Pain Relevance 0.47
Peptides i3.1 and i3.3 also destabilized the high affinity state of the receptor as assessed in 3H agonist binding on membranes from neuroblastoma X glioma (NG108-15) hybrid cells, which express the delta-opioid receptor endogenously; furthermore, delta-opioid receptor-stimulated GTPase activity in the same membranes was inhibited by peptides i3.1 and i3.3 but i4 was inactive.
i3 Negative_regulation (inhibited) of delta-opioid receptor-stimulated in NG108-15 associated with neuroblastoma, agonist, opioid receptor and glioma
2) Confidence 0.10 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8863845 Disease Relevance 0.20 Pain Relevance 0.47

General Comments

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