INT65501

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Context Info
Confidence 0.62
First Reported 1996
Last Reported 2011
Negated 10
Speculated 5
Reported most in Body
Documents 56
Total Number 61
Disease Relevance 32.51
Pain Relevance 11.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
neuronal 8
brain 5
pituitary 3
neurons 2
vessels 2
App (Mus musculus)
Pain Link Frequency Relevance Heat
Abeta 62 100.00 Very High Very High Very High
Neuropeptide 9 100.00 Very High Very High Very High
nMDA receptor 57 99.98 Very High Very High Very High
cINOD 302 99.86 Very High Very High Very High
isoflurane 18 99.54 Very High Very High Very High
Enkephalin 8 99.32 Very High Very High Very High
Inflammation 533 99.00 Very High Very High Very High
adenocard 6 98.74 Very High Very High Very High
Hippocampus 354 97.80 Very High Very High Very High
dexamethasone 20 97.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 2088 100.00 Very High Very High Very High
Targeted Disruption 1976 100.00 Very High Very High Very High
Generaliased Trisomy 30 100.00 Very High Very High Very High
Hypersensitivity 68 99.98 Very High Very High Very High
Apoptosis 239 99.96 Very High Very High Very High
Anaemia 1 99.90 Very High Very High Very High
Disease 2013 99.76 Very High Very High Very High
Syndrome 157 99.60 Very High Very High Very High
INFLAMMATION 621 99.00 Very High Very High Very High
Aging 125 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rodent research has indicated that gestational or early developmental iron deficiency can alter the expression of the APP and CLU genes implicated in synaptic plasticity, dendritic outgrowth, and AD pathogenesis [127–129].
Regulation (alter) of Gene_expression (expression) of APP associated with anaemia and disease
1) Confidence 0.62 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2952897 Disease Relevance 0.89 Pain Relevance 0.16
M) caused concentration-dependent decreases in LPS-induced BACE, and C99 expression in neuronal cells, but did not change the expression of APP.
Neg (not) Regulation (change) of Gene_expression (expression) of APP in neuronal
2) Confidence 0.56 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2556656 Disease Relevance 0.60 Pain Relevance 0.18
The expression of APP in brain is developmentally regulated and it is expressed ubiquitously in differentiated neurons.
Regulation (regulated) of Gene_expression (expression) of APP in brain
3) Confidence 0.52 Published 2011 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2935165 Disease Relevance 0 Pain Relevance 0.08
peptide, with no alterations in A( processing or APP expression (Shaftel et al., 2007).
Neg (no) Regulation (alterations) of Gene_expression (expression) of APP
4) Confidence 0.48 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2998033 Disease Relevance 0.72 Pain Relevance 0.16
without altering levels of holoAPP.
Neg (without) Regulation (altering) of Gene_expression (levels) of holoAPP
5) Confidence 0.47 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC543463 Disease Relevance 0 Pain Relevance 0
contributes to the hyper-phosphorylation of Tau [78] and regulates the production of the APP derivative A?
Regulation (regulates) of Gene_expression (production) of APP
6) Confidence 0.46 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.27 Pain Relevance 0.05
Modulation of APP transgene
Regulation (Modulation) of Gene_expression (transgene) of APP
7) Confidence 0.45 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.42 Pain Relevance 0.04
The dysregulation in the metabolism of beta-amyloid precursor protein and consequent deposition of amyloid-beta (Abeta) has been envisaged as crucial for the development of neurodegeneration in Alzheimer's disease (AD).
Regulation (dysregulation) of Gene_expression (metabolism) of beta-amyloid precursor protein associated with alzheimer's dementia, disease and abeta
8) Confidence 0.45 Published 2003 Journal Drugs Aging Section Abstract Doc Link 12534311 Disease Relevance 0.63 Pain Relevance 0.14
Transgenic APP expression was activated by crossing the APPswe/ind mice to animals producing tTA under control of the CaMKII?
Regulation (Transgenic) of Gene_expression (expression) of APP associated with targeted disruption
9) Confidence 0.45 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1283364 Disease Relevance 0.30 Pain Relevance 0
Thus, even after accounting for the much higher APP expression levels in our mice than in the Tg2576 and TgCRND8 lines, we have achieved better absolute suppression of A?
Regulation (accounting) of Gene_expression (levels) of APP
10) Confidence 0.45 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1283364 Disease Relevance 0.68 Pain Relevance 0.03
The influence of these factors on production of amyloidogenic peptides (Abeta) is uncertain.
Regulation (influence) of Gene_expression (production) of Abeta associated with abeta
11) Confidence 0.45 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20540990 Disease Relevance 0.17 Pain Relevance 0.46
These data also demonstrate that FMRP and mGluR activation regulate APP synthesis in both FVB and C57BL/6 mice, as the SNs were prepared from the former strain, and the primary cortical neurons from the latter strain.


Regulation (regulate) of Gene_expression (synthesis) of APP in neurons associated with sprains and strains
12) Confidence 0.45 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.80 Pain Relevance 0.08
The effect of trichosanthin on levels of the neuropeptides beta-endorphin (beta-EP) and methionine enkephalin (met-EK) in the mouse brain and pituitary was investigated.
Spec (investigated) Regulation (effect) of Gene_expression (levels) of beta-EP in pituitary associated with neuropeptide and enkephalin
13) Confidence 0.39 Published 1996 Journal Biochem. Mol. Biol. Int. Section Abstract Doc Link 8866015 Disease Relevance 0 Pain Relevance 0.31
In conclusion, the data in the literature indicate a regular drop in the presynaptic marker synaptophysin in the APP transgenic mice; this decrease may be seen in the absence of A?
Regulation (regular) of Gene_expression (transgenic mice) of APP associated with targeted disruption
14) Confidence 0.39 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.59 Pain Relevance 0.26
Mutated human APP transgenes result in the deposition of A?
Regulation (result) of Gene_expression (transgenes) of APP
15) Confidence 0.39 Published 2007 Journal Acta Neuropathol Section Abstract Doc Link PMC2100431 Disease Relevance 0.72 Pain Relevance 0
42 is a necessary condition, but it is not sufficient: Mucke et al. generated different APP transgenic lines under the same promoter (PDGF); they noticed that the overexpression of wild-type hAPP, even if it increased the level of A?
Regulation (under) of Gene_expression (overexpression) of hAPP associated with targeted disruption
16) Confidence 0.39 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.64 Pain Relevance 0.05
42 is a necessary condition, but it is not sufficient: Mucke et al. generated different APP transgenic lines under the same promoter (PDGF); they noticed that the overexpression of wild-type hAPP, even if it increased the level of A?
Regulation (different) of Gene_expression (lines) of APP associated with targeted disruption
17) Confidence 0.39 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.53 Pain Relevance 0.05
Therefore, it seems likely that elevations in both BACE1 and its substrate APP work cooperatively to enable dramatic increases in the intermittent ?
Spec (likely) Regulation (work) of Gene_expression (elevations) of APP
18) Confidence 0.39 Published 2010 Journal Mol Brain Section Body Doc Link PMC2988063 Disease Relevance 0.85 Pain Relevance 0.09
Regardless of treatment, APP levels remained nearly constant over time in KO SNs, as did ?
Regulation (Regardless) of Gene_expression (levels) of APP associated with targeted disruption
19) Confidence 0.39 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.66 Pain Relevance 0
Regardless of treatment, APP levels remained nearly constant over time in KO SNs, as did ?
Regulation (constant) of Gene_expression (levels) of APP associated with targeted disruption
20) Confidence 0.39 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.67 Pain Relevance 0

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