INT655

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Context Info
Confidence 0.70
First Reported 1975
Last Reported 2010
Negated 3
Speculated 6
Reported most in Abstract
Documents 86
Total Number 94
Disease Relevance 32.41
Pain Relevance 13.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (REN) extracellular space (REN) extracellular region (REN)
intracellular (REN) response to stress (REN)
Anatomy Link Frequency
plasma 22
blood 18
renal nerve 12
kidney 10
sympathetic 6
REN (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 37 100.00 Very High Very High Very High
Catecholamine 31 100.00 Very High Very High Very High
tolerance 17 100.00 Very High Very High Very High
Serotonin 13 99.98 Very High Very High Very High
Dopamine 25 99.84 Very High Very High Very High
opiate 25 99.80 Very High Very High Very High
ischemia 51 99.76 Very High Very High Very High
narcan 22 99.68 Very High Very High Very High
cINOD 20 99.44 Very High Very High Very High
substance P 14 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 86 100.00 Very High Very High Very High
Renal Artery Obstruction 70 100.00 Very High Very High Very High
Natriuresis 55 100.00 Very High Very High Very High
Cv Unclassified Under Development 39 100.00 Very High Very High Very High
Hypertension 531 99.92 Very High Very High Very High
Pressure And Volume Under Development 198 99.92 Very High Very High Very High
Increased Venous Pressure Under Development 107 99.90 Very High Very High Very High
Heart Rate Under Development 40 99.90 Very High Very High Very High
Hyperaldosteronism 14 99.74 Very High Very High Very High
Hypotension 37 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sodium nitroprusside increased renin secretion, which was not seen with adenosine.
Positive_regulation (increased) of Localization (secretion) of renin associated with adenocard
1) Confidence 0.70 Published 1990 Journal Anesth. Analg. Section Abstract Doc Link 2240636 Disease Relevance 0.51 Pain Relevance 0.30
CONCLUSION: Our results indicate a key role of renal sympathetic fibers in mediating renin release during hypotension in humans, and that epidural anesthesia interferes with the functional integrity of the renin-angiotensin system.


