INT65537

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Context Info
Confidence 0.67
First Reported 1995
Last Reported 2010
Negated 2
Speculated 4
Reported most in Abstract
Documents 52
Total Number 56
Disease Relevance 30.60
Pain Relevance 26.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nfkb1) DNA binding (Nfkb1) protein complex (Nfkb1)
cytoplasm (Nfkb1) cytosol (Nfkb1) signal transduction (Nfkb1)
Anatomy Link Frequency
intestine 6
stellate cells 4
spinal cord 4
TMJ 4
nucleus 4
Nfkb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 128 100.00 Very High Very High Very High
dorsal root ganglion 42 100.00 Very High Very High Very High
nMDA receptor 20 100.00 Very High Very High Very High
Spinal cord 20 100.00 Very High Very High Very High
allodynia 12 100.00 Very High Very High Very High
Nerve growth factor 8 100.00 Very High Very High Very High
Inflammatory stimuli 1 100.00 Very High Very High Very High
cytokine 63 99.98 Very High Very High Very High
substance P 8 99.98 Very High Very High Very High
Morphine 50 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 137 100.00 Very High Very High Very High
Ganglion Cysts 60 100.00 Very High Very High Very High
Neuropathic Pain 52 100.00 Very High Very High Very High
Cancer 33 100.00 Very High Very High Very High
Necrosis 18 100.00 Very High Very High Very High
Death 17 100.00 Very High Very High Very High
Stress 60 99.98 Very High Very High Very High
Pancreatitis 35 99.98 Very High Very High Very High
Periodontitis 30 99.98 Very High Very High Very High
Disease 22 99.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In rats pretreated with EcN, a significant downregulation of mRNA and protein expression for IL-1beta, COX-2 and PPARgamma and increased expression of HSP70 without major change in activation of NFkappaB were observed.
Positive_regulation (increased) of Positive_regulation (activation) of NFkappaB
1) Confidence 0.67 Published 2009 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 20224150 Disease Relevance 0.75 Pain Relevance 0.20
RESULTS: We demonstrated that intravenous administration of endotoxin could provoke significant lung injury, which was characterized by increase of MPO activity and wet/dry weight ratio, TNF-alpha and IL-6 expression and NF-kappa B activation.
Positive_regulation (increase) of Positive_regulation (activation) of NF-kappa B in lung
2) Confidence 0.59 Published 2005 Journal Inflamm. Res. Section Body Doc Link 15883747 Disease Relevance 0.07 Pain Relevance 0
Dexamethasone decreased cytokine-induced NF-kappaB activation and iNOS mRNA expression, but neither salicylate nor aspirin affected NF-kappaB activation or iNOS mRNA expression.
Positive_regulation (induced) of Positive_regulation (activation) of NF-kappaB associated with aspirin, dexamethasone and cytokine
3) Confidence 0.57 Published 1999 Journal Endocrinology Section Abstract Doc Link 10218970 Disease Relevance 0.42 Pain Relevance 0.66
RESULTS: Endotoxin caused transient production of TNF-alpha and IL-6 and activation of NF-kappaB in the intestine at peak times of 1, 4 and 1 h, respectively.
Positive_regulation (caused) of Positive_regulation (activation) of NF-kappaB in intestine
4) Confidence 0.56 Published 2004 Journal Acta Anaesthesiol Scand Section Body Doc Link 14982564 Disease Relevance 0 Pain Relevance 0
Excitotoxic spinal injury resulted in: (1) increased phosphorylation of ERK1/2; (2) increased activation of NF-kB and phosphorylation of ELK-1; and (3) increased gene expression for the NK-1 receptor and NR1 and NR-2A subunits of the NMDA receptor.
Positive_regulation (increased) of Positive_regulation (activation) of NF-kB in spinal associated with nmda receptor and spinal injuries
5) Confidence 0.52 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15922485 Disease Relevance 0.68 Pain Relevance 0.38
Nitroglycerin-induced NF-kappaB activation in trigeminal nucleus caudalis is believed to be partly involved in the pathogenesis of migraine.
Positive_regulation (induced) of Positive_regulation (activation) of NF-kappaB in nucleus associated with migraine
6) Confidence 0.50 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19733216 Disease Relevance 0.31 Pain Relevance 0.23
A significant increase of nuclear immunostaining of p65, an indicator of NF-kappaB activation, was detected in lamina I and II of nucleus trigeminalis caudalis in rats injected with NTG when compared with the control group.
Positive_regulation (increase) of Positive_regulation (activation) of NF-kappaB in nucleus
7) Confidence 0.48 Published 2005 Journal Neurotoxicology Section Abstract Doc Link 15936821 Disease Relevance 0.44 Pain Relevance 0.54
Pregabalin and gabapentin inhibit substance P-induced NF-kappaB activation in neuroblastoma and glioma cells.
Positive_regulation (induced) of Positive_regulation (activation) of NF-kappaB associated with pregabalin, neuroblastoma, gabapentin, glioma and substance p
8) Confidence 0.47 Published 2008 Journal J. Cell. Biochem. Section Title Doc Link 18615578 Disease Relevance 0.47 Pain Relevance 1.22
Pregabalin and gabapentin decreased substance P-induced NF-kappaB activation in these cells.
