INT6557

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Context Info
Confidence 0.77
First Reported 1985
Last Reported 2010
Negated 9
Speculated 5
Reported most in Abstract
Documents 65
Total Number 70
Disease Relevance 54.42
Pain Relevance 8.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Eno2) plasma membrane (Eno2) intracellular (Eno2)
cytoplasm (Eno2)
Anatomy Link Frequency
neuron 46
neuronal 4
neuroendocrine cells 2
macrophage 1
smooth muscle 1
Eno2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 43 100.00 Very High Very High Very High
Lamotrigine 90 99.92 Very High Very High Very High
Serotonin 9 98.92 Very High Very High Very High
Enkephalin 4 98.88 Very High Very High Very High
Pain 21 96.40 Very High Very High Very High
Somatostatin 9 96.00 Very High Very High Very High
ischemia 74 95.84 Very High Very High Very High
pain flank 3 95.48 Very High Very High Very High
Inflammation 24 93.88 High High
vincristine 1 91.60 High High
Disease Link Frequency Relevance Heat
Cancer 524 100.00 Very High Very High Very High
Adhesions 7 100.00 Very High Very High Very High
Carcinoid 88 99.98 Very High Very High Very High
Leiomyosarcoma 11 99.96 Very High Very High Very High
Multiple Myeloma 4 99.96 Very High Very High Very High
Carcinoma 29 99.88 Very High Very High Very High
Small Cell Lung Cancer 15 99.84 Very High Very High Very High
Neuroblastoma 7 99.78 Very High Very High Very High
Adenocarcinoma 26 99.24 Very High Very High Very High
Ductal Carcinoma 2 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neuron-specific enolase (NSE) is an isoform of the glycolytic enzyme, enolase, and is found in neurons and neuroendocrine cells.
Gene_expression (found) of Neuron-specific enolase in neuroendocrine cells
1) Confidence 0.77 Published 1993 Journal Brain Res. Section Abstract Doc Link 8221097 Disease Relevance 0.52 Pain Relevance 0.04
Neuron-specific enolase (NSE) is an isoform of the glycolytic enzyme, enolase, and is found in neurons and neuroendocrine cells.
Gene_expression (found) of NSE in neuroendocrine cells
2) Confidence 0.77 Published 1993 Journal Brain Res. Section Abstract Doc Link 8221097 Disease Relevance 0.52 Pain Relevance 0.04
Biopsy samples from eutopic endometrium were used for immunohistochemical staining to detect synaptophysin (SYN) and neuron-specific enolase (NSE) expression in women with and without endometriosis.
Gene_expression (expression) of neuron-specific enolase in neuron
3) Confidence 0.77 Published 2010 Journal Hum. Reprod. Section Body Doc Link 19910323 Disease Relevance 0 Pain Relevance 0
Immunohistochemical studies revealed that the tumour cells expressed neuron specific enolase and chromogranin.
Gene_expression (expressed) of neuron specific enolase in neuron associated with cancer
4) Confidence 0.76 Published 2009 Journal Orbit Section Abstract Doc Link 19839915 Disease Relevance 1.27 Pain Relevance 0.21
Immunohistochemical studies revealed that the tumour cells expressed neuron specific enolase and chromogranin.
Gene_expression (expressed) of neuron specific enolase in neuron associated with cancer
5) Confidence 0.76 Published 2009 Journal Orbit Section Abstract Doc Link 19874121 Disease Relevance 1.27 Pain Relevance 0.21
At birth, both NSE and cytochrome oxidase were expressed almost exclusively in the patches, appearing in the matrix only after the 2nd postnatal day.
Gene_expression (expressed) of NSE
6) Confidence 0.70 Published 1992 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 1330370 Disease Relevance 0 Pain Relevance 0.26
In addition, immunohistochemically, the cells stained for neuron-specific enolase, synaptophysin and chromogranin A.
Gene_expression (stained) of neuron-specific enolase in neuron
7) Confidence 0.66 Published 2000 Journal Intern. Med. Section Abstract Doc Link 11030210 Disease Relevance 0.97 Pain Relevance 0.08
The tumor cells of the small round cell carcinoma partly stained positively for synaptophysin, neuron-specific enolase, and CD 56, while adenocarcinoma cells showed positive reactions to keratin, which was thus suggestive of adenoendocrine cell carcinoma.
Gene_expression (stained) of neuron-specific enolase in neuron associated with adenocarcinoma, cancer, carcinoma and small cell lung cancer
8) Confidence 0.66 Published 2006 Journal Surg. Today Section Abstract Doc Link 16937295 Disease Relevance 0.90 Pain Relevance 0.09
Immunohistochemically, tumors cells were positive for chromogranin A, synaptophysin, and neuron-specific enolase.
