INT65502

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Context Info
Confidence 0.62
First Reported 1996
Last Reported 2011
Negated 12
Speculated 10
Reported most in Body
Documents 77
Total Number 91
Disease Relevance 52.05
Pain Relevance 19.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
cleavage 5
brain 5
neuronal 3
mouth 2
myocytes 2
App (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 233 100.00 Very High Very High Very High
Abeta 128 100.00 Very High Very High Very High
agonist 63 100.00 Very High Very High Very High
anesthesia 45 100.00 Very High Very High Very High
Eae 18 100.00 Very High Very High Very High
opioid receptor 13 100.00 Very High Very High Very High
diclofenac 7 100.00 Very High Very High Very High
Neuropeptide 5 100.00 Very High Very High Very High
aspirin 4 100.00 Very High Very High Very High
Hippocampus 234 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 1129 100.00 Very High Very High Very High
Targeted Disruption 1037 100.00 Very High Very High Very High
Neurodegenerative Disease 144 99.64 Very High Very High Very High
Parkinson's Disease 33 99.60 Very High Very High Very High
Disease 2975 99.58 Very High Very High Very High
Stress 368 99.54 Very High Very High Very High
INFLAMMATION 782 99.48 Very High Very High Very High
Toxicity 101 99.38 Very High Very High Very High
Immunization 29 99.38 Very High Very High Very High
Syndrome 260 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Flurbiprofen also produced a small reduction in Abeta(1-40) in the cortex at 25 mg/kg/day but did not affect Abeta levels in hippocampus or cerebrospinal fluid.
Neg (not) Regulation (affect) of Abeta in cerebrospinal fluid associated with hippocampus and abeta
1) Confidence 0.62 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15340006 Disease Relevance 0.28 Pain Relevance 0.81
Aging and its variants, such as AD, should be viewed as the result of multiple "hits," including alterations in the levels of Abeta, metals, cholinesterase enzymes, and neuronal gene expression.
Regulation (alterations) of Abeta in neuronal associated with aging, disease and abeta
2) Confidence 0.62 Published 2005 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 16387707 Disease Relevance 1.40 Pain Relevance 0.13
APP is developmentally regulated with maximal expression during synaptogenesis and subsequently declines when mature connections are completed [48,49].
Regulation (regulated) of APP
3) Confidence 0.61 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.43 Pain Relevance 0
The levels of betaAPP C-terminal fragments and Notch cleavage were not altered by any of the NSAIDs, indicating that gamma-secretase activity was not overall changed by these drugs.
Neg (not) Regulation (altered) of betaAPP in cleavage associated with cinod
4) Confidence 0.60 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 14690522 Disease Relevance 0.59 Pain Relevance 0.84
Here, we investigated the effect of anesthesia on tau phosphorylation and amyloid precursor protein (APP) metabolism in mouse brain.
Spec (investigated) Regulation (effect) of APP in brain associated with anesthesia, eae and alzheimer's dementia
5) Confidence 0.59 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17376970 Disease Relevance 1.05 Pain Relevance 0.97
Importantly, AICD levels decreased significantly in both BACE1 heterozygous and null mice and it was noted that the removal of one BACE1 gene dramatically reduced AICD without altering other APP cleavage product levels.
Neg (without) Regulation (altering) of APP cleavage product in cleavage
6) Confidence 0.54 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.46 Pain Relevance 0
Within a cellular model, this drug has been shown to regulate APP and A?
Regulation (regulate) of APP
7) Confidence 0.53 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536544 Disease Relevance 0.59 Pain Relevance 0.05
For mutants that predominantly produce Abeta(42), the ability of fenofibrate to further increase Abeta(42) levels became diminished, whereas Abeta(38) levels were altered to varying extents for all mutants analyzed.
Regulation (altered) of Abeta associated with abeta
8) Confidence 0.50 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 17962197 Disease Relevance 0.66 Pain Relevance 0.75
As Zohar discusses, the differential expression of these variants may alter APP turnover and A?
Spec (may) Regulation (alter) of APP
9) Confidence 0.47 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.28 Pain Relevance 0
Cellular levels of holoAPP were not affected by transfection (Figure 5; p < 0.05 versus GFP control).
Neg (not) Regulation (affected) of holoAPP
10) Confidence 0.47 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC543463 Disease Relevance 0 Pain Relevance 0
Many FAD pathologic mutations have been reported in the PS1 gene, and transgenic mouse models have been produced by crossbreeding with APP mutant mice to clarify the pathological role of the PS1 mutation on APP mutant mice, such as PS1Tg2576 [13].
Regulation (role) of APP mutant associated with targeted disruption and disease
11) Confidence 0.45 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3018662 Disease Relevance 1.27 Pain Relevance 0.04
In contrast to changes observed in the hippocampus, the adverse behavioral stress did not significantly affect cortical BACE1 or full-length APP levels in male or female 5XFAD mice (data not shown).
Neg (not) Regulation (affect) of APP in hippocampus associated with stress and hippocampus
12) Confidence 0.45 Published 2010 Journal Mol Brain Section Body Doc Link PMC2988063 Disease Relevance 0.41 Pain Relevance 0.21
Therefore, we developed a mouse model of Alzheimer-type amyloid that expresses a controllable APP transgene.
Regulation (controllable) of APP associated with alzheimer's dementia
13) Confidence 0.45 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1283364 Disease Relevance 0.55 Pain Relevance 0
Our data suggest that multiple cis-regulatory elements of APP mRNA interact with the FMRP-containing RNP complex.


Regulation (cis-regulatory) of APP mRNA
14) Confidence 0.45 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0 Pain Relevance 0
Cardiomyocyte mechanics in myocytes from APP, PS1 and APP/PS1 transgenic murine model
Regulation (model) of APP in myocytes associated with targeted disruption
15) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 0.48 Pain Relevance 0.05
Our data revealed down-regulation of phospholamban, an endogenous inhibitor of SERCA, in APP/PS1 mouse hearts.
Regulation (regulation) of APP/PS1 in hearts
16) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 0.23 Pain Relevance 0
To assess the impact of APP/PS1 mutation on myocardial histology, histological studies were performed using the H&E and Masson's trichrome staining techniques.
Regulation (impact) of APP/PS1
17) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 0.26 Pain Relevance 0.03
Cardiomyocyte mechanics in myocytes from APP, PS1 and APP/PS1 transgenic murine model
Regulation (model) of APP/PS1 in myocytes associated with targeted disruption
18) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 0.48 Pain Relevance 0.05
This finding reproduces in part a study reporting up-regulation of APP mRNA and protein, and increased production of A?
Regulation (regulation) of APP mRNA
19) Confidence 0.44 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC500868 Disease Relevance 0.08 Pain Relevance 0
These data suggest that ibuprofen and naproxen, the most frequently used NSAIDs for the treatment of AD, have an inhibitory effect on Abeta deposition that is independent of the arachidonate cascade and cellular immune systems.
Regulation (effect) of Abeta in immune systems associated with cinod, disease and abeta
20) Confidence 0.44 Published 2009 Journal Brain Res. Section Abstract Doc Link 19666013 Disease Relevance 1.00 Pain Relevance 0.91

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