INT65554

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Context Info
Confidence 0.69
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 13
Total Number 18
Disease Relevance 8.16
Pain Relevance 5.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Hpse) extracellular region (Hpse) cell adhesion (Hpse)
proteinaceous extracellular matrix (Hpse) nucleus (Hpse) carbohydrate metabolic process (Hpse)
Anatomy Link Frequency
pituitary 3
lymph node 1
fat 1
immune cell 1
striatum 1
Hpse (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 10 99.84 Very High Very High Very High
cytokine 8 99.54 Very High Very High Very High
Opioid 41 99.30 Very High Very High Very High
cocaine 111 99.08 Very High Very High Very High
Inflammation 5 98.72 Very High Very High Very High
Morphine 103 98.08 Very High Very High Very High
antagonist 50 97.88 Very High Very High Very High
corticosteroid 4 96.88 Very High Very High Very High
cINOD 3 92.52 High High
Dopamine 33 92.16 High High
Disease Link Frequency Relevance Heat
Anxiety Disorder 24 99.90 Very High Very High Very High
Alopecia Areata 16 99.62 Very High Very High Very High
Stress 99 99.52 Very High Very High Very High
Autoimmune Disease 3 99.44 Very High Very High Very High
Cancer 9 98.96 Very High Very High Very High
INFLAMMATION 9 98.72 Very High Very High Very High
Metastasis 6 97.36 Very High Very High Very High
Wound Healing 9 97.24 Very High Very High Very High
Targeted Disruption 18 96.36 Very High Very High Very High
Necrosis 3 95.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we provide evidence that antibody 6F8 enhances the activity of recombinant and cellular heparanase, facilitates invasion of tumor-derived cells in vitro, and improves wound healing in a mouse punch model in vivo.
Positive_regulation (enhances) of heparanase associated with cancer and wound healing
1) Confidence 0.69 Published 2007 Journal FASEB J. Section Abstract Doc Link 17628014 Disease Relevance 0.82 Pain Relevance 0.13
Altogether, this transgenic mouse line shows an enhanced locomotor-stimulant effect to morphine, a response that is reflected by an enhanced DAergic activity within the mesolimbic system and is also associated with increased HPA activity.
Positive_regulation (increased) of HPA associated with targeted disruption and morphine
2) Confidence 0.55 Published 1996 Journal J. Neuroendocrinol. Section Abstract Doc Link 8868255 Disease Relevance 0.55 Pain Relevance 0.77
Clinically, up-regulation of heparanase mRNA and protein expression has been documented in a variety of primary human tumors, correlating with reduced postoperative survival and increased lymph node and distant metastasis, thus providing strong clinical support for the prometastatic feature of the enzyme and making it an attractive target for the development of anticancer and anti-inflammatory drugs.
Positive_regulation (up-regulation) of heparanase in lymph node associated with inflammation, cancer, cinod and metastasis
3) Confidence 0.50 Published 2007 Journal FASEB J. Section Abstract Doc Link 17628014 Disease Relevance 0.65 Pain Relevance 0.14
Screening a panel of monoclonal antibodies for their ability to inhibit heparanase enzymatic activity, we noted that one hybridoma, 6F8, exhibited the opposite effect and significantly enhanced heparanase activity.
Positive_regulation (enhanced) of heparanase
4) Confidence 0.50 Published 2007 Journal FASEB J. Section Abstract Doc Link 17628014 Disease Relevance 0.81 Pain Relevance 0.13
Using experimental rodent models, description of effects of heroin or cocaine, especially self administration of these drugs, on immune cell deficiency and HPA activation, was reviewed as well as effects on important proinflammatory cytokines like TNFalpha.
Positive_regulation (activation) of HPA in immune cell associated with cytokine and cocaine
5) Confidence 0.38 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 14741438 Disease Relevance 0.33 Pain Relevance 0.54
Just as a less variable HPA activation in response to conventional laboratory procedures mediates the reduced within-group variation, so also, from an evolutionary adaptive perspective, laboratory rodents should be adjusted to their specific adult conditions rather than to some sort of environmental challenge.
