INT65489

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Context Info
Confidence 0.59
First Reported 1996
Last Reported 2010
Negated 7
Speculated 5
Reported most in Body
Documents 28
Total Number 33
Disease Relevance 29.17
Pain Relevance 7.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crp)
Anatomy Link Frequency
blood 4
liver 4
heart 4
hepatocytes 2
Thoracic 2
Crp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 316 100.00 Very High Very High Very High
rheumatoid arthritis 285 100.00 Very High Very High Very High
cytokine 116 100.00 Very High Very High Very High
Angina 56 99.68 Very High Very High Very High
transdermal 63 99.62 Very High Very High Very High
Infliximab 156 99.48 Very High Very High Very High
imagery 127 97.92 Very High Very High Very High
spinal inflammation 131 97.88 Very High Very High Very High
Inflammatory marker 46 97.48 Very High Very High Very High
ischemia 9 95.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 410 100.00 Very High Very High Very High
Disease 313 100.00 Very High Very High Very High
Rheumatoid Arthritis 292 100.00 Very High Very High Very High
Coronary Heart Disease 69 100.00 Very High Very High Very High
Appendicitis 36 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 57 99.98 Very High Very High Very High
Cv General 3 Under Development 39 99.68 Very High Very High Very High
Coronary Artery Disease 164 99.58 Very High Very High Very High
Calcification 96 99.20 Very High Very High Very High
Pancreatitis 81 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Polymorphisms in CRP have been associated with differential CRP concentrations among healthy adults, with some evidence for functional effects on CRP expression.
Regulation (effects) of Gene_expression (expression) of CRP
1) Confidence 0.59 Published 2009 Journal Pharmacogenet. Genomics Section Abstract Doc Link 19077918 Disease Relevance 0.35 Pain Relevance 0.12
Simvastatin therapy had no significant effect on CRP levels in these patients.
Neg (no) Regulation (effect) of Gene_expression (levels) of CRP
2) Confidence 0.45 Published 2001 Journal Atherosclerosis Section Abstract Doc Link 11472751 Disease Relevance 0.61 Pain Relevance 0.08
[The effects of early application of simvastatin on C-reactive protein level, blood lipids, and the clinical course of acute coronary syndrome].
Regulation (effects) of Gene_expression (level) of C-reactive protein in blood associated with acute coronary syndrome
3) Confidence 0.45 Published 2007 Journal Klin Med (Mosk) Section Title Doc Link 18219956 Disease Relevance 0.87 Pain Relevance 0
The sensitivity and specificity of TLC, CRP and percentage of neutrophil in the diagnosis of acute appendicitis was calculated individually and in combination.
Regulation (calculated) of Gene_expression (sensitivity) of CRP in neutrophil associated with appendicitis
4) Confidence 0.44 Published 2009 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2702981 Disease Relevance 1.18 Pain Relevance 0.24
In this systematic review and meta-analysis, the researchers ask whether the evidence for an association between blood levels of C-reactive protein (CRP, an inflammatory protein) and subsequent fatal and nonfatal events affecting the heart and circulation (cardiovascular events) among patients with stable coronary artery disease supports the routine measurement of CRP as recommended in clinical practice guidelines.
Regulation (affecting) of in heart Gene_expression (levels) of CRP in blood associated with coronary artery disease and inflammation
5) Confidence 0.44 Published 2010 Journal PLoS Medicine Section Abstract Doc Link PMC2879408 Disease Relevance 1.14 Pain Relevance 0.05
In this systematic review and meta-analysis, the researchers ask whether the evidence for an association between blood levels of C-reactive protein (CRP, an inflammatory protein) and subsequent fatal and nonfatal events affecting the heart and circulation (cardiovascular events) among patients with stable coronary artery disease supports the routine measurement of CRP as recommended in clinical practice guidelines.
Regulation (affecting) of in heart Gene_expression (levels) of C-reactive protein in blood associated with coronary artery disease and inflammation
6) Confidence 0.44 Published 2010 Journal PLoS Medicine Section Abstract Doc Link PMC2879408 Disease Relevance 1.14 Pain Relevance 0.05
Finally, patients receiving other DMARDs or TNF blockers as monotherapy had a trend for higher CRP levels.
Regulation (trend) of Gene_expression (levels) of CRP
7) Confidence 0.40 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794519 Disease Relevance 0.29 Pain Relevance 0.61
At 72 h after coronary stenting, CRP levels were the only determinants of ICAM-1 concentrations by multiple linear regression analysis.
Spec (determinants) Regulation (determinants) of Gene_expression (levels) of CRP
8) Confidence 0.39 Published 2005 Journal Clin Cardiol Section Body Doc Link 15704532 Disease Relevance 0.07 Pain Relevance 0
Also, we did not find significant differences in CRP and ESR levels when we compared the subgroups of patients with ineffectiveness in the original and effectiveness in the re-employed course (CRP, P = 0.69; ESR, P = 0.18) or those experiencing ineffectiveness in both courses (CRP, P = 0.58; ESR, P = 0.89).
