INT65480

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Context Info
Confidence 0.66
First Reported 1996
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 7.53
Pain Relevance 6.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pts) lyase activity (Pts) cellular_component (Pts)
cytoplasm (Pts)
Anatomy Link Frequency
fibroblasts 3
tail 1
proximal 1
Pts (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Tetrahydrobiopterin 41 100.00 Very High Very High Very High
cytokine 6 99.50 Very High Very High Very High
GCH1 17 99.42 Very High Very High Very High
Opioid 2 99.12 Very High Very High Very High
IPN 2 97.96 Very High Very High Very High
depression 7 97.92 Very High Very High Very High
Dopamine 7 97.16 Very High Very High Very High
Serotonin 5 96.80 Very High Very High Very High
Morphine 5 96.20 Very High Very High Very High
headache 5 94.24 High High
Disease Link Frequency Relevance Heat
Syndrome 17 100.00 Very High Very High Very High
Thrombosis 17 98.68 Very High Very High Very High
Neuropathic Pain 2 98.60 Very High Very High Very High
Cancer 6 98.40 Very High Very High Very High
Inflammatory Pain 2 97.96 Very High Very High Very High
Depression 7 97.92 Very High Very High Very High
Anxiety Disorder 11 97.32 Very High Very High Very High
Tension-type Headache 4 94.24 High High
Inborn Genetic Diseases 1 92.72 High High
Dystonia 2 89.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mild PTS was present in 20 children (39%, 95% CI 26-54%).
Gene_expression (present) of PTS
1) Confidence 0.66 Published 2010 Journal Pediatr Blood Cancer Section Body Doc Link 20232430 Disease Relevance 0.16 Pain Relevance 0
CONCLUSIONS: The practices of PTs appeared to be separated into three distinct patterns.
Gene_expression (practices) of PTs
2) Confidence 0.57 Published 2007 Journal J Eval Clin Pract Section Body Doc Link 17518808 Disease Relevance 0 Pain Relevance 0
Prevention of recurrent thrombosis and use of compression elastic stockings are the cornerstones of PTS prevention.
Neg (prevention) Gene_expression (prevention) of PTS associated with syndrome and thrombosis
3) Confidence 0.57 Published 2000 Journal Curr Opin Pulm Med Section Abstract Doc Link 10912643 Disease Relevance 1.25 Pain Relevance 0.06
This study reports the in vitro correction of BH4 deficiency by using retrovirus mediated transfer of the PTPS cDNA into primary fibroblast cultures established from different patients.
Gene_expression (transfer) of PTPS cDNA in fibroblast associated with tetrahydrobiopterin
4) Confidence 0.54 Published 1996 Journal Hum. Gene Ther. Section Abstract Doc Link 8864759 Disease Relevance 0 Pain Relevance 0.52
Retrovirus-mediated gene transfer of 6-pyruvoyl-tetrahydropterin synthase corrects tetrahydrobiopterin deficiency in fibroblasts from hyperphenylalaninemic patients.
Gene_expression (transfer) of 6-pyruvoyl-tetrahydropterin synthase in fibroblasts associated with tetrahydrobiopterin and cytokine
5) Confidence 0.42 Published 1996 Journal Hum. Gene Ther. Section Title Doc Link 8864759 Disease Relevance 0 Pain Relevance 0.54
Following PTPS gene transfer, stimulation with cytokines restored biosynthesis of BH4 in originally defective cells to values comparable to those of heterozygous fibroblasts from clinically healthy subjects.
Gene_expression (transfer) of PTPS gene in fibroblasts associated with tetrahydrobiopterin and cytokine
6) Confidence 0.42 Published 1996 Journal Hum. Gene Ther. Section Abstract Doc Link 8864759 Disease Relevance 0 Pain Relevance 0.51
A significant negative correlation of PTS and CTS was observed in EM patients.
