INT65515

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Context Info
Confidence 0.36
First Reported 1996
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 6.62
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ocd (Mus musculus)
Pain Link Frequency Relevance Heat
sNRI 8 95.92 Very High Very High Very High
sSRI 210 95.64 Very High Very High Very High
fluoxetine 13 94.80 High High
antidepressant 4 93.76 High High
Neurotransmitter 42 91.56 High High
Glutamate receptor 24 83.12 Quite High
excitatory amino acid 6 74.64 Quite High
Glutamate 102 73.84 Quite High
Serotonin 80 71.48 Quite High
imagery 18 69.52 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 1288 100.00 Very High Very High Very High
Manic Depressive Disorder 20 99.80 Very High Very High Very High
Obsessive-compulsive Disorder 76 94.64 High High
Autism 6 71.20 Quite High
Congenital Anomalies 42 68.72 Quite High
Pain 4 64.28 Quite High
Depression 10 58.84 Quite High
Disease 90 42.80 Quite Low
Phobia 6 30.44 Quite Low
Streptococcal Infections 30 7.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In all three studies, subgroup analysis by gender revealed specific associations of this gene with OCD for males but not females.
OCD Binding (associations) of associated with anxiety disorder
1) Confidence 0.36 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.57 Pain Relevance 0.05
A third independent investigation [89] also confirmed an association between OCD and SLC1A1 for both single marker and haplotype single nucleotide polymorphisms (SNPs) in the 3’ region of the gene, consistent with the earlier studies [83, 84].
OCD Binding (association) of associated with anxiety disorder
2) Confidence 0.32 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.50 Pain Relevance 0.10
Thus, considerable consistency has been established in the reported associations between SLC1A1 and OCD.
OCD Binding (associations) of associated with anxiety disorder
3) Confidence 0.32 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.53 Pain Relevance 0
This is of relevance in terms of management, and may suggest an association between OCD and bipolar disorder.
OCD Binding (association) of associated with manic depressive disorder and anxiety disorder
4) Confidence 0.31 Published 1996 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 8866932 Disease Relevance 0.54 Pain Relevance 0.18
No clear association between SAPAP3 variants and OCD was reported, although it is noteworthy that GDs without OCD were uncommon in this study.
OCD Neg (No) Spec (clear) Binding (association) of associated with anxiety disorder
5) Confidence 0.28 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.84 Pain Relevance 0.03
Delorme et al. [91] investigated potential association between OCD and the ionotropic kainate receptors GRIK2 and GRIK3.
OCD Binding (association) of associated with anxiety disorder
6) Confidence 0.28 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.60 Pain Relevance 0
In 2004, Arnold et al. [79] provided the first report of a positive association between a glutamatergic system gene and OCD.
OCD Binding (association) of associated with anxiety disorder
7) Confidence 0.26 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.71 Pain Relevance 0.30
Again, to validate the predicted association between milnacipran and OCD, we inquired the literature from May 1, 2007 until present for studies that report on a functional relationship between milnacipran and OCD.
OCD Binding (association) of associated with anxiety disorder
8) Confidence 0.05 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2944780 Disease Relevance 1.13 Pain Relevance 0.30
Marble-burying behavior in mice is recognized as a model for OCD [42].
OCD Binding (recognized) of associated with anxiety disorder
9) Confidence 0.05 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2944780 Disease Relevance 1.21 Pain Relevance 0.51

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