INT65500

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Context Info
Confidence 0.78
First Reported 1996
Last Reported 2011
Negated 9
Speculated 8
Reported most in Abstract
Documents 605
Total Number 628
Disease Relevance 429.94
Pain Relevance 98.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
brain 35
plaque 22
cleavage 19
neurons 16
hippocampus 12
App (Mus musculus)
App - V717F (4) App - M671L (1)
Pain Link Frequency Relevance Heat
Inflammation 6221 100.00 Very High Very High Very High
Abeta 587 100.00 Very High Very High Very High
sodium channel 233 100.00 Very High Very High Very High
Pain 135 100.00 Very High Very High Very High
Neuropeptide 133 100.00 Very High Very High Very High
Nav1.6 46 100.00 Very High Very High Very High
Hippocampus 3456 99.92 Very High Very High Very High
Sciatic nerve 42 99.92 Very High Very High Very High
tetrodotoxin 43 99.84 Very High Very High Very High
nMDA receptor 344 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 23267 100.00 Very High Very High Very High
Targeted Disruption 18862 100.00 Very High Very High Very High
Alzheimer's Dementia 18369 100.00 Very High Very High Very High
INFLAMMATION 7857 100.00 Very High Very High Very High
Cognitive Disorder 5246 100.00 Very High Very High Very High
Toxicity 924 100.00 Very High Very High Very High
Hypersensitivity 153 99.98 Very High Very High Very High
Neuroblastoma 309 99.96 Very High Very High Very High
Immunization 660 99.92 Very High Very High Very High
Congenital Anomalies 627 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined heterozygous transgenic (Tg) mice that overexpress V717F amyloid precursor protein (APP) for delay eyeblink conditioning (EBC) and hippocampal volume with magnetic resonance imaging (MRI).
Gene_expression (overexpress) of V717F amyloid precursor protein (V717F) associated with targeted disruption, alzheimer's dementia and imagery
1) Confidence 0.78 Published 2002 Journal Neurobiol. Dis. Section Abstract Doc Link 12586551 Disease Relevance 0.42 Pain Relevance 0.20
We examined heterozygous transgenic (Tg) mice that overexpress V717F amyloid precursor protein (APP) for delay eyeblink conditioning (EBC) and hippocampal volume with magnetic resonance imaging (MRI).
Gene_expression (overexpress) of APP associated with targeted disruption, alzheimer's dementia and imagery
2) Confidence 0.78 Published 2002 Journal Neurobiol. Dis. Section Abstract Doc Link 12586551 Disease Relevance 0.42 Pain Relevance 0.20
These results indicate that overexpression of APP or beta amyloid profoundly affects learning and memory and hippocampal volume.
Gene_expression (overexpression) of APP associated with alzheimer's dementia
3) Confidence 0.78 Published 2002 Journal Neurobiol. Dis. Section Abstract Doc Link 12586551 Disease Relevance 0.50 Pain Relevance 0.26
We now show ibuprofen's effects were not mediated by alterations in amyloid precursor protein (APP) expression or oxidative damage (carbonyls).
Gene_expression (expression) of amyloid precursor protein associated with alzheimer's dementia
4) Confidence 0.78 Published 2001 Journal Neurobiol. Aging Section Abstract Doc Link 11755007 Disease Relevance 0.54 Pain Relevance 0.24
We now show ibuprofen's effects were not mediated by alterations in amyloid precursor protein (APP) expression or oxidative damage (carbonyls).
Gene_expression (expression) of APP associated with alzheimer's dementia
5) Confidence 0.78 Published 2001 Journal Neurobiol. Aging Section Abstract Doc Link 11755007 Disease Relevance 0.54 Pain Relevance 0.24
Sciatic nerves of APP overexpressing and FVB/N wild-type mice were transected and immediately resutured.
Gene_expression (overexpressing) of APP in Sciatic nerves associated with sciatic nerve
6) Confidence 0.78 Published 2010 Journal Brain Res. Bull. Section Abstract Doc Link 19958821 Disease Relevance 0.66 Pain Relevance 0.47
The aim of this study was to examine the role of APP overexpression in peripheral nerve regeneration and neuropathic pain-related behavior in mice.
Spec (examine) Gene_expression (overexpression) of APP in peripheral nerve associated with neuropathic pain
7) Confidence 0.78 Published 2010 Journal Brain Res. Bull. Section Abstract Doc Link 19958821 Disease Relevance 0.67 Pain Relevance 0.47
Taken together, our findings suggest that APP overexpression is beneficial for nerve regeneration processes due to better organization of regenerating fibers, increased survival of motoneurons after autotomy and prevention of neuropathic pain.
Gene_expression (overexpression) of APP in nerve associated with neuropathic pain
8) Confidence 0.78 Published 2010 Journal Brain Res. Bull. Section Abstract Doc Link 19958821 Disease Relevance 0.73 Pain Relevance 0.33
APP overexpression prevents neuropathic pain and motoneuron death after peripheral nerve injury in mice.
Gene_expression (overexpression) of APP in motoneuron associated with pain, nervous system injury, neuropathic pain, death and peripheral nerve injury
9) Confidence 0.78 Published 2010 Journal Brain Res. Bull. Section Title Doc Link 19958821 Disease Relevance 0.71 Pain Relevance 0.78
Rodent research has indicated that gestational or early developmental iron deficiency can alter the expression of the APP and CLU genes implicated in synaptic plasticity, dendritic outgrowth, and AD pathogenesis [127–129].
Gene_expression (expression) of APP associated with anaemia and disease
10) Confidence 0.78 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2952897 Disease Relevance 0.88 Pain Relevance 0.16
There is no enlargement of the endosomes in the Ts1Cje mice (no APP overexpression) or in transgenic mice overexpressing APP751 with the Swedish double mutation alone or in combination with the London mutation [49].
Neg (no) Gene_expression (overexpression) of APP associated with targeted disruption
11) Confidence 0.77 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.27 Pain Relevance 0.03
Is its easy recognition in Tg animals the mere consequence of the artificial overexpression of APP?
Gene_expression (overexpression) of APP in mere associated with targeted disruption
12) Confidence 0.77 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.66 Pain Relevance 0
In the APP-C99 (Tg 13592) mouse line, the signal sequence and the 99 amino-acids C terminal fragment (C99) of APP is overexpressed under a cytomegalovirus enhancer/?
Gene_expression (overexpressed) of APP associated with targeted disruption and cytomegalovirus infection
13) Confidence 0.77 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.82 Pain Relevance 0.09
APP expression was driven by the PDGF promoter [98].
Gene_expression (expression) of APP
14) Confidence 0.77 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.42 Pain Relevance 0.04
APP may be expressed at higher levels in regions devoid of plaques than in areas where they are abundant [158].
Gene_expression (expressed) of APP in plaques
15) Confidence 0.77 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 1.00 Pain Relevance 0.06
production as APP is processed by two mutually exclusive pathways.
Gene_expression (production) of APP
16) Confidence 0.77 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.15 Pain Relevance 0.07
Presenilin-2 Mutation Causes Early Amyloid Accumulation and Memory Impairment in a Transgenic Mouse Model of Alzheimer's Disease

In order to clarify the pathophysiological role of presenilin-2 (PS2) carrying the Volga German Kindred mutation (N141I) in a conventional mouse model of Alzheimer's disease (AD) expressing amyloid precursor protein (APP) with the Swedish mutation (Tg2576 line), we generated a double transgenic mouse (PS2Tg2576) by crossbreeding the PS2 mutant with Tg2576 mice.

Gene_expression (expressing) of APP in Mouse associated with targeted disruption, cognitive disorder, alzheimer's dementia and disease
17) Confidence 0.77 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Title Doc Link PMC3018662 Disease Relevance 0.95 Pain Relevance 0
Presenilin-2 Mutation Causes Early Amyloid Accumulation and Memory Impairment in a Transgenic Mouse Model of Alzheimer's Disease

In order to clarify the pathophysiological role of presenilin-2 (PS2) carrying the Volga German Kindred mutation (N141I) in a conventional mouse model of Alzheimer's disease (AD) expressing amyloid precursor protein (APP) with the Swedish mutation (Tg2576 line), we generated a double transgenic mouse (PS2Tg2576) by crossbreeding the PS2 mutant with Tg2576 mice.

Gene_expression (expressing) of amyloid precursor protein in Mouse associated with targeted disruption, cognitive disorder, alzheimer's dementia and disease
18) Confidence 0.77 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Title Doc Link PMC3018662 Disease Relevance 0.95 Pain Relevance 0
The objective of this study was to determine whether tissue NEP specific activity differs according to age and/or across mouse strains, especially those strains predisposed toward formation of Abeta-amyloid plaques following overexpression of the human Alzheimer amyloid precursor protein (APP).
Gene_expression (overexpression) of APP in plaques associated with alzheimer's dementia, sprains and strains, amyloid plaque and abeta
19) Confidence 0.77 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16233955 Disease Relevance 1.18 Pain Relevance 0.31
APP is expressed in all tissues and could undergo cleavage by either ?
Gene_expression (expressed) of APP in cleavage
20) Confidence 0.77 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 1.07 Pain Relevance 0

General Comments

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