INT65481

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Context Info
Confidence 0.48
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.57
Pain Relevance 2.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pts) lyase activity (Pts) cellular_component (Pts)
cytoplasm (Pts)
Anatomy Link Frequency
fibroblasts 8
Pts (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Tetrahydrobiopterin 29 100.00 Very High Very High Very High
cytokine 8 100.00 Very High Very High Very High
GCH1 4 99.62 Very High Very High Very High
Opioid 2 99.12 Very High Very High Very High
anesthesia 4 92.48 High High
Serotonin 4 90.84 High High
Dopamine 4 90.28 High High
Neurotransmitter 4 89.92 High High
Cancer pain 3 85.40 High High
Pain 4 74.08 Quite High
Disease Link Frequency Relevance Heat
Cancer 4 98.40 Very High Very High Very High
Cancer Pain 3 85.40 High High
Pain 1 74.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study reports the in vitro correction of BH4 deficiency by using retrovirus mediated transfer of the PTPS cDNA into primary fibroblast cultures established from different patients.
Positive_regulation (mediated) of Gene_expression (transfer) of PTPS cDNA in fibroblast associated with tetrahydrobiopterin
1) Confidence 0.48 Published 1996 Journal Hum. Gene Ther. Section Abstract Doc Link 8864759 Disease Relevance 0 Pain Relevance 0.53
This study reports the in vitro correction of BH4 deficiency by using retrovirus mediated transfer of the PTPS cDNA into primary fibroblast cultures established from different patients.
Positive_regulation (transfer) of Gene_expression (transfer) of PTPS cDNA in fibroblast associated with tetrahydrobiopterin
2) Confidence 0.32 Published 1996 Journal Hum. Gene Ther. Section Abstract Doc Link 8864759 Disease Relevance 0 Pain Relevance 0.52
Retrovirus-mediated gene transfer of 6-pyruvoyl-tetrahydropterin synthase corrects tetrahydrobiopterin deficiency in fibroblasts from hyperphenylalaninemic patients.
Positive_regulation (transfer) of Gene_expression (transfer) of 6-pyruvoyl-tetrahydropterin synthase in fibroblasts associated with tetrahydrobiopterin and cytokine
3) Confidence 0.32 Published 1996 Journal Hum. Gene Ther. Section Title Doc Link 8864759 Disease Relevance 0 Pain Relevance 0.54
Following PTPS gene transfer, stimulation with cytokines restored biosynthesis of BH4 in originally defective cells to values comparable to those of heterozygous fibroblasts from clinically healthy subjects.
Positive_regulation (restored) of Gene_expression (transfer) of PTPS gene in fibroblasts associated with tetrahydrobiopterin and cytokine
4) Confidence 0.32 Published 1996 Journal Hum. Gene Ther. Section Abstract Doc Link 8864759 Disease Relevance 0 Pain Relevance 0.52
Thus, reduced GCH1 upregulation, here conferred by non-coding and non-splice site GCH1 variants known to lead to decreased tetrahydrobiopterin expression, delays the need for opioid therapy in cancer.
Positive_regulation (lead) of Gene_expression (expression) of tetrahydrobiopterin associated with tetrahydrobiopterin, cancer, gch1 and opioid
5) Confidence 0.00 Published 2010 Journal Pain Section Abstract Doc Link 19959292 Disease Relevance 0.57 Pain Relevance 0.74

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