INT65536

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1995
Last Reported 2010
Negated 3
Speculated 2
Reported most in Abstract
Documents 77
Total Number 79
Disease Relevance 38.86
Pain Relevance 33.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nfkb1) DNA binding (Nfkb1) protein complex (Nfkb1)
cytoplasm (Nfkb1) cytosol (Nfkb1) signal transduction (Nfkb1)
Anatomy Link Frequency
nucleus 6
spinal cord 5
brain 4
intestine 4
monocytes 4
Nfkb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 168 100.00 Very High Very High Very High
cytokine 89 100.00 Very High Very High Very High
Analgesic 18 100.00 Very High Very High Very High
substance P 12 100.00 Very High Very High Very High
Eae 12 100.00 Very High Very High Very High
COX2 8 100.00 Very High Very High Very High
cINOD 65 99.98 Very High Very High Very High
ketamine 32 99.98 Very High Very High Very High
dexamethasone 21 99.98 Very High Very High Very High
Gabapentin 12 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 53 100.00 Very High Very High Very High
Necrosis 48 100.00 Very High Very High Very High
Injury 48 100.00 Very High Very High Very High
Alzheimer's Dementia 35 100.00 Very High Very High Very High
Diabetes Mellitus 8 100.00 Very High Very High Very High
Adhesions 16 99.92 Very High Very High Very High
Stress 22 99.90 Very High Very High Very High
Headache 5 99.90 Very High Very High Very High
INFLAMMATION 195 99.88 Very High Very High Very High
Neuroblastoma 6 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These drugs also inhibited NF-kappaB activation in rat spinal dorsal root ganglia cells pre-treated in vitro with substance P.
Negative_regulation (inhibited) of Positive_regulation (activation) of NF-kappaB in dorsal root ganglia associated with substance p
1) Confidence 0.59 Published 2008 Journal J. Cell. Biochem. Section Abstract Doc Link 18615578 Disease Relevance 0.43 Pain Relevance 1.14
Different criteria suggest that the observed effects are mediated at least in part through inhibition of NF-kB activation: R-flurbiprofen inhibited i) LPS-induced NF-kB DNA binding activity in RAW 264.7 macrophages, ii) translocation of the p65 subunit of NF-kB into the nucleus of these cells, and iii) zymosan-induced NF-kB-dependent gene transcription in the inflamed paw and spinal cord of rats.
Negative_regulation (inhibited) of Positive_regulation (induced) of NF-kB in nucleus associated with spinal cord
2) Confidence 0.57 Published 2001 Journal FASEB J. Section Abstract Doc Link 11099482 Disease Relevance 0.38 Pain Relevance 0.50
Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation.
Negative_regulation (blockade) of Positive_regulation (activation) of NF-kappaB associated with aspirin
3) Confidence 0.57 Published 1996 Journal Science Section Title Doc Link 8910280 Disease Relevance 0.18 Pain Relevance 0.53
Thus, similar concentrations of indomethacin both lowered the threshold thermal exposure to inhibit activation of NF-kappaB DNA-binding and increased the sensitivity of tumour cells to hyperthermic radiosensitization-induced cytotoxicity.
Negative_regulation (inhibit) of Positive_regulation (activation) of NF-kappaB
4) Confidence 0.55 Published 2002 Journal Int. J. Radiat. Biol. Section Body Doc Link 12065054 Disease Relevance 0 Pain Relevance 0
In accordance with the change of proinflammatory cytokines, Pentoxifylline (50 or 100mg/kg) significantly inhibited the activation of NF-kappaB in the brain.
Negative_regulation (inhibited) of Positive_regulation (activation) of NF-kappaB in brain associated with cytokine
5) Confidence 0.52 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17140731 Disease Relevance 0.44 Pain Relevance 0.68
Ketamine (5, 50 mg/kg) inhibited endotoxin-induced NF-kappa B activation.
Negative_regulation (inhibited) of Positive_regulation (activation) of NF-kappa B
6) Confidence 0.50 Published 2005 Journal Inflamm. Res. Section Body Doc Link 15883747 Disease Relevance 0.06 Pain Relevance 0
Dexamethasone decreased cytokine-induced NF-kappaB activation and iNOS mRNA expression, but neither salicylate nor aspirin affected NF-kappaB activation or iNOS mRNA expression.
Negative_regulation (decreased) of Positive_regulation (activation) of NF-kappaB associated with aspirin, dexamethasone and cytokine
7) Confidence 0.48 Published 1999 Journal Endocrinology Section Abstract Doc Link 10218970 Disease Relevance 0.42 Pain Relevance 0.66
Ketamine suppresses endotoxin-induced NF-kappaB activation and cytokines production in the intestine.
Negative_regulation (suppresses) of Positive_regulation (activation) of NF-kappaB in intestine associated with ketamine and cytokine
8) Confidence 0.47 Published 2004 Journal Acta Anaesthesiol Scand Section Title Doc Link 14982564 Disease Relevance 0.27 Pain Relevance 0.38
Ketamine 0.5 mg kg(-1) suppressed endotoxin-induced TNF-alpha elevation and inhibited NF-kappaB activation in the intestine; a dose of 5 mg kg(-1) was required to inhibit IL-6.
Negative_regulation (inhibited) of Positive_regulation (activation) of NF-kappaB in intestine
9) Confidence 0.47 Published 2004 Journal Acta Anaesthesiol Scand Section Body Doc Link 14982564 Disease Relevance 0 Pain Relevance 0
Ex vivo treatment with infliximab and etanercept decreased NF-kappaB activation in monocytes of patients with RA, but not in PBL and PBMC, and not in healthy subjects.
Neg (not) Negative_regulation (decreased) of Positive_regulation (activation) of NF-kappaB in monocytes
10) Confidence 0.43 Published 2007 Journal J. Rheumatol. Section Body Doc Link 17896809 Disease Relevance 0.12 Pain Relevance 0
Moreover, this compound reduces the increased NF-kappaB binding activity, which occurs in these degenerative conditions.
Negative_regulation (reduces) of Positive_regulation (increased) of NF-kappaB
11) Confidence 0.43 Published 2002 Journal Neurochem. Int. Section Abstract Doc Link 11918971 Disease Relevance 1.22 Pain Relevance 0.62
Acetaminophen protects hippocampal neurons and PC12 cultures from amyloid beta-peptides induced oxidative stress and reduces NF-kappaB activation.
Negative_regulation (reduces) of Positive_regulation (activation) of NF-kappaB in neurons associated with stress, paracetamol and alzheimer's dementia
12) Confidence 0.43 Published 2002 Journal Neurochem. Int. Section Title Doc Link 11918971 Disease Relevance 1.38 Pain Relevance 0.66
Moreover, activation of NF-kappaB by amyloid-derived peptides was greatly impaired by acetaminophen pre-treatment in hippocampal cells.
Negative_regulation (impaired) of Positive_regulation (activation) of NF-kappaB associated with paracetamol and alzheimer's dementia
13) Confidence 0.43 Published 2002 Journal Neurochem. Int. Section Abstract Doc Link 11918971 Disease Relevance 1.30 Pain Relevance 0.74
Pregabalin and gabapentin inhibit substance P-induced NF-kappaB activation in neuroblastoma and glioma cells.
Negative_regulation (inhibit) of Positive_regulation (activation) of NF-kappaB associated with pregabalin, neuroblastoma, gabapentin, glioma and substance p
14) Confidence 0.43 Published 2008 Journal J. Cell. Biochem. Section Title Doc Link 18615578 Disease Relevance 0.47 Pain Relevance 1.22
Pregabalin and gabapentin decreased substance P-induced NF-kappaB activation in these cells.
Negative_regulation (decreased) of Positive_regulation (activation) of NF-kappaB associated with pregabalin, gabapentin and substance p
15) Confidence 0.43 Published 2008 Journal J. Cell. Biochem. Section Abstract Doc Link 18615578 Disease Relevance 0.44 Pain Relevance 1.14
Flow cytometry assay revealed that tramadol attenuated the activation of NF-kappaB by 13.4%.
Negative_regulation (attenuated) of Positive_regulation (activation) of NF-kappaB
16) Confidence 0.43 Published 2009 Journal Eur J Anaesthesiol Section Body Doc Link 19829116 Disease Relevance 0 Pain Relevance 0
These results suggest that atorvastatin may be a novel and promising candidate for future treatment or prophylaxis of migraine via attenuating activation of NF-kappaB in trigeminal nucleus caudalis.
Negative_regulation (attenuating) of Positive_regulation (activation) of NF-kappaB in nucleus associated with migraine
17) Confidence 0.43 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19733216 Disease Relevance 0.39 Pain Relevance 0.32
Inhibition of NF kappa B activation by pyrrolidine dithiocarbamate prevents in vivo hypoxia/reoxygenation-mediated myocardial angiogenesis.
Negative_regulation (Inhibition) of Positive_regulation (activation) of NF kappa B associated with hypoxia
18) Confidence 0.43 Published 2000 Journal Int J Tissue React Section Title Doc Link 11199341 Disease Relevance 0.53 Pain Relevance 0.09
Here, we show that when restricted to spinal cord and targeted to glial cells, lentiviral vector-mediated delivery of NF-kappaB super- repressor IkappaBalpha resulted in an inhibition of the NF-kappaB pathway activated in the rat spinal cord after sciatic nerve injury (chronic constriction injury, CCI).
Negative_regulation (inhibition) of Positive_regulation (activated) of NF-kappaB in spinal cord associated with nervous system injury, eae, injury, sciatic nerve and spinal cord
19) Confidence 0.43 Published 2007 Journal Mol. Ther. Section Abstract Doc Link 17299402 Disease Relevance 0.95 Pain Relevance 1.15
Different criteria suggest that the observed effects are mediated at least in part through inhibition of NF-kB activation: R-flurbiprofen inhibited i) LPS-induced NF-kB DNA binding activity in RAW 264.7 macrophages, ii) translocation of the p65 subunit of NF-kB into the nucleus of these cells, and iii) zymosan-induced NF-kB-dependent gene transcription in the inflamed paw and spinal cord of rats.
Negative_regulation (inhibition) of Positive_regulation (activation) of NF-kB in nucleus associated with spinal cord
20) Confidence 0.42 Published 2001 Journal FASEB J. Section Abstract Doc Link 11099482 Disease Relevance 0.33 Pain Relevance 0.47

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox