INT65576

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Context Info
Confidence 0.45
First Reported 1995
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.25
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GFAP) extracellular matrix organization (GFAP) cytoplasm (GFAP)
Anatomy Link Frequency
LGN 2
GFAP (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 3 98.86 Very High Very High Very High
Morphine 3 98.62 Very High Very High Very High
Ventral tegmentum 5 97.08 Very High Very High Very High
Dopamine 4 84.84 Quite High
Nucleus accumbens 3 84.80 Quite High
Substantia nigra 1 76.00 Quite High
Central nervous system 22 71.24 Quite High
Glutamate 3 47.52 Quite Low
GABA receptor 1 35.84 Quite Low
Glutamate receptor 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Optic Nerve Injuries 35 97.20 Very High Very High Very High
Ocular Hypertension 71 96.52 Very High Very High Very High
Glaucoma 9 5.00 Very Low Very Low Very Low
Ganglion Cysts 8 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low
Frailty 4 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, as seen for chronic morphine and cocaine treatments, we show here that chronic ethanol treatment increased levels of tyrosine hydroxylase and glial fibrillary acidic protein immunoreactivity, and decreases levels of neurofilament protein immunoreactivity, in the VTA.
Positive_regulation (increased) of Regulation (immunoreactivity) of glial fibrillary acidic protein associated with ventral tegmentum, cocaine and morphine
1) Confidence 0.45 Published 1995 Journal Synapse Section Abstract Doc Link 8869159 Disease Relevance 0 Pain Relevance 0.81
GFAP and MAC-1 immunoreactivities were elevated in spatial register with the treated eye layers of the LGN and V1 in ONT animals.
Positive_regulation (elevated) of Regulation (immunoreactivities) of GFAP in LGN associated with optic nerve injuries
2) Confidence 0.38 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2773743 Disease Relevance 1.25 Pain Relevance 0.10

General Comments

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