Positive_regulation (activation) of HPA
6) Confidence 0.30 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2000350 Disease Relevance 0.07 Pain Relevance 0.12
The positive correlation of HPA hormone levels with skin Th1 cytokines suggests that altered HPA activity may occur as a consequence of the immune response associated with AA.
Spec (may) Positive_regulation (occur) of HPA in skin associated with alopecia areata and cytokine
7) Confidence 0.26 Published 2009 Journal J. Invest. Dermatol. Section Abstract Doc Link 19020552 Disease Relevance 0.89 Pain Relevance 0.10
Both the motor responses and the HPA activation were diminished by the preadministration of the CRH antagonist, while haloperidol attenuated only square crossing and rearing.
Positive_regulation (activation) of HPA associated with antagonist
8) Confidence 0.24 Published 2003 Journal Horm Behav Section Abstract Doc Link 12694640 Disease Relevance 0 Pain Relevance 0.80
Since AP-1 is a potent repressor of GR activity [86], it seems that GR-mediated effects of HPA activation on gene transcription in the striatum after psychostimulant administration may have been inhibited by previous induction of the AP-1 complex proteins due to D1R activation.
Positive_regulation (activation) of HPA in striatum
9) Confidence 0.24 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.10 Pain Relevance 0.22
AA mice had a marked increase in hypothalamic-pituitary-adrenal (HPA) tone and activity centrally, and peripherally in the skin and lymph nodes.
Positive_regulation (increase) of HPA in pituitary associated with alopecia areata
10) Confidence 0.24 Published 2009 Journal J. Invest. Dermatol. Section Abstract Doc Link 19020552 Disease Relevance 1.11 Pain Relevance 0.10
Activation of the hypothalamic-pituitary-adrenal axis (HPA) and sympathetic nervous system by stress has been shown to modulate both innate and adaptive immunity during an experimental influenza A/PR8 viral infection.
Positive_regulation (Activation) of HPA in pituitary associated with stress, influenza virus infection and viral infection
11) Confidence 0.21 Published 2005 Journal Brain Behav. Immun. Section Abstract Doc Link 15664788 Disease Relevance 0.71 Pain Relevance 0.31
These results support a specific role for MORs in acute cocaine effects on striatal ppEnk gene expression and fail to support critical roles for these receptors in acute cocaine's effects on either ppDyn gene expression or HPA activation.
Positive_regulation (activation) of HPA associated with cocaine
12) Confidence 0.17 Published 2002 Journal Synapse Section Abstract Doc Link 12125043 Disease Relevance 0.07 Pain Relevance 0.80
However, this form of phenotypic induction seems to follow a U-shaped curve whereby stronger neonatal challenges, in the form of longer mother-offspring separations and highly demanding foraging conditions, induce a phenotype that resembles the control profile in behavioral fearfulness and HPA activation [5], [16], [17], [23].
Positive_regulation (activation) of HPA associated with anxiety disorder
13) Confidence 0.17 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2000350 Disease Relevance 0.25 Pain Relevance 0.04
Therefore, the present results suggested that ethanol- and/or opioid-induced activation of these genes depends on HPA and the release of steroid hormones from the adrenal gland.
Positive_regulation (depends) of HPA in adrenal gland associated with opioid
14) Confidence 0.17 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.07 Pain Relevance 0.38
Moreover, HPA activation is also a common effect of various drugs of abuse [74,75,85,89].
Positive_regulation (activation) of HPA
15) Confidence 0.17 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.40 Pain Relevance 0.16
One of the patterns is at least partially controlled by HPA activation.
Positive_regulation (activation) of HPA
16) Confidence 0.16 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0 Pain Relevance 0.07
This is in agreement with activation of the hypothalamic-pituitary-adrenal axis (HPA) after administration of opioids and ethanol [74,75].
Positive_regulation (activation) of HPA in pituitary associated with opioid
17) Confidence 0.14 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0 Pain Relevance 0.38
Furthermore, dietary fat intake acts as a background form of chronic stress, elevating basal corticosterone levels and enhancing HPA response to stress [43].
Positive_regulation (enhancing) of HPA in fat associated with stress
18) Confidence 0.11 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872226 Disease Relevance 1.32 Pain Relevance 0

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