INT65573

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Context Info
Confidence 0.11
First Reported 1995
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.08
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grid1)
Grid1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 3 100.00 Very High Very High Very High
Morphine 5 99.70 Very High Very High Very High
Ventral tegmentum 5 97.28 Very High Very High Very High
GABA receptor 1 96.48 Very High Very High Very High
Glutamate 3 95.76 Very High Very High Very High
opiate 5 89.28 High High
Nicotine 1 87.52 High High
Dopamine 4 78.92 Quite High
addiction 2 77.04 Quite High
Substantia nigra 1 76.52 Quite High
Disease Link Frequency Relevance Heat
Opiate Addiction 2 77.04 Quite High
Alcohol Addiction 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that repeated administration of morphine significantly elevated aAbs levels to MDOR and to the AMPA GluR1 subunit, but not to the NMDA NR2 subunit.
Neg (not) Positive_regulation (elevated) of AMPA GluR1 subunit associated with morphine
1) Confidence 0.11 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16687214 Disease Relevance 0.08 Pain Relevance 0.65
It was found that long-term, but not short-term, ethanol exposure increased levels of immunoreactivity of the NMDAR1 subunit, an obligatory component of NMDA glutamate receptors, and of the GluR1 subunit, a component of many AMPA glutamate receptors; but at the same time, long-term ethanol exposure decreased immunoreactivity levels of the alpha 1 subunit of the GABAA receptor complex.
Positive_regulation (increased) of GluR1 subunit associated with glutamate receptor
2) Confidence 0.00 Published 1995 Journal Synapse Section Abstract Doc Link 8869159 Disease Relevance 0 Pain Relevance 0.76

General Comments

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