INT65514

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Context Info
Confidence 0.77
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 25
Total Number 25
Disease Relevance 6.12
Pain Relevance 4.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp1a2) endoplasmic reticulum (Cyp1a2) enzyme binding (Cyp1a2)
response to stress (Cyp1a2)
Anatomy Link Frequency
liver 2
Caco-2 1
2B7 1
kidney 1
Cyp1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 46 99.68 Very High Very High Very High
tolerance 18 98.44 Very High Very High Very High
Morphine 4 97.68 Very High Very High Very High
Nicotine 2 83.64 Quite High
Dextromethorphan 6 82.56 Quite High
lidocaine 3 82.16 Quite High
antagonist 44 78.56 Quite High
anesthesia 7 73.48 Quite High
Pain 10 70.32 Quite High
headache 6 67.60 Quite High
Disease Link Frequency Relevance Heat
Hepatitis 54 99.74 Very High Very High Very High
Toxicity 15 99.60 Very High Very High Very High
Disease 114 98.92 Very High Very High Very High
Pressure Volume 2 Under Development 2 94.76 High High
Autoimmune Hepatitis 507 94.52 High High
Liver Disease 35 92.20 High High
Fungal Infection 27 91.16 High High
Necrosis 6 90.20 High High
Cancer 36 89.84 High High
Primary Sclerosing Cholangitis 21 85.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activity and expression of CYP1A2 did not show obvious differences in the control group and sodium ozagrel treated group.
Gene_expression (expression) of CYP1A2
1) Confidence 0.77 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17651725 Disease Relevance 0 Pain Relevance 0.10
Growth response was measured by changes in DNA, [3H]thymidine incorporation and mRNA of growth related proteins, cell damage by leakage of LDH to the medium and changes in ATP, and protection against toxicity by changes in glutathione, cytochrome p450 and the expression of glutathione-S-transferase and Cyp1A2.
Gene_expression (expression) of Cyp1A2 associated with toxicity
2) Confidence 0.77 Published 2003 Journal Pharmacol. Toxicol. Section Abstract Doc Link 12969438 Disease Relevance 0.32 Pain Relevance 0.57
Suppression of Cyp1A2 expression by pretreatment is assumed to be due to a growth-stimulating effect of low concentrations of acetaminophen.
Gene_expression (expression) of Cyp1A2 associated with paracetamol
3) Confidence 0.77 Published 2003 Journal Pharmacol. Toxicol. Section Abstract Doc Link 12969438 Disease Relevance 0.30 Pain Relevance 0.58
Pretreatment and growth factors protect against acetaminophen toxicity by suppressing the expression of Cyp1A2, thereby reducing the production of the intermediate N-acetyl-p-benzoquinone imine (NAPQI).
Gene_expression (expression) of Cyp1A2 associated with toxicity and paracetamol
4) Confidence 0.77 Published 2003 Journal Pharmacol. Toxicol. Section Abstract Doc Link 12969438 Disease Relevance 0.32 Pain Relevance 0.60
The levels of CYP1A2, 2A6, 2C8, 2D6, and 2E1 were moderate (5-15% of total P450).
Gene_expression (levels) of CYP1A2
5) Confidence 0.75 Published 1996 Journal Biochem. Pharmacol. Section Abstract Doc Link 8866826 Disease Relevance 0 Pain Relevance 0.07
Human P450s (CYP1A2, 2A6, 2B6, 2C8, 2C9, 2C18, 2D6, 2E1, and 3A4) were expressed in Saccharomyces cerevisiae and purified.
Gene_expression (expressed) of CYP1A2
6) Confidence 0.75 Published 1996 Journal Biochem. Pharmacol. Section Abstract Doc Link 8866826 Disease Relevance 0 Pain Relevance 0.08
The administration of ACET down-regulated CYP1A2 and CYP2B1 expression in CD rats, while up-regulating them in NF rats.
Gene_expression (expression) of CYP1A2 associated with paracetamol
7) Confidence 0.74 Published 2009 Journal J Appl Toxicol Section Abstract Doc Link 18798224 Disease Relevance 0 Pain Relevance 0.58
Two mechanisms, as follows in order of importance, are responsible for the effect of liver dysfunction: (1) decreased sensitivity to fluvoxamine of CYP1A2-mediated biotransformations in the cirrhotic liver, probably resulting from reduced uptake of the inhibitory drug, and (2) reduced hepatic expression of CYP1A2, which makes its contribution to overall drug elimination less important.