Neg (negative) Gene_expression (negative) of PTS
7) Confidence 0.21 Published 2004 Journal Pain Section Abstract Doc Link 15494185 Disease Relevance 1.75 Pain Relevance 0.83
The resulting minimally amended PABS.PT was used for both GPs and PTs.
Gene_expression (used) of PTs
8) Confidence 0.12 Published 2008 Journal Pain Section Body Doc Link PMC2258319 Disease Relevance 0.68 Pain Relevance 0.57
In the CFU-f assay, again in the control cultures the PTs produced the largest colonies, followed by the Achilles with the tail cells producing the smallest colonies, indicating that the PT cells proliferate at the fastest rate of the tissues tested, a result similar to that found in the human tissue.
Gene_expression (produced) of PTs in tail
9) Confidence 0.10 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2515295 Disease Relevance 0.08 Pain Relevance 0.20
Surveys suggest that PTS is present in 30%-70% of patients, 5 years after an initial symptomatic or asymptomatic, proximal or distal DVT.
Gene_expression (present) of PTS in proximal associated with syndrome and thrombosis
10) Confidence 0.05 Published 2000 Journal Orthopedics Section Abstract Doc Link 10875426 Disease Relevance 1.68 Pain Relevance 0.17
In separate studies the inhibitor of inducible nitric oxide synthase, 2,4 diamino-6-hydroxy pyrimidine (DAHP; a potent inhibitor of tetrahydrobiopterin synthesis, which is a cofactor for the inducible nitric oxide synthase activity) 1.0 gm /kg b.w. was administered to 12 rats intra-peritonealy 1 hr before indomethacin (20 mg/kg) gavages.
Gene_expression (synthesis) of tetrahydrobiopterin associated with tetrahydrobiopterin
11) Confidence 0.01 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC103670 Disease Relevance 0.13 Pain Relevance 0.27
We report that GTP cyclohydrolase (GCH1), the rate-limiting enzyme for tetrahydrobiopterin (BH4) synthesis, is a key modulator of peripheral neuropathic and inflammatory pain.
Gene_expression (synthesis) of tetrahydrobiopterin associated with tetrahydrobiopterin, ipn, neuropathic pain and gch1
12) Confidence 0.01 Published 2006 Journal Nat. Med. Section Abstract Doc Link 17057711 Disease Relevance 0.68 Pain Relevance 0.87
This hypothesis is further supported by the critical recruitment of enzymatically synthesized tetrahydrobiopterin (BH4) both as an essential cofactor for tyrosine hydroxylase-mediated dopamine production and as a secondary electron donor for nitric oxide synthase-mediated nitric oxide (NO) production.
Gene_expression (synthesized) of tetrahydrobiopterin associated with dopamine and tetrahydrobiopterin
13) Confidence 0.00 Published 2007 Journal Int. J. Mol. Med. Section Abstract Doc Link 17982691 Disease Relevance 0 Pain Relevance 0.74
Thus, reduced GCH1 upregulation, here conferred by non-coding and non-splice site GCH1 variants known to lead to decreased tetrahydrobiopterin expression, delays the need for opioid therapy in cancer.
Gene_expression (expression) of tetrahydrobiopterin associated with tetrahydrobiopterin, cancer, gch1 and opioid
14) Confidence 0.00 Published 2010 Journal Pain Section Abstract Doc Link 19959292 Disease Relevance 0.57 Pain Relevance 0.74
Guanosine triphosphate cyclohydrolase 1 (GCH1) is the first enzyme in the tetrahydrobiopterin (BH4) biosynthesis, an important co-factor for the formation of nitric oxide, biogenic amines and serotonin.
Gene_expression (biosynthesis) of tetrahydrobiopterin associated with tetrahydrobiopterin, gch1 and serotonin
15) Confidence 0.00 Published 2008 Journal Mutat. Res. Section Abstract Doc Link 18515178 Disease Relevance 0.54 Pain Relevance 0.43

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