INT65551

Context Info Confidence 0.69 First Reported 1995 Last Reported 2008 Negated 0 Speculated 1 Reported most in Abstract Documents 5 Total Number 6 Disease Relevance 1.52 Pain Relevance 3.74

plasma membrane (Htr3a) cytoplasm (Htr3a)

Anatomy Link Frequency aorta 1 infraorbital 1 Htr3a (Rattus norvegicus)

Pain Link Frequency Relevance Heat agonist 4 100.00 substance P 1 100.00 Pain 5 99.46 Pain threshold 2 99.44 Serotonin 7 98.32 nMDA receptor 1 97.96 antagonist 3 97.56 opioid receptor 1 96.68 Opioid 4 95.80 analgesia 7 95.48

Disease Link Frequency Relevance Heat Pain 7 99.46 Stress 5 96.08 Ganglion Cysts 6 93.32 Nervous System Injury 1 84.92 Injury 5 83.52 Functional Bowel Disorder 2 75.00 Neuropathic Pain 1 75.00 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super / Visceral Pain 1 65.96 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 3 54.88 Frailty 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

GeneChip analysis revealed that neither estrogen nor contraction alone changed the mRNA expression of substance P, the neurokinin-1 receptor, CGRP, NGF, the P2X3 receptor, GABAA and GABAB, the 5-HT3A and 5-HT3B receptor, N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors, opioid receptors, and opioid-like receptor.

Transcription (expression) of 5-HT3A associated with nmda receptor, opioid receptor, opioid and substance p

1) Confidence 0.69 Published 2006 Journal J. Appl. Physiol. Section Abstract Doc Link 16306253 Disease Relevance 0.29 Pain Relevance 0.83

Protein and mRNA expression levels of 5-HT3 receptors and 5-HT transporter were similar in MS and NH rats.

Transcription (expression) of 5-HT3

2) Confidence 0.69 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17110521 Disease Relevance 0.15 Pain Relevance 0.67

Ritanserin, a 5-HT2A/2C receptor antagonist, ondansetron, a 5-HT3 receptor antagonist and citalopram, a selective serotonin re-uptake blocker increased the baseline pain threshold, whereas 8-OH-DPAT, a full 5-HT1A receptor agonist and buspirone, a partial 5-HT1A receptor agonist expressing also high affinity towards dopaminergic D2 receptors, were without effect on pain perception and stress induced analgesia.

Transcription (expressing) of 5-HT1A receptor associated with stress, pain, pain threshold, antagonist, agonist, serotonin and analgesia

3) Confidence 0.56 Published 1995 Journal Pol J Pharmacol Section Abstract Doc Link 8868128 Disease Relevance 0.46 Pain Relevance 1.15

Thus, the 5-HT1B receptor mRNA detected in tissue extracts of the rat aorta most likely reflects 5-HT1B receptor expression in the arterioles of the vasa vasorum.

Transcription (detected) of 5-HT1B receptor in aorta

4) Confidence 0.52 Published 2002 Journal Recept. Channels Section Abstract Doc Link 12448788 Disease Relevance 0 Pain Relevance 0.46

Accordingly, we injured rats with an infraorbital nerve loose ligation and examined the pain thresholds, mRNA and mRNA editing of the 5HT2C receptor.

Spec (examined) Transcription (editing) of 5HT2C receptor in infraorbital associated with pain

5) Confidence 0.39 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18445227 Disease Relevance 0.50 Pain Relevance 0.55

Among the unique DE genes displayed in Table 1, a representative subset of seven genes were chosen for micorarray validation with real time reverse transcription PCR (real time RT-PCR); MN>dCIN: Nefl, Calcb, Kcna1, 5HT3r, VAChT; dCIN>MN: Ox2r, Viaat.

Transcription (transcription) of 5HT3r

6) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566599 Disease Relevance 0 Pain Relevance 0.08

General Comments

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