INT65472

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Context Info
Confidence 0.36
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 6.06
Pain Relevance 2.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-G)
Anatomy Link Frequency
leukocyte 2
joint 1
T cells 1
HLA-G (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 124 99.76 Very High Very High Very High
Inflammation 33 98.56 Very High Very High Very High
rheumatoid arthritis 59 95.44 Very High Very High Very High
Arthritis 9 94.16 High High
Multiple sclerosis 3 92.60 High High
tolerance 12 82.64 Quite High
endometriosis 36 73.92 Quite High
imagery 1 65.12 Quite High
cytokine 21 60.64 Quite High
Inflammatory response 2 53.20 Quite High
Disease Link Frequency Relevance Heat
Disease 118 100.00 Very High Very High Very High
Non-small-cell Lung Cancer 18 100.00 Very High Very High Very High
Low Back Pain 128 99.76 Very High Very High Very High
Arthropathy 2 98.84 Very High Very High Very High
INFLAMMATION 33 98.56 Very High Very High Very High
Systemic Sclerosis 1 96.40 Very High Very High Very High
Reprotox - General 1 6 95.64 Very High Very High Very High
Rheumatoid Arthritis 61 95.44 Very High Very High Very High
Cancer 43 95.28 Very High Very High Very High
Seronegative Spondarthritis 4 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although no data have been published on an association between NSCLC and HLA-C so far, we may speculate that the C1C2 genotype may allow for a wider spectrum of KIRs to contribute to control over cancer cells.
HLA-C Binding (association) of associated with cancer and non-small-cell lung cancer
1) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928722 Disease Relevance 0.97 Pain Relevance 0.21
DNA isolation and KIR2DS5 and HLA-C C1/C2 group typing
HLA-C Binding (typing) of
2) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928722 Disease Relevance 0.38 Pain Relevance 0.13
One might argue that the apparent effect of KIR2DS5 in other diseases might be caused by its LD with other KIR2D genes whose products bind HLA-C molecules, distinguishing between C1 and C2 epitopes [1], [2].
HLA-C Spec (might) Binding (bind) of associated with disease
3) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928722 Disease Relevance 0.74 Pain Relevance 0.40
3-domain KIRs (KIR2DL1, 2, and 3) known to recognize HLA-C
HLA-C Binding (recognize) of
4) Confidence 0.35 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804296 Disease Relevance 0.86 Pain Relevance 0.32
They express high levels of inhibitory immunoglobulin like transcript (ILT) receptors, particularly ILT4, and its ligand, HLA-G.
HLA-G Binding (ligand) of
5) Confidence 0.35 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 0.23 Pain Relevance 0.10
BACKGROUND: Human leukocyte antigen B27 (HLA-B27) is a major histocompatibility complex class 1 molecule that is strongly associated with the disease ankylosing spondylitis.
class 1 molecule Binding (associated) of in leukocyte associated with spinal inflammation and disease
6) Confidence 0.15 Published 2005 Journal Cytometry. Part B, Clinical cytometry Section Abstract Doc Link 15624199 Disease Relevance 0.20 Pain Relevance 0.19
Human leukocyte antigen (HLA) class I molecules consist of a heavy chain, beta(2)-microglobulin, and a peptide that are noncovalently bound.
microglobulin Binding (bound) of in leukocyte
7) Confidence 0.05 Published 2008 Journal J. Mol. Biol. Section Abstract Doc Link 18178223 Disease Relevance 0.17 Pain Relevance 0.10
The term spondyloarthropathy (SpA) describes and defines a group of related inflammatory joint disease that share characteristic clinical features and a unique association with the major histocompatibility complex class I molecule HLA-B27.
class I molecule HLA-B27 Binding (association) of in joint associated with inflammation and arthropathy
8) Confidence 0.05 Published 1996 Journal Curr Opin Rheumatol Section Abstract Doc Link 8864578 Disease Relevance 0.94 Pain Relevance 0.47
AS is clearly associated with the MHC class I molecule HLA-B27, and not with MHC class II molecules.
class I molecule Binding (associated) of associated with spinal inflammation
9) Confidence 0.03 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193730 Disease Relevance 1.43 Pain Relevance 0.68
In the first round of analysis, the 112 peptides identified as binding with a KD of 500 nM or less for the relevant HLA class I molecule, were tested for their ability to stimulate CD8+ T cells from a study population of 11 WNV-infected patients.
class I molecule Binding (binding) of in T cells
10) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.14 Pain Relevance 0
A %rank score of, e.g., 5% thus means that only 5% of random peptides are predicted to bind the HLA molecule with an affinity stronger than the identified epitope.
HLA molecule Binding (bind) of
11) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0 Pain Relevance 0
In practice, for a given HLA class I molecule, the predicted binding affinity of the identified epitope was ranked along with the predicted binding affinities of a common set of 1,000,000 random, natural, 9meric peptides for the same HLA molecule.
class I molecule Binding (affinity) of
12) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0 Pain Relevance 0

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