Positive_regulation (mediating) of Localization (release) of renin in sympathetic
2) Confidence 0.70 Published 1994 Journal Anesthesiology Section Body Doc Link 8017664 Disease Relevance 0 Pain Relevance 0
Veratridine (10-300 microM) significantly increased active renin secretion and produced a small but nonsignificant rise in inactive renin secretion in all three groups of animals (P less than 0.05).
Positive_regulation (increased) of Localization (secretion) of renin
3) Confidence 0.69 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2679151 Disease Relevance 0 Pain Relevance 0.14
Intrarenal perfusion of dopamine (6 mug/kg/min for 10 min) caused a significant increase of renin secretion, together with a significant increase in renal blood flow.
Positive_regulation (increase) of Localization (secretion) of renin in blood associated with dopamine
4) Confidence 0.69 Published 1975 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1175682 Disease Relevance 0.22 Pain Relevance 0.15
(b) Propranolol (intrarenal perfusion of 1 mg/kg in 15 min, then of 4 mg/kg/hr) alters neither the renal vasodilation nor the renin hypersecretion induced by dopamine.
Neg (neither) Positive_regulation (induced) of Localization (hypersecretion) of renin associated with dopamine and increased venous pressure under development
5) Confidence 0.69 Published 1975 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1175682 Disease Relevance 0.28 Pain Relevance 0.22
The role of intrarenal dopaminergic receptors has been studied: (a) Haloperidol (intrarenal perfusion of 50 mug/kg/min for 20 min) suppresses the renal vasodilation and renin hypersecretion induced by dopamine.
Positive_regulation (induced) of Localization (hypersecretion) of renin associated with dopamine and increased venous pressure under development
6) Confidence 0.69 Published 1975 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1175682 Disease Relevance 0.28 Pain Relevance 0.21
Unilateral renal arterial infusion of sodium thiopental decreased the renin secretion rate and plasma norepinephrine concentration in renal vein, whereas an anesthetic dose of sodium thiopental administered intravenously increased the renin secretion rate.
Positive_regulation (increased) of Localization (secretion) of renin in renal vein
7) Confidence 0.69 Published 1987 Journal Ren Physiol Section Abstract Doc Link 3331472 Disease Relevance 0.10 Pain Relevance 0.09
Thus, sodium depletion stimulates total renin release, while propranolol and clonidine produce divergent responses of active renin and prorenin, the changes in prorenin depending on the changes induced in blood-pressure.
Positive_regulation (stimulates) of Localization (release) of renin in blood associated with clonidine
8) Confidence 0.68 Published 1977 Journal Lancet Section Abstract Doc Link 71600 Disease Relevance 0.14 Pain Relevance 0.20
Renin and aldosterone secretion increase during sleep and are synchronized to the nonREM-REM cycle [36,37].
Positive_regulation (increase) of Localization (secretion) of Renin
9) Confidence 0.68 Published 2003 Journal BMC Psychiatry Section Body Doc Link PMC280657 Disease Relevance 0.32 Pain Relevance 0.33
Intrarenal infusion of phenylephrine (1 microgram/min) did not affect systemic blood pressure or renal blood flow, but increased the renin secretion rate about twofold.
Neg (not) Positive_regulation (increased) of Localization (secretion) of renin in blood
10) Confidence 0.67 Published 1984 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 6200712 Disease Relevance 0 Pain Relevance 0.09
Renin release induced by a nonvasoconstrictor dose of phenylephrine is independent of the renal prostaglandin system in anesthetized dogs.
Positive_regulation (induced) of Localization (release) of Renin associated with anesthesia
11) Confidence 0.67 Published 1984 Journal J. Cardiovasc. Pharmacol. Section Title Doc Link 6200712 Disease Relevance 0 Pain Relevance 0.18
A cyclooxygenase inhibitor, indomethacin (5 mg/kg i.v.), also suppressed the 5-HT-induced renin release.
Positive_regulation (induced) of Localization (release) of renin
12) Confidence 0.67 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1905236 Disease Relevance 0 Pain Relevance 0.17
The intrarenal arterial infusion of a large dose of 5-HT (1 micrograms/kg per min) increased the renin secretion rate with an initial decrease and a subsequent increase in renal blood flow.
Positive_regulation (increased) of Localization (secretion) of renin in blood
13) Confidence 0.67 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1905236 Disease Relevance 0 Pain Relevance 0.16
Central and peripheral adrenergic modulation of carotid sinus-induced renin release.
Positive_regulation (induced) of Localization (release) of renin in sinus
14) Confidence 0.67 Published 1982 Journal Am. J. Physiol. Section Title Doc Link 7039357 Disease Relevance 0.20 Pain Relevance 0.09
We conclude that although prenalterol increases renin secretion rate markedly and may alter renal electrolyte excretion, these effects are not mediated by a direct intrarenal action of the drug.
Positive_regulation (increases) of Localization (secretion) of renin
15) Confidence 0.66 Published 1984 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 6206317 Disease Relevance 0.09 Pain Relevance 0.04
Direct intrarenal prenalterol infusion caused a 60 bpm increase in heart rate and resulted in marked increases in renin secretion rates from both kidneys.
Positive_regulation (increases) of Localization (secretion) of renin in heart associated with heart rate under development
16) Confidence 0.66 Published 1984 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 6206317 Disease Relevance 0.10 Pain Relevance 0.04
The lack of fall of plasma renin activity in the renal artery stenosis patients probably indicates the greater influence of ischaemia and renal baroreceptor stimulation over sympathetically mediated renin release.
Positive_regulation (mediated) of Localization (release) of renin in plasma associated with renal artery obstruction and cv unclassified under development
17) Confidence 0.65 Published 1983 Journal J Hypertens Suppl Section Abstract Doc Link 6400111 Disease Relevance 0.88 Pain Relevance 0.32
Evidence for prostaglandin-independent mechanisms in renin release mediated by alpha adrenoceptors during renal nerve stimulation in anesthetized dogs.
Positive_regulation (mediated) of Localization (release) of renin in renal nerve associated with anesthesia
18) Confidence 0.65 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 6325667 Disease Relevance 0 Pain Relevance 0.10
The effects of intrarenally infused phentolamine (5 micrograms/kg/min) on renin and prostaglandin E2 release induced by renal nerve stimulation (RNS, 2.5-5 Hz) were studied in indomethacin (5 mg/kg i.v.)
Positive_regulation (induced) of Localization (release) of renin in renal nerve
19) Confidence 0.65 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6325667 Disease Relevance 0 Pain Relevance 0
CONCLUSION: Meloxicam inhibited furosemide stimulated renin release, suggesting that in man COX-2 is responsible for prostaglandin synthesis mediating renin release.


Positive_regulation (stimulated) of Localization (release) of renin
20) Confidence 0.63 Published 1998 Journal J. Investig. Med. Section Body Doc Link 9737091 Disease Relevance 0 Pain Relevance 0

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