Gene_expression (positive) of neuron-specific enolase in neuron associated with cancer
9) Confidence 0.66 Published 2001 Journal Breast Cancer Section Abstract Doc Link 11668250 Disease Relevance 0.99 Pain Relevance 0.08
The transplant was performed using collections that were negative or low in neuroblastoma cells (as detected by anti-neuron-specific enolase and antineuroblastoma monoclonal antibodies) after preparation with high-dose cyclophosphamide, etoposide, and cisplatin.
Gene_expression (detected) of anti-neuron-specific enolase in neuron associated with neuroblastoma
10) Confidence 0.65 Published 1989 Journal Transplantation Section Abstract Doc Link 2565052 Disease Relevance 0.36 Pain Relevance 0.08
The previous report has demonstrated a good relationship between the neurological outcome and serum NSE levels in the patients after cardiac arrest (Schoerkhuber et al 1990), suggesting that serum NSE levels can reflect the degrees of brain injury.
Gene_expression (levels) of NSE in brain associated with brain injury and myocardial infarction
11) Confidence 0.64 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721363 Disease Relevance 0.56 Pain Relevance 0.21
S-100beta protein and Neuron-Specific Enolase levels were not significantly different in anesthetized patients postoperatively compared with preoperative values.
Gene_expression (levels) of Neuron-Specific Enolase in Neuron
12) Confidence 0.59 Published 2005 Journal Can J Anaesth Section Body Doc Link 15684252 Disease Relevance 0 Pain Relevance 0
The plasma norepinephrine concentration was excessive and serum levels of neuron-specific enolase (NSE), calcitonin and parathormone were elevated.
Gene_expression (levels) of neuron-specific enolase in neuron
13) Confidence 0.58 Published 1994 Journal Hinyokika Kiyo Section Abstract Doc Link 7801842 Disease Relevance 1.11 Pain Relevance 0.13
The plasma norepinephrine concentration was excessive and serum levels of neuron-specific enolase (NSE), calcitonin and parathormone were elevated.
Gene_expression (levels) of NSE in neuron
14) Confidence 0.58 Published 1994 Journal Hinyokika Kiyo Section Abstract Doc Link 7801842 Disease Relevance 1.11 Pain Relevance 0.13
After the operation, norepinephrine and calcitonin decreased to normal but the levels of NSE and PTH remained high.
Gene_expression (levels) of NSE
15) Confidence 0.58 Published 1994 Journal Hinyokika Kiyo Section Abstract Doc Link 7801842 Disease Relevance 1.49 Pain Relevance 0.12
The effect of LTG on NSE level in serum and the number of NSE staining neurons
Gene_expression (level) of NSE in neurons associated with lamotrigine
16) Confidence 0.56 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721363 Disease Relevance 0.44 Pain Relevance 0.48
In order to determine the overall metabolic state of mesencephalic and striatal neurons during the period of up-regulation of TH gene expression, we have applied immunocytochemistry for neuron specific enolase (NSE), and cytochrome oxidase histochemistry, known markers for neuronal activity, as well as TH immunohistochemistry to the mesencephalon and striatum of postnatally developing rats.
Spec (determine) Gene_expression (expression) of neuron specific enolase in striatum
17) Confidence 0.54 Published 1992 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 1330370 Disease Relevance 0 Pain Relevance 0.33
A rare tumor in the adrenal region: neuron-specific enolase (NSE)-producing leiomyosarcoma in an elderly hypertensive patient.
Gene_expression (producing) of NSE in neuron associated with leiomyosarcoma, cancer and hypertension
18) Confidence 0.49 Published 2008 Journal Endocr. J. Section Title Doc Link 18250540 Disease Relevance 0.82 Pain Relevance 0.17
A rare tumor in the adrenal region: neuron-specific enolase (NSE)-producing leiomyosarcoma in an elderly hypertensive patient.
Gene_expression (producing) of neuron-specific enolase in neuron associated with leiomyosarcoma, cancer and hypertension
19) Confidence 0.49 Published 2008 Journal Endocr. J. Section Title Doc Link 18250540 Disease Relevance 0.82 Pain Relevance 0.17
Notably, NSE protein was massively expressed in the resected tumor.
Gene_expression (expressed) of NSE associated with cancer
20) Confidence 0.49 Published 2008 Journal Endocr. J. Section Abstract Doc Link 18250540 Disease Relevance 0.87 Pain Relevance 0.14

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