Neg (not) Regulation (differences) of Gene_expression (levels) of CRP
9) Confidence 0.30 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526609 Disease Relevance 0.08 Pain Relevance 0.07
Also, we did not find significant differences in CRP and ESR levels when we compared the subgroups of patients with ineffectiveness in the original and effectiveness in the re-employed course (CRP, P = 0.69; ESR, P = 0.18) or those experiencing ineffectiveness in both courses (CRP, P = 0.58; ESR, P = 0.89).
Neg (not) Regulation (differences) of Spec (find) Gene_expression (levels) of CRP
10) Confidence 0.30 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526609 Disease Relevance 0.08 Pain Relevance 0.13
Also, we did not find significant differences in CRP and ESR levels when we compared the subgroups of patients with ineffectiveness in the original and effectiveness in the re-employed course (CRP, P = 0.69; ESR, P = 0.18) or those experiencing ineffectiveness in both courses (CRP, P = 0.58; ESR, P = 0.89).
Neg (not) Regulation (differences) of Gene_expression (levels) of CRP
11) Confidence 0.30 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526609 Disease Relevance 0.08 Pain Relevance 0.13
Statin treatment in especially IHD patients could also influence the levels of both YKL-40 and hsCRP, but without this treatment we would expect even higher levels of both markers in the IHD groups.
Regulation (influence) of Gene_expression (levels) of CRP associated with coronary artery disease
12) Confidence 0.26 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 2.31 Pain Relevance 0.21
CRP is a pentameric protein produced mainly by hepatocytes under the control of interleukin-6 as part of the non-specific acute-phase response to tissue damage, infection, inflammation and malignant neoplasia (Pepys and Hirschfield 2003).
Regulation (under) of Gene_expression (produced) of CRP in hepatocytes associated with malignant neoplastic disease, inflammation and infection
13) Confidence 0.25 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350124 Disease Relevance 1.39 Pain Relevance 0.24
In this report, we examined the ability of puerarin to modulate C-reactive protein (CRP) expression and key molecules in the nuclear factor kappa B (NF-kappaB) pathway to determine its molecular target.
Spec (examined) Regulation (modulate) of Gene_expression (expression) of CRP
14) Confidence 0.22 Published 2010 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 20346059 Disease Relevance 0.43 Pain Relevance 0.33
Levels of serum IL-6 and CRP in previous published studies of patients with AS have been conflicting; one reporting lower levels than those in the current study,36 37 and others reporting higher levels.38–40 The reported differences in IL-6 and CRP levels are most likely related to the heterogeneity of the AS patient populations studied.
Regulation (differences) of Gene_expression (levels) of CRP associated with spinal inflammation
15) Confidence 0.18 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564765 Disease Relevance 0.84 Pain Relevance 0.56
Moreover, IL-6 levels were strongly correlated with CRP levels at baseline in the current study, which is consistent with the results of other studies of AS and rheumatoid arthritis.38 41 Moderate correlations were observed between baseline levels of IL-6 and VEGF and between baseline levels of VEGF and CRP.
Regulation (correlated) of Gene_expression (levels) of CRP associated with spinal inflammation and rheumatoid arthritis
16) Confidence 0.18 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564765 Disease Relevance 0.78 Pain Relevance 0.53
In the infliximab group, baseline IL-6 and CRP levels were significantly correlated inversely with changes from baseline to week 24 in MRI activity scores (p?
Regulation (correlated) of Gene_expression (levels) of CRP associated with infliximab and imagery
17) Confidence 0.18 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564765 Disease Relevance 0.37 Pain Relevance 0.48
The measurement of C reactive protein (CRP) is also a useful tool since CRP synthesis is dependent on IL-6 (Park et al 2005).


Regulation (dependent) of Gene_expression (synthesis) of CRP
18) Confidence 0.18 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 0.47 Pain Relevance 0.07
The characteristics of RA patients, including their age, sex, disease duration, ANA, ANC, CRP, sH4 levels, clinical treatment, and DAS28 score, are summarized in Table S1.
Regulation (age) of Gene_expression (levels) of CRP associated with rheumatoid arthritis and disease
19) Confidence 0.16 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 0.72 Pain Relevance 0.31
The characteristics of RA patients, including their age, sex, disease duration, ANA, ANC, CRP, sH4 levels, clinical treatment, and DAS28 score, are summarized in Table S1.
Regulation (characteristics) of Gene_expression (levels) of CRP associated with rheumatoid arthritis and disease
20) Confidence 0.16 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 0.73 Pain Relevance 0.31

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