Gene_expression (expression) of CYP1A2 in liver
8) Confidence 0.72 Published 2006 Journal Clin. Pharmacol. Ther. Section Body Doc Link 16678550 Disease Relevance 0 Pain Relevance 0
Cardiac P450 expression (CYP1A2) assessed by immunoblotting, markedly decreased 48 h after NTG administration in control rats.
Gene_expression (expression) of CYP1A2
9) Confidence 0.67 Published 2006 Journal Free Radic. Biol. Med. Section Abstract Doc Link 16520233 Disease Relevance 0.23 Pain Relevance 0.41
The levels of CYP1A2 and CYP2E1 in hepatic microsomal protein from pretreated group were increased as compared to that from the control group.
Gene_expression (levels) of CYP1A2
10) Confidence 0.58 Published 2007 Journal Yao Xue Xue Bao Section Abstract Doc Link 17520838 Disease Relevance 0 Pain Relevance 0.48
The result indicated that BF significantly increased the activity and protein levels of CYP1A2 and CYP2E1, while the mRNA levels were elevated to a certain extent.
Gene_expression (levels) of CYP1A2
11) Confidence 0.57 Published 2010 Journal J Asian Nat Prod Res Section Abstract Doc Link 20496194 Disease Relevance 0.07 Pain Relevance 0.08
Frequent and sometimes clinically relevant gender differences could be identified for drug elimination processes and were predominantly linked to the sex-specific expression of metabolic enzyme systems, e.g.
Gene_expression (expression) of CYP1A2
12) Confidence 0.55 Published 1999 Journal Int J Clin Pharmacol Ther Section Abstract Doc Link 10584975 Disease Relevance 0.28 Pain Relevance 0.10
In addition, Northern blot analysis showed that CYP1A2, CYP2E1, CYP2C11, and CYP3A1/2 mRNAs decreased in the state of PCM as well.
Gene_expression (decreased) of CYP1A2
13) Confidence 0.51 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15356995 Disease Relevance 0.28 Pain Relevance 0
There were no significant differences in the mRNA expression of CYP1A2, 2B1 and 2E1 among any of the experimental groups.
Gene_expression (expression) of CYP1A2
14) Confidence 0.47 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 14723344 Disease Relevance 0.46 Pain Relevance 0.07
Selected compounds were screened for cytochrome P450 inhibition (CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4), metabolic stability (rat and human liver microsomes), and cell-membrane permeability (Caco-2).
Gene_expression (screened) of CYP1A2 in Caco-2
15) Confidence 0.34 Published 2006 Journal ChemMedChem Section Abstract Doc Link 16892345 Disease Relevance 0 Pain Relevance 0
To assess potential ethnic and gender-related differences in the expression of cytochrome CYP1A2-mediated activity, the pharmacokinetics of phenacetin (a CYP1A2 substrate) and its metabolite paracetamol were compared in 20 Caucasian and 20 Chinese subjects after administration of a single oral 900 mg phenacetin dose.
Gene_expression (expression) of CYP1A2 associated with paracetamol
16) Confidence 0.32 Published 1996 Journal Ther Drug Monit Section Abstract Doc Link 8885124 Disease Relevance 0 Pain Relevance 0.10
CYP1A2, CYP2A6, CYP21, CYP17, and CYP11A1), that are expressed in organs affected by the disease process.
Gene_expression (expressed) of CYP1A2 associated with disease
17) Confidence 0.30 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 1.26 Pain Relevance 0.04
CYP1A1, CYP2A6 and CYP2B6 are expressed both in liver and in kidney resulting to an LKM staining pattern, while CYP1A2 is not expressed in the kidney leading to the LM staining.
Neg (not) Gene_expression (expressed) of CYP1A2 in kidney
18) Confidence 0.30 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 0.41 Pain Relevance 0
It is concluded that there are no major interethnic differences in the expression of CYP1A2-related activity between Caucasians and Chinese, although Chinese women as a subgroup may exhibit comparatively lower enzyme activity.
Gene_expression (expression) of CYP1A2
19) Confidence 0.25 Published 1996 Journal Ther Drug Monit Section Abstract Doc Link 8885124 Disease Relevance 0 Pain Relevance 0.15
Effects of cytochrome P450 isoforms, CYP1A2, CYP2C9 and CYP3A4, on the catalytic activity of UDP-glucuronosyltransferase 2B7 (UGT2B7) expressed in COS cell microsomal membranes were investigated using morphine as a substrate.
Gene_expression (expressed) of CYP1A2 in 2B7 associated with morphine
20) Confidence 0.25 Published 2005 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16204972 Disease Relevance 0 Pain Relevance 0.25

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