INT65524

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Context Info
Confidence 0.21
First Reported 1996
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 3.82
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Spn)
Anatomy Link Frequency
SPN 4
SPN 4
duodenum 1
Spn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neurotransmitter 7 99.44 Very High Very High Very High
Spinal cord 53 97.76 Very High Very High Very High
GABAergic 51 94.96 High High
medulla 3 91.28 High High
potassium channel 9 84.12 Quite High
adenocard 9 81.84 Quite High
antagonist 37 78.48 Quite High
Neuropeptide 4 77.36 Quite High
Enkephalin 2 76.80 Quite High
substance P 3 76.20 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 91 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 12 99.78 Very High Very High Very High
Nerve Root Compression 12 84.28 Quite High
Epilepsy 3 42.96 Quite Low
Pain 3 41.92 Quite Low
Depression 3 25.56 Quite Low
Hypotension 3 10.04 Low Low
Pressure And Volume Under Development 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Decapitation 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One possible explanation for the more moderate responses observed in some SPNs is that the SPN itself is not affected directly by GABAB receptors located on its postsynaptic membrane but that the hyperpolarization is mediated by an effect on neighboring SPNS that are coupled by gap junctions to the recorded neuron and this hyperpolarization is relayed through the gap junctions.
Neg (not) Regulation (affected) of SPN in neuron associated with urological neuroanatomy
1) Confidence 0.21 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0.10 Pain Relevance 0.17
Neurotransmitters/neuromodulators that might influence the activity of SPN acting in the baroreflex-mediated control of blood pressure have been identified.
Spec (might) Regulation (influence) of SPN in SPN associated with neurotransmitter and urological neuroanatomy
2) Confidence 0.20 Published 2002 Journal J. Comp. Neurol. Section Abstract Doc Link 12115667 Disease Relevance 1.30 Pain Relevance 0.34
Other fibers show topographic differences in their contacts with Fos-IR SPN, suggesting that subgroups of hypotension-sensitive SPN are targeted by particular neuron groups.
Regulation (targeted) of SPN in SPN associated with pressure volume 2 under development and urological neuroanatomy
3) Confidence 0.20 Published 2002 Journal J. Comp. Neurol. Section Abstract Doc Link 12115667 Disease Relevance 1.24 Pain Relevance 0.22
These results indicate that the NK1 receptor may play an important role in the regulation of both SPN and of inhibitory interneurones presynaptic to SPN.
Regulation (regulation) of SPN associated with urological neuroanatomy
4) Confidence 0.16 Published 1996 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 8867090 Disease Relevance 0.35 Pain Relevance 0.21
The SPA, SPN, and CA of duodenum in vitro were not obviously affected by injection of morphine (330 nmol/L), but it could selectively inhibit the potentiation of ACh.
Neg (not) Regulation (affected) of SPN in duodenum
5) Confidence 0.16 Published 2002 Journal Acta Pharmacol. Sin. Section Body Doc Link 12100748 Disease Relevance 0 Pain Relevance 0
Thus one avenue for selective regulation of SPN activity would be at a presynaptic level since receptors located on specific presynaptic terminals would influence synaptic transmission exclusively from that input.
Regulation (regulation) of SPN associated with urological neuroanatomy
6) Confidence 0.11 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0.10 Pain Relevance 0.49
This suggests that there are GABAB autoreceptors located on terminals of both descending and local neurons influencing SPN activity.
Regulation (influencing) of SPN in neurons associated with urological neuroanatomy
7) Confidence 0.09 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0.10 Pain Relevance 0.28
However, a greater proportion of (27.3%) our healthy subjects above 60 years had abnormal SPN responses.
Regulation (responses) of SPN in SPN
8) Confidence 0.06 Published 2004 Journal Acta Neurol Taiwan Section Body Doc Link 15508937 Disease Relevance 0.14 Pain Relevance 0
RESULTS: SPN response was found to be abnormal in only 1.6% of group I healthy subjects, but absent or abnormal SPN response was noted in 21.1% of patients with L5 radiculopathy of the same age group (p=0.01).
Regulation (response) of SPN in SPN
9) Confidence 0.06 Published 2004 Journal Acta Neurol Taiwan Section Body Doc Link 15508937 Disease Relevance 0.17 Pain Relevance 0
RESULTS: SPN response was found to be abnormal in only 1.6% of group I healthy subjects, but absent or abnormal SPN response was noted in 21.1% of patients with L5 radiculopathy of the same age group (p=0.01).
Regulation (response) of SPN in SPN
10) Confidence 0.06 Published 2004 Journal Acta Neurol Taiwan Section Body Doc Link 15508937 Disease Relevance 0.16 Pain Relevance 0
RESULTS: SPN response was found to be abnormal in only 1.6% of group I healthy subjects, but absent or abnormal SPN response was noted in 21.1% of patients with L5 radiculopathy of the same age group (p=0.01).
Regulation (abnormal) of SPN in SPN
11) Confidence 0.06 Published 2004 Journal Acta Neurol Taiwan Section Body Doc Link 15508937 Disease Relevance 0.16 Pain Relevance 0

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