Positive_regulation (induced) of Positive_regulation (activation) of NF-kappaB associated with pregabalin, gabapentin and substance p
9) Confidence 0.47 Published 2008 Journal J. Cell. Biochem. Section Abstract Doc Link 18615578 Disease Relevance 0.44 Pain Relevance 1.14
These findings indicate that excess mechanical stress increases NF-kappaB activation in the TMJ and suggest that active NF-kappaB is involved in the progression of TMJ inflammation.
Positive_regulation (increases) of Positive_regulation (activation) of NF-kappaB in TMJ associated with stress, snapping jaw and inflammation
10) Confidence 0.47 Published 2003 Journal J. Dent. Res. Section Abstract Doc Link 12598546 Disease Relevance 0.89 Pain Relevance 0.45
The basis of our recently proposed "molecular inflammation theory of aging" is that activated inflammatory transcription factors, including versatile NF-kappaB, occur widespread in the organism during aging.
Positive_regulation (occur) of Positive_regulation (activated) of NF-kappaB associated with aging and inflammation
11) Confidence 0.46 Published 2006 Journal Mech. Ageing Dev. Section Abstract Doc Link 16310244 Disease Relevance 0.72 Pain Relevance 0.45
Chronic exposure to low doses of lead results in renal infiltration of immune cells, NF-kappaB activation, and overexpression of tubulointerstitial angiotensin II.
Positive_regulation (overexpression) of Positive_regulation (activation) of NF-kappaB in immune cells associated with inflammation
12) Confidence 0.45 Published 2005 Journal Antioxid. Redox Signal. Section Title Doc Link 16115032 Disease Relevance 0.33 Pain Relevance 0.19
Morphine and LPS treatment increased phosphorylation of the inhibitory protein kappaB, leading to an increased activity of NF-kappaB.
Positive_regulation (increased) of Positive_regulation (activity) of NF-kappaB associated with morphine
13) Confidence 0.45 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 16192499 Disease Relevance 0.12 Pain Relevance 1.79
AP-induced NF-kappaB activation was reduced by probiotics (0.20 vs. placebo 0.53 OD(450nm)/mg nuclear protein; P < 0.001).
Positive_regulation (induced) of Positive_regulation (activation) of NF-kappaB associated with pancreatitis
14) Confidence 0.45 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 18832452 Disease Relevance 1.56 Pain Relevance 0.19
To reveal NF-kappaB activation, we assessed inhibitory factor kappaBalpha (IkappaBalpha) mRNA expression by in situ hybridization, as NF-kappaB activation up-regulates IkappaBalpha gene expression as part of an autoregulatory feedback loop.
Positive_regulation (up-regulates) of Positive_regulation (activation) of NF-kappaB
15) Confidence 0.44 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16262636 Disease Relevance 0.94 Pain Relevance 1.30
Major carcinogens and oncogenic viruses induce NF-kappaB activation, and a variety of subsequent oncogenic events contribute to a progressive increase in constitutive NF-kappaB activation as an important common pathway in most forms of cancer.
Positive_regulation (induce) of Positive_regulation (activation) of NF-kappaB associated with cancer
16) Confidence 0.43 Published 2007 Journal Clin. Cancer Res. Section Abstract Doc Link 17317814 Disease Relevance 0.59 Pain Relevance 0.11
Ketamine 0.5 mg kg(-1) suppressed endotoxin-induced TNF-alpha elevation and inhibited NF-kappaB activation in the intestine; a dose of 5 mg kg(-1) was required to inhibit IL-6.
Positive_regulation (endotoxin-induced) of Positive_regulation (activation) of NF-kappaB in intestine
17) Confidence 0.41 Published 2004 Journal Acta Anaesthesiol Scand Section Body Doc Link 14982564 Disease Relevance 0 Pain Relevance 0
These observations suggest that intrathecal gp120 may lead to activation of NF-kappaB within the spinal cord.
Spec (may) Positive_regulation (lead) of Positive_regulation (activation) of NF-kappaB in spinal cord associated with spinal cord and intrathecal
18) Confidence 0.41 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16262636 Disease Relevance 1.04 Pain Relevance 1.28
Ketamine (5, 50 mg/kg) inhibited endotoxin-induced NF-kappa B activation.
Positive_regulation (induced) of Positive_regulation (activation) of NF-kappa B
19) Confidence 0.40 Published 2005 Journal Inflamm. Res. Section Body Doc Link 15883747 Disease Relevance 0.06 Pain Relevance 0
CONCLUSIONS: The fact that NF-kappaB is capable of transactivating pro-inflammatory mediators, which in turn can amplify NF-kappaB activation by a positive regulatory loop, suggests that inflammatory and/or immune responses in interstitial cystitis can be exacerbated possibly by persistent activation of this nuclear factor.
Positive_regulation (amplify) of Positive_regulation (activation) of NF-kappaB
20) Confidence 0.38 Published 1998 Journal J. Urol. Section Body Doc Link 9817309 Disease Relevance 0.06 Pain Relevance 0

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