INT65527

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Context Info
Confidence 0.46
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.67
Pain Relevance 3.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Adora1) plasma membrane (Adora1) signal transducer activity (Adora1)
Anatomy Link Frequency
lungs 2
Spinal 1
dorsal horn 1
Adora1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 47 100.00 Very High Very High Very High
Dorsal horn 1 99.96 Very High Very High Very High
antinociception 9 99.20 Very High Very High Very High
c fibre 3 98.64 Very High Very High Very High
analgesia 2 97.64 Very High Very High Very High
Antinociceptive 3 97.38 Very High Very High Very High
intrathecal 23 92.00 High High
agonist 15 91.24 High High
Neuropathic pain 3 90.32 High High
addiction 1 90.32 High High
Disease Link Frequency Relevance Heat
Hypersensitivity 3 95.80 Very High Very High Very High
Neuropathic Pain 19 90.32 High High
Nociception 7 77.52 Quite High
Hyperalgesia 2 71.12 Quite High
Pain 5 32.20 Quite Low
Sleep Disorders 7 5.00 Very Low Very Low Very Low
Injury 5 5.00 Very Low Very Low Very Low
Ganglion Cysts 3 5.00 Very Low Very Low Very Low
Nervous System Injury 2 5.00 Very Low Very Low Very Low
Complex Regional Pain Syndromes 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both antinociception and locomotor stimulation appear to be dependent on activation of adenosine A1 receptors, as effects of 3,7-dimethyl-1-propargylxanthine are observed only at a dose which blocks adenosine A1 receptors in addition to A2 receptors.
Positive_regulation (dependent) of Positive_regulation (activation) of adenosine A1 associated with antinociception and adenocard
1) Confidence 0.46 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8867096 Disease Relevance 0 Pain Relevance 0.57
In conclusion, our results showed that infusion of adenosine significantly elevated the sensitivity of pulmonary C-fiber afferents in rat lungs and that this potentiating effect is likely mediated through activation of the adenosine A1 receptor.
Positive_regulation (mediated) of Positive_regulation (activation) of adenosine A1 receptor in lungs associated with c fibre and adenocard
2) Confidence 0.45 Published 2003 Journal J. Appl. Physiol. Section Abstract Doc Link 12754169 Disease Relevance 0.07 Pain Relevance 0.69
This study demonstrates a peripheral antinociceptive action mediated by endogenous adenosine which accumulates following the peripheral inhibition of adenosine kinase; this action is due to activation of an adenosine A1 receptor.
Positive_regulation (due) of Positive_regulation (activation) of adenosine A1 receptor associated with adenocard and antinociceptive
3) Confidence 0.33 Published 1998 Journal Pain Section Abstract Doc Link 9514563 Disease Relevance 0 Pain Relevance 0.82
Spinal adenosine A1 receptor activation induced dorsal horn norepinephrine release, ultimately leading to analgesia by an ?
Positive_regulation (induced) of in dorsal horn Positive_regulation (activation) of adenosine A1 receptor in Spinal associated with adenocard, dorsal horn and analgesia
4) Confidence 0.27 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2908226 Disease Relevance 0.60 Pain Relevance 1.63

